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28-08-2020

The association between self-reported health status and adverse events: a comparison among coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI)

Auteurs: Stine Nørris Nielsen, Trine Bernholdt Rasmussen, Jens Flensted Lassen, Selina Kikkenborg Berg, Lars Thrysoee, Jacob Eifer Møller, Lisette Okkels Jensen, Anne Langhoff Thuesen, Anne Vinggaard Christensen, Ola Ekholm, Rikke Mols, Charlotte Brun Thorup, Britt Borregaard

Gepubliceerd in: Quality of Life Research | Uitgave 11/2020

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Abstract

Purpose

While several studies have investigated clinical outcomes following coronary artery bypass grafting (CABG) vs. percutaneous coronary intervention (PCI), studies investigating self-reported health and the association with adverse outcomes are limited. Thus, the aim was to investigate differences in health-related quality of life (HRQoL), anxiety and depression at discharge and the association with a composite endpoint of the first event of acute cardiac readmission, revascularisation or 1-year mortality among patients undergoing CABG vs. PCI.

Methods

Data from the national cohort study, DenHeart, were used, including measures of HRQoL; EuroQoL-5D-5L (EQ-5D Index Score and VAS) and HeartQoL (Global, Physical and Emotional), anxiety and depression (Hospital Anxiety and Depression Scale, HADS) and register-based follow-up. A total of 7000 patients were included (CABG n = 652, PCI n = 6348) (median age 65, 75% men). Cox Proportional Hazard models were performed among a propensity-matched population of responders (n = 520).

Results

HRQoL was significantly better among patients undergoing PCI vs. CABG, but with no differences in time to readmission or revascularisation. HRQoL, anxiety and depression were significantly associated with the risk of the composite endpoint among the PCI group (Hazard Ratio, HR (95% confidence intervals, CI) [EQ-5D index score 3.07 (1.67–5.67), EQ-5D VAS 0.97 (0.96–0.99), HeartQol Global 0.61 (0.38–0.95), HeartQol Emotional 0.56 (0.39–0.80), HADS-D ≥ 8 3.12 (1.61–6.01), HADS-A ≥ 8 2.08 (1.14–3.80)].

Conclusion

Patients undergoing PCI reported better HRQoL at discharge compared with patients undergoing CABG, whereas readmission rates were similar. Self-reported health was associated with the risk of adverse events among patients undergoing PCI, but not among patients undergoing CABG.

Clinical trial registration

NCT01926145.
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Titel
The association between self-reported health status and adverse events: a comparison among coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI)
Auteurs
Stine Nørris Nielsen
Trine Bernholdt Rasmussen
Jens Flensted Lassen
Selina Kikkenborg Berg
Lars Thrysoee
Jacob Eifer Møller
Lisette Okkels Jensen
Anne Langhoff Thuesen
Anne Vinggaard Christensen
Ola Ekholm
Rikke Mols
Charlotte Brun Thorup
Britt Borregaard
Publicatiedatum
28-08-2020
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 11/2020
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-020-02573-8