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Gepubliceerd in: Journal of Autism and Developmental Disorders 5/2019

03-01-2019 | Original Article

Temperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants

Auteurs: M. K. J. Pijl, G. Bussu, T. Charman, M. H. Johnson, E. J. H. Jones, G. Pasco, I. J. Oosterling, N. N. J. Rommelse, J. K. Buitelaar, The BASIS Team

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2019

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Abstract

To investigate temperament as an early risk marker for autism spectrum disorder (ASD), we examined parent-reported temperament for high-risk (HR, n = 170) and low-risk (LR, n = 77) siblings at 8, 14, and 24 months. Diagnostic assessment was performed at 36 months. Group-based analyses showed linear risk gradients, with more atypical temperament for HR-ASD, followed by HR-Atypical, HR-Typical, and LR siblings. Temperament differed significantly between outcome groups (0.03 ≤ ηp2 ≤ 0.34). Machine learning analyses showed that, at an individual level, HR-ASD siblings could not be identified accurately, whereas HR infants without ASD could. Our results emphasize the discrepancy between group-based and individual-based predictions and suggest that while temperament does not facilitate early identification of ASD individually, it may help identify HR infants who do not develop ASD.
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Metagegevens
Titel
Temperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants
Auteurs
M. K. J. Pijl
G. Bussu
T. Charman
M. H. Johnson
E. J. H. Jones
G. Pasco
I. J. Oosterling
N. N. J. Rommelse
J. K. Buitelaar
The BASIS Team
Publicatiedatum
03-01-2019
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-018-3855-8