Top

Optie A:

Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
Optie B:

Deel de link per e-mail
Link delen

volgende artikel Interpretation of Logical Words in Mandarin-Spe...

Tip

Swipe om te navigeren naar een ander artikel

01-07-2015 | Original Paper | Uitgave 7/2015

Symptoms of Autism in Males with Fragile X Syndrome: A Comparison to Nonsyndromic ASD Using Current ADI-R Scores

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 7/2015

Auteurs:: Andrea McDuffie, Angela John Thurman, Randi J. Hagerman, Leonard Abbeduto

» Toegang tot de volledige tekst krijgen

Abstract

Symptoms of autism are frequent in males with fragile X syndrome (FXS), but it is not clear whether symptom profiles differ from those of nonsyndromic ASD. Using individual item scores from the Autism Diagnostic Inventory-Revised, we examined which current symptoms of autism differed in boys with FXS relative to same-aged boys diagnosed with nonsyndromic ASD. In addition, different subsamples of participants were matched on autism diagnostic status and severity of autism symptoms. Between-group comparisons revealed that boys with FXS showed significantly less impairment in Social Smiling than did age-, diagnostic-, and severity-matched boys with nonsyndromic ASD. Severity-matched boys with FXS showed more impairment in complex mannerisms than did boys with nonsyndromic ASD. Behavioral differences between FXS and nonsyndromic ASD may be of theoretical importance in understanding the causes and correlates of ASD in FXS and in developing and implementing appropriate treatments.

Log in om toegang te krijgen

Hier inloggen

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Psychologie Totaal

Met BSL Psychologie Totaal blijft u als professional steeds op de hoogte van de nieuwste ontwikkelingen binnen uw vak. Met het online abonnement heeft u toegang tot een groot aantal boeken, protocollen, vaktijdschriften en e-learnings op het gebied van psychologie en psychiatrie. Zo kunt u op uw gemak en wanneer het u het beste uitkomt verdiepen in uw vakgebied.

Meer informatie

Abbeduto, L., Brady, N., & Kover, S. T. (2007). Language development and fragile X syndrome: Profiles, syndrome-specificity, and within-syndrome differences. Mental Retardation And Developmental Disabilities Research Reviews, 13(1), 36–46.

Bailey, D. B., Hatton, D. D., Mesibov, G., Ament, N., & Skinner, M. (2000). Early development, temperament, and functional impairment in autism and fragile X syndrome. Journal of Autism and Developmental Disorders, 30(1), 49–59. PubMedCrossRef

Bailey, D. B., Mesibov, G. B., Hatton, D. D., Clark, R. D., Roberts, J. E., & Mayhew, L. (1998). Autistic behavior in young boys with fragile X syndrome. Journal of Autism and Developmental Disorders, 28(6), 499–508. PubMedCrossRef

Bailey, D. B., Sideris, J., Roberts, J., & Hatton, D. (2008). Child and genetic variables associated with maternal adaptation to fragile X syndrome: A multidimensional analysis. American Journal of Medical Genetics Part A, 146(6), 720–729. CrossRef

Belmonte, M. K., & Bourgeron, T. (2006). Fragile X syndrome and autism at the intersection of genetic and neural networks. Nature Neuroscience, 9(10), 1221–1225. PubMedCrossRef

Berry-Kravis, E., Hessl, D., Abbeduto, L., Reiss, A. L., Beckel-Mitchener, A., & Urv, T. K. (2013). Outcome measures for clinical trials in fragile X syndrome. Journal of Developmental and Behavioral Pediatrics, 34(7), 508–522.

Berry-Kravis, E. M., Hessl, D., Rathmell, B., Zarevics, P., Cherubini, M., Walton-Bowen, K., et al. (2012). Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: A randomized, controlled, phase 2 trial. Science Translational Medicine, 4(152), 1–7. CrossRef

Bhakar, A. L., Dölen, G., & Bear, M. F. (2012). The pathophysiology of fragile X (and what it teaches us about synapses). Annual Review of Neuroscience, 35, 417–443. PubMedCentralPubMedCrossRef

Bishop, S. L., Hus, V., Duncan, A., Huerta, M., Gotham, K., Pickles, A., et al. (2013). Subcategories of restricted and repetitive behaviors in children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(6), 1287–1297.

Bishop, S. L., Richler, J., & Lord, C. (2006). Association between restricted and repetitive behaviors and nonverbal IQ in children with autism spectrum disorders. Child Neuropsychology, 12(4–5), 247–267.

Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000). Varieties of repetitive behavior in autism: Comparisons to mental retardation. Journal of Autism and Developmental Disorders, 30(3), 237–243. PubMedCrossRef

Brock, M., & Hatton, D. (2010). Distinguishing features of autism in boys with fragile X syndrome. Journal of Intellectual Disability Research, 54(10), 894–905. PubMedCrossRef

Caglayan, A. (2010). Genetic causes of syndromic and non-syndromic autism. Developmental Medicine and Child Neurology, 52, 130–138. PubMedCrossRef

Clifford, S., Dissanayake, C., Bui, Q. M., Huggins, R., Taylor, A. K., & Loesch, D. Z. (2007). Autism spectrum phenotype in males and females with fragile X full mutation and premutation. Journal of Autism and Developmental Disorders, 37(4), 738–747. PubMedCrossRef

Cordeiro, L., Ballinger, E., Hagerman, R., & Hessl, D. (2011). Clinical assessment of DSM-IV anxiety disorders in fragile X syndrome: Prevalence and characterization. Journal of Neurodevelopmental disorders, 3(1), 57–67. PubMedCentralPubMedCrossRef

Cornish, K., Scerif, G., & Karmiloff-Smith, A. (2007). Tracing syndrome-specific trajectories of attention across the lifespan. Cortex, 43(6), 672–685. PubMedCrossRef

Dalton, K. M., Holsen, L., Abbeduto, L., & Davidson, R. J. (2008). Brain function and gaze fixation during facial-emotion processing in fragile X and autism. Autism Research, 1(4), 231–239. PubMedCentralPubMedCrossRef

Demark, J. L., Feldman, M. A., & Holden, J. J. (2003). Behavioral relationship between autism and fragile X syndrome. American Journal on Mental Retardation, 108(5), 314–326. PubMedCrossRef

Dissanayake, C., Bui, Q., Bulhak-Paterson, D., Huggins, R., & Loesch, D. Z. (2009). Behavioural and cognitive phenotypes in idiopathic autism versus autism associated with fragile X syndrome. Journal of Child Psychology and Psychiatry, 50(3), 290–299. PubMedCrossRef

Feinstein, C., & Reiss, A. L. (1998). Autism: The point of view from fragile X studies. Journal of Autism and Developmental Disorders, 28(5), 393–405. PubMedCrossRef

Gallagher, A., & Hallahan, B. (2012). Fragile X-associated disorders: A clinical overview. Journal of Neurology, 259(3), 401–413. PubMedCrossRef

Gotham, K., Bishop, S. L., Hus, V., Huerta, M., Lund, S., Buja, A., et al. (2013). Exploring the relationship between anxiety and insistence on sameness in autism spectrum disorders. Autism Research, 6, 33–41. PubMedCentralPubMedCrossRef

Gotham, K., Pickles, A., & Lord, C. (2009). Standardizing ADOS scores for a measure of severity in autism spectrum disorders. Journal of Autism and Developmental Disorders, 39(5), 693–705. PubMedCentralPubMedCrossRef

Hagerman, R. J. (1999). Neurodevelopmental disorders: Diagnosis and treatment (pp. 61–132). New York: Oxford University Press.

Hagerman, R. J. (2002). Physical and behavioral phenotypes. In R. Hagerman & P. Hagerman (Eds.), Fragile X syndrome: Diagnosis, treatment, and research (pp. 206–248). Baltimore, MD: Johns Hopkins University Press.

Hagerman, R., Lauterborn, J., Au, J., & Berry-Kravis, E. (2012). Fragile X syndrome and targeted treatment trials. In R. Denman (Ed.), Modeling fragile X syndrome (pp. 297–335). Berlin: Springer. CrossRef

Hall, S. S., Lightbody, A. A., Hirt, M., Rezvani, A., & Reiss, A. L. (2010). Autism in fragile X syndrome: A category mistake? Journal of the American Academy of Child and Adolescent Psychiatry, 49(9), 921–933. PubMedCentralPubMedCrossRef

Harris, S. W., Hessl, D., Goodlin-Jones, B., Ferranti, J., Bacalman, S., Barbato, I., et al. (2008). Autism profiles of males with fragile X syndrome. American Journal on Mental Retardation, 113(6), 427–438. PubMedCentralPubMedCrossRef

Hernandez, R. N., Feinberg, R. L., Vaurio, R., Passanante, N. M., Thompson, R. E., & Kaufmann, W. E. (2009). Autism spectrum disorder in fragile X syndrome: A longitudinal evaluation. American Journal of Medical Genetics, 149(6), 1125–1137. CrossRef

