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Journal of Autism and Developmental Disorders

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03-06-2015 | Original Paper

The Association Between Autism Spectrum Disorders and Congenital Anomalies by Organ Systems in a Finnish National Birth Cohort

Auteurs: Laura Timonen-Soivio, Andre Sourander, Heli Malm, Susanna Hinkka-Yli-Salomäki, Mika Gissler, Alan Brown, Raija Vanhala

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2015

Abstract

The aim of this study was to evaluate the association between autism spectrum disorders (ASD) with and without intellectual disability (ID) and congenital anomalies (CAs) by organ system. The sample included all children diagnosed with ASD (n = 4441) from the Finnish Hospital Discharge Register during 1987–2000 and a total of four controls per case (n = 17,695). CAs of the eye, central nervous system, and specific craniofacial anomalies were most strongly associated with ASD. Children with ASD and co-occurring ID were more likely to have CAs compared to ASD children without ID. The results suggest that some cases of ASD may originate during organogenesis, in the early first trimester of pregnancy. The results of this study may be useful for identifying prenatal etiological factors and elucidating the molecular pathogenesis of ASD.

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Titel: The Association Between Autism Spectrum Disorders and Congenital Anomalies by Organ Systems in a Finnish National Birth Cohort
Auteurs: Laura Timonen-Soivio
Andre Sourander
Heli Malm
Susanna Hinkka-Yli-Salomäki
Mika Gissler
Alan Brown
Raija Vanhala
Publicatiedatum: 03-06-2015
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 10/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-015-2477-7

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