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Gepubliceerd in:

02-02-2022

Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy

Auteurs: Blanca Noriega Esquives, Tae K. Lee, Patricia I. Moreno, Rina S. Fox, Betina Yanez, Gregory E. Miller, Ryne Estabrook, Mark J. Begale, Sarah C. Flury, Kent Perry, Shilajit D. Kundu, Frank J. Penedo

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 3/2022

Abstract

To identify symptom burden profiles among men with advanced prostate cancer undergoing androgen-deprivation therapy and examine their association with baseline sociodemographic and medical characteristics and psychosocial outcomes over time. Latent profile analysis was employed to identify distinct groups based on the Expanded Prostate Index Composite and the McGill Pain Questionnaire at baseline. Psychosocial outcomes were assessed at baseline, 6- and 12-month follow-ups. Three profiles emerged: “high symptom burden,” “high sexual bother,” and “low symptom burden.” Men with “high symptom burden” were younger and exhibited higher baseline levels of depression, stress, cancer-specific distress, and anxiety than men in the other two groups. However, men with “high symptom burden” also demonstrated improvement in these psychosocial outcomes over time. Men with advanced prostate cancer who experience multiple co-occurring symptoms demonstrate worse psychosocial adjustment. Patients with substantial symptom burden, and specifically young men, may benefit from prompt referral to supportive care services.

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Titel: Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy
Auteurs: Blanca Noriega Esquives
Tae K. Lee
Patricia I. Moreno
Rina S. Fox
Betina Yanez
Gregory E. Miller
Ryne Estabrook
Mark J. Begale
Sarah C. Flury
Kent Perry
Shilajit D. Kundu
Frank J. Penedo
Publicatiedatum: 02-02-2022
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 3/2022
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-022-00288-4

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