Hessl, D., Dyer-Friedman, J., Glaser, B., Wisbeck, J., Barajas, R. G., Taylor, A., et al. (2001). The influence of environmental and genetic factors on behavior problems and autistic symptoms in boys and girls with fragile X syndrome. Pediatrics, 108(5), e88. PubMedCrossRef

Hessl, D., Nguyen, D., Green, C., Chavez, A., Tassone, F., Hagerman, R., et al. (2009). A solution to limitations of cognitive testing in children with intellectual disabilities: The case of fragile X syndrome. Journal of Neurodevelopmental Disorders, 1(1), 33–45. PubMedCentralPubMedCrossRef

Hoeft, F., Walter, E., Lightbody, A. A., Hazlett, H. C., Chang, C., Piven, J., et al. (2010). Neuroanatomical differences in toddler boys with fragile X syndrome and idiopathic autism. Archives of General Psychiatry, 3, 295–305.

Hus, V., Gotham, K., & Lord, C. (2013). Standardizing ADOS domain scores: Separating severity of social affect and restricted and repetitive behaviors. Journal of Autism and Developmental Disorders. doi: 10.1007/s10803-012-1719-1.

Kau, A. S. M., Tierney, E., Bukelis, I., Stump, M. H., Kates, W. R., Trescher, W. H., & Kaufmann, W. E. (2004). Social behavior profile in young males with fragile X syndrome: Characteristics and specificity. American Journal of Medical Genetics Part A, 126(1), 9–17.

Kaufmann, W., Cortell, R., Kau, A., Bukelis, I., Tierney, E., Gray, R., et al. (2004). Autism spectrum disorder in fragile X syndrome: Communication, social interaction, and specific behaviors. American Journal of Medical Genetics Part A, 129(3), 225–234. CrossRef

Kaufmann, W. E., & Reiss, A. L. (1999). Molecular and cellular genetics of fragile X syndrome. American Journal of Medical Genetics, 88(1), 11–24. PubMedCrossRef

Kim, S. H., & Lord, C. (2012). New autism diagnostic interview-revised algorithms for toddlers and young preschoolers from 12 to 47 months of age. Journal of Autism and Developmental Disorders, 42(1), 82–93. PubMedCrossRef

Loesch, D. Z., Bui, Q. M., Dissanayake, C., Clifford, S., Gould, E., Bulhak-Paterson, D., et al. (2007). Molecular and cognitive predictors of the continuum of autistic behaviours in fragile X. Neuroscience and Biobehavioral Reviews, 31(3), 315–326. PubMedCentralPubMedCrossRef

Lord, C., Petkova, E., Hus, V., Gan, W., Lu, F., Martin, D. M., et al. (2012). A multisite study of the clinical diagnosis of different autism spectrum disorders. Archives of General Psychiatry, 63, 306–313. CrossRef

Lord, C., Rutter, M., DiLavore, P., & Risi, S. (2007). Autism diagnostic observation schedule. Los Angeles, CA: Western Psychological Services.

Martin, G. E., Roberts, J. E., Helm-Estabrooks, N., Sideris, J., Vanderbilt, J., & Moskowitz, L. (2012). Perseveration in the connected speech of boys with fragile X syndrome with and without autism spectrum disorder. American Journal on Intellectual and Developmental Disabilities, 117(5), 384–399. PubMedCentralPubMedCrossRef

McDuffie, A., Abbeduto, L., Lewis, P., Kover, S., Kim, J., Weber, A., et al. (2010). Autism spectrum disorder in children and adolescents with fragile X syndrome: Within-syndrome differences and age-related changes. American Journal on Intellectual and Developmental Disabilities, 115(4), 307–326. PubMedCentralPubMedCrossRef

Merenstein, S. A., Sobesky, W. E., Taylor, A. K., Riddle, J. E., Tran, H. X., & Hagerman, R. J. (1996). Molecular-clinical correlations in males with an expanded FMR1 mutation. American Journal of Medical Genetics, 64(2), 388–394. PubMedCrossRef

Mervis, C. B., & Robinson, B. F. (1999). Methodological issues in cross-syndrome comparisons: Matching procedures, sensitivity (Se), and specificity (Sp). Monographs of the Society for Research in Child Development, 64(1), 115–130. PubMedCrossRef

Moss, J., & Howlin, P. (2009). Autism spectrum disorders in genetic syndromes: Implications for diagnosis, intervention and understanding the wider autism spectrum disorder population. Journal of Intellectual Disability Research, 53(10), 852–873. PubMedCrossRef

