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Gepubliceerd in:

01-04-2007 | Original Paper

Spatial Working Memory Deficits in Autism

Auteurs: Shelly D. Steele, Nancy J. Minshew, Beatriz Luna, John A. Sweeney

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2007

Abstract

Previous studies have reported working memory deficits in autism, but this finding has been inconsistent. One possibility is that deficits in this domain may be present only when working memory load exceeds some limited capacity. High-functioning individuals with autism performed the CANTAB computerized test of spatial working memory. Individuals with autism made more errors than a matched group of typically developing controls on