Swipe om te navigeren naar een ander artikel
The online version of this article (doi:10.1007/s11136-015-0995-6) contains supplementary material, which is available to authorized users.
To examine the effect of comorbidities on health-related quality of life (HRQoL) and their interaction with asthma control.
In a random sample of adults with asthma, we measured generic (EQ5D) and disease-specific (AQ5D) utility scores. Asthma symptom control was determined using the 2014 Global Initiative for Asthma Management Strategy. Comorbidity scores were calculated using a validated questionnaire. We used two-part regression models to measure the adjusted difference in utility across levels of symptom control and comorbidity scores and to examine the relative role of symptom control and comorbidity in explaining the variation in HRQoL.
A total of 2,299 observations from 460 adult patients (mean age 52 years, 67 % women) were included. Compared to controlled asthma, uncontrolled asthma was associated with −0.018 reduction (95 % CI −0.028, −0.009) in EQ5D and −0.076 reduction (95 % CI −0.115, −0.052) in AQ5D utilities. An increase by one standard deviation in comorbidity score relative to the mean was associated with a change of −0.029 (95 % CI −0.043, −0.016) in EQ5D and −0.010 (95 % CI −0.020, −0.004) in AQLQ utilities. The impact of comorbidity was greater than asthma symptom control in explaining EQ5D variance (12 vs. 1 %) but smaller in explaining AQ5D variance (3 vs. 12 %).
Generic and disease-specific HRQoL instruments differentially capture the impact of symptom control and comorbidity in asthma. The selection of HRQoL instruments for asthma studies should depend on the prevalence of comorbidity in the target population and the impact of interventions on asthma control and comorbidity.
Log in om toegang te krijgen
Met onderstaand(e) abonnement(en) heeft u direct toegang:
Supplementary material 1 (PDF 101 kb)11136_2015_995_MOESM1_ESM.pdf
Reddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L.-P., Boushey, H. A., Busse, W. W., et al. (2009). An official American Thoracic Society/European Respiratory Society statement: Asthma control and exacerbations: Standardizing endpoints for clinical asthma trials and clinical practice. American Journal of Respiratory and Critical Care Medicine, 180(1), 59–99. CrossRefPubMed
Braido, F., Baiardini, I., Balestracci, S., Fassio, O., Ravera, S., Bellotti, M., et al. (2008). The relationship between asthma control and quality-of-life impairment due to chronic cough: A real-life study. Annals of Allergy, Asthma & Immunology, 101(4), 370–374. CrossRef
Pérez De Llano, L. A., González, F. C., Añón, O. C., Perea, M. P., Caruncho, M. V., Villar, A. B., et al. (2010). [Relationship between comorbidity and asthma control]. [Article in Spanish]. Archivos de Bronconeumología, 46(10), 508–513.
GINA Report. (2014). Global strategy for asthma management and prevention. http://www.ginasthma.org/documents/4. Accessed 4 July 2014.
Open Data from the Census—BC Stats. (2014). http://www.bcstats.gov.bc.ca/StatisticsBySubject/Census/OpenData.aspx. Accessed 4 July 2014.
Zeger, S., Liang, K., & Albert, P. (1989). Models for longitudinal data: A generalized estimating equation approach. Biometrics, 1989(1), 347.
Frank, K. A. (2000). Impact of a confounding variable on a regression coefficient. Sociological Methods & Research, 29(2), 147–194. CrossRef
- The added effect of comorbidity on health-related quality of life in patients with asthma
Larry D. Lynd
J. Mark FitzGerald
Carlo A. Marra
- Springer International Publishing