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09-02-2018 | Review | Uitgave 8/2018

Quality of Life Research 8/2018

Systematic review of quality of life in Turner syndrome

Quality of Life Research > Uitgave 8/2018
Carolina Trombeta Reis, Maíra Seabra de Assumpção, Gil Guerra-Junior, Sofia Helena Valente de Lemos-Marini



This study aimed to systematically review the available literature on “quality of life” (QoL) or “health-related quality of life” (HRQoL) in Turner syndrome (TS) patients and to analyze the relations among height, puberty, and the use of growth hormone (GH) and the QoL of TS patients.


An electronic bibliographic search was conducted through the PubMed, Embase, Bireme, Scopus, and Web of Science databases. The main terms were “Quality of Life” and “Turner syndrome.”


Among the databases, 559 articles were found; after the selection process, 13 studies were selected. A quality assessment was conducted, and all the studies were of high quality. Eight well-known QoL questionnaires were used, and the selected studies presented factors that may be related to the QoL of TS patients, such as height, puberty, and GH use. However, a more detailed understanding of which factors are associated with the QoL of TS patients is still needed, which may be due to the lack of specific QoL instruments involving important aspects related to TS.


The QoL of TS patients appears to be compromised, but existing data regarding the relations among height, puberty, and GH and QoL are still controversial. Although these factors should be carefully considered in TS patients, it was not possible to determine whether they have a significant relation with the QoL of TS patients.

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