Munir, F., Cornish, K. M., & Wilding, J. (2000). A neuropsychological profile of attention deficits in young males with fragile X syndrome. Neuropsychologia, 38(9), 1261–1270. PubMedCrossRef

Risi, S., Lord, C., Gotham, K., Corsello, C., Chrysler, C., Szatmari, P., et al. (2006). Combining information from multiple sources in the diagnosis of autism spectrum disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 1094–1103. PubMedCrossRef

Roberts, J., Martin, G., Moskowitz, L., Harris, A., Foreman, J., & Nelson, L. (2007a). Discourse skills of boys with fragile X syndrome in comparison to boys with Down syndrome. Journal of Speech, Language and Hearing Research, 50(2), 475. CrossRef

Roberts, J., Weisenfeld, L., Hatton, D., Heath, M., & Kaufmann, W. (2007b). Social approach and autistic behavior in children with fragile X syndrome. Journal of Autism and Developmental Disorders, 37(9), 1748–1760. PubMedCrossRef

Rogers, S., Wehner, E., & Hagerman, R. (2001). The behavioral phenotype in fragile X: Symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders. Journal of Developmental and Behavioral Pediatrics, 22(6), 409–417. PubMedCrossRef

Roid, G., & Miller, L. (1997). Leiter International Performance Scale—Revised. Wood Dale, IL: Stoelting.

Rutter, M., LeCouteur, A., & Lord, C. (2008). Autism diagnostic interview-revised (ADI-R). Los Angeles, CA: Western Psychological Services.

Skinner, M., Hooper, S., Hatton, D. D., Roberts, J., Mirrett, P., Schaaf, J., et al. (2005). Mapping nonverbal IQ in young boys with fragile X syndrome. American Journal of Medical Genetics, 132(1), 25–32. CrossRef

Smith, L. E., Barker, E. T., Seltzer, M. M., Abbeduto, L., & Greenberg, J. S. (2012). Behavioral phenotype of fragile X syndrome in adolescence and adulthood. American Journal on Intellectual and Developmental Disabilities, 117(1), 1–17.

Symons, F. J., Clark, R. D., Hatton, D. D., Skinner, M., & Bailey, D. B. (2003). Self-injurious behavior in young boys with fragile X syndrome. American Journal of Medical Genetics Part A, 118(2), 115–121.

Tranfaglia, M. (2012). Fragile X syndrome: A psychiatric perspective. In R. B. Denman (Ed.), Modeling fragile X syndrome (pp. 281–296). Berlin: Springer.

Turk, J. (1998). Fragile X syndrome and attentional deficits. Journal of Applied Research in Intellectual Disabilities, 11(3), 175–191. CrossRef

Verkerk, A. J., Pieretti, M., Sutcliffe, J. S., Fu, Y. H., Kuhl, D. P., Pizzuti, A., et al. (1991). Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell, 65, 905. PubMedCrossRef

Wolff, J. J., Bodfish, J. W., Hazlett, H. C., Lightbody, A. A., Reiss, A. L., & Piven, J. (2012). Evidence of a distinct behavioral phenotype in young boys with fragile X syndrome and autism. Journal of the American Academy of Child and Adolescent Psychiatry, 51(12), 1324–1332. PubMedCentralPubMedCrossRef

Titel: Symptoms of Autism in Males with Fragile X Syndrome: A Comparison to Nonsyndromic ASD Using Current ADI-R Scores
Auteurs:: Andrea McDuffie
Angela John Thurman
Randi J. Hagerman
Leonard Abbeduto
Publicatiedatum: 01-07-2015
DOI: https://doi.org/10.1007/s10803-013-2013-6
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 7/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Tip

Swipe om te navigeren naar een ander artikel

Abstract

Log in om toegang te krijgen

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Psychologie Totaal

Andere artikelen Uitgave 7/2015

Interpretation of Logical Words in Mandarin-Speaking Children with Autism Spectrum Disorders: Uncovering Knowledge of Semantics and Pragmatics

Computer-Assisted Face Processing Instruction Improves Emotion Recognition, Mentalizing, and Social Skills in Students with ASD

Clinical Outcomes of Behavioral Treatments for Pica in Children with Developmental Disabilities

The Development of Coordinated Communication in Infants at Heightened Risk for Autism Spectrum Disorder

Compassionate Parenting as a Key to Satisfaction, Efficacy and Meaning Among Mothers of Children with Autism

Preliminary Effectiveness of Project ImPACT: A Parent-Mediated Intervention for Children with Autism Spectrum Disorder Delivered in a Community Program