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Schizophrenia and intellectual disability (ID) co-occur three times more than would be expected by chance. This has led to speculation that a particular form of schizophrenia may give rise to both the symptoms of schizophrenia and the intellectual impairment. If this was the case, one may expect the presentation of schizophrenia in an ID population to differ from that in a population with average/high IQ. A systematic review and meta-analysis was undertaken of studies comparing the clinical presentation of schizophrenia in people with mild/borderline ID to that in people with average/high IQ. Five studies were eligible for inclusion. Four reported more negative symptoms in the ID population, while two reported more positive symptoms. Meta-analysis demonstrated that the ID population experienced more negative symptoms. The available evidence supports the proposal that the clinical presentation of schizophrenia in an ID population differs from that in a population with normal IQ.
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American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.
Andreasen, N. C. (1989). The scale for the assessment of negative symptoms (SANS): Conceptual and theoretical foundations. The British Journal of Psychiatry.Supplement, (7)(7), 49–58.
Asberg, M., Montgomery, S. A., Perris, C., Schalling, D., & Sedvall, G. (1978). A comprehensive psychopathological rating scale. Acta Psychiatrica Scandinavica, 58(S271), 5–27. CrossRef
Bradburn, M. J., Deeks, J. J., & Altman, D. G. (1999). Metan-an alternative meta-analysis command. Stata Technical Bulletin, 8(44).
Cooper, H. E., & Hedges, L. V. (1994). The handbook of research synthesis.
Endicott, J., & Spitzer, R. L. (1978). A diagnostic interview: the schedule for affective disorders and schizophrenia. Archives of General Psychiatry, 35(7), 837–844. PubMed
Glick, M., & Zigler, E. (1995). Developmental differences in the symptomatology of psychiatric inpatients with and without mild mental retardation. American Journal of Mental Retardation, 99(4), 407–417. PubMed
Hassiotis, A., Ukoumunne, O., Tyrer, P., Piachaud, J., Gilvarry, C., Harvey, K., et al. (1999). Prevalence and characteristics of patients with severe mental illness and borderline intellectual functioning. report from the UK700 randomised controlled trial of case management. The British Journal of Psychiatry, 175(2), 135–140. PubMedCrossRef
Hassiotis, A., Strydom, A., Hall, I., Ali, A., Lawrence-Smith, G., Meltzer, H., et al. (2008). Psychiatric morbidity and social functioning among adults with borderline intelligence living in private households. Journal of Intellectual Disability Research, 52(2), 95–106. PubMed
Hatton, C., Haddock, G., Taylor, J. L., Coldwell, J., Crossley, R., & Peckham, N. (2005). The reliability and validity of general psychotic rating scales with people with mild and moderate intellectual disabilities: an empirical investigation. Journal of Intellectual Disability Research, 49(7), 490–500. PubMedCrossRef
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13(2), 261–276. PubMed
Kraepelin, E. (1919). Dementia praecox and paraphrenia. Edinburgh: Livingstone.
Muir, W. J., Davidson, C., & Doody, G. A. (1998). A complex re-arrangement of karyotype involving chromosomes 2 and 11 detected in a patient with the dual diagnosis of schizophrenia and mild learning disability. American Journal of Medical Genetics (Neuropsychiatric Genetics), 81, 552–553.
Nelson, H. E. (1982). National adult reading test (NART): Test manual. Windsor: NFER Nelson.
Rosenberg, M. S., Adams, D. C., & Gurevitch, J. (2000). MetaWin: Statistical software for meta-analysis: Version 2.0. Sunderland: Sinauer Associates.
Schultze-Lutter, F., & Klosterkötter, J. (1995). Do basic symptoms provide a possible explanation for the elevated risk for schizophrenia among mentally retarded. Neurology Psychiatry and Brain Research, 3, 29–34.
Wechsler, D. (1981). WAIS-R manual: Wechsler adult intelligence scale-revised. New York: Psychological Corp.
- Systematic Review of the Clinical Presentation of Schizophrenia in Intellectual Disability
Killian A. Welch
Stephen M. Lawrie
Eve C. Johnstone
- Springer US
Journal of Psychopathology and Behavioral Assessment
Print ISSN: 0882-2689
Elektronisch ISSN: 1573-3505