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01-08-2011 | Original Article

Still Struggling: Characteristics of Youth With OCD Who are Partial Responders to Medication Treatment

Auteurs: J. Freeman, J. Sapyta, A. Garcia, D. Fitzgerald, M. Khanna, M. Choate-Summers, P. Moore, A. Chrisman, N. Haff, A. Naeem, J. March, M. Franklin

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 4/2011

Abstract

The primary aim of this paper is to examine the characteristics of a large sample of youth with OCD who are partial responders (i.e., still have clinically significant symptoms) to serotonin reuptake inhibitor (SRI) medication. The sample will be described with regard to: demographics, treatment history, OCD symptoms/severity, family history and parental psychopathology, comorbidity, and global and family functioning. The sample includes 124 youth with OCD ranging in age from 7 to 17 with a primary diagnosis of OCD and a partial response to an SRI medication. The youth are a predominantly older (age 12 and over), Caucasian, middle to upper income group who had received significant past treatment. Key findings include moderate to severe OCD symptoms, high ratings of global impairment, and significant comorbidity, despite partial response to an adequate medication trial. Considerations regarding generalizability of the sample and limitations of the study are discussed.

vorige artikel The Effectiveness of Parent–Child Interaction Therapy with Depressive Mothers: The Changing Relationship as the Agent of Individual Change

volgende artikel A Multivariate Model of Parent–Adolescent Relationship Variables in Early Adolescence

Current research diagnostic criteria for PANDAS require at least 2 prospectively documented episodes of exacerbations in OCD symptomatology associated with streptococcal infection. To protect against confounding by PANDAS, participants who met research diagnostic criteria for PANDAS and/or who were on an ongoing antibiotic regimen for treatment (or prophylaxis) of OCD, tic symptoms or rheumatic fever were excluded. Once randomized, subjects with group A β-hemolytic streptococcal (GABHS) infections were cared for by their primary care physician as appropriate for the management of GABHS.

The category of ADHD meds included stimulants and Atomoxetine. Use of other antidepressants included trazodone, imipramine, and mirazapine. Anticonvulsants included carbamazepine, tigabine, topiramate, oxcarbazepine, divalproex sodium, and pimozide. Examples of other permitted medications not mentioned above were for asthma (e.g., abuterol, fluticasone), allergies (e.g., cetirizine, loratadine) or sleep (e.g., eszopiclone, zolpidem).

It is important to clarify that this was based solely on parent report. We did not utilize a clinician administered interview to assess age of onset of first OCD symptoms.

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Titel: Still Struggling: Characteristics of Youth With OCD Who are Partial Responders to Medication Treatment
Auteurs: J. Freeman
J. Sapyta
A. Garcia
D. Fitzgerald
M. Khanna
M. Choate-Summers
P. Moore
A. Chrisman
N. Haff
A. Naeem
J. March
M. Franklin
Publicatiedatum: 01-08-2011
Uitgeverij: Springer US
Gepubliceerd in: Child Psychiatry & Human Development / Uitgave 4/2011
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI: https://doi.org/10.1007/s10578-011-0227-4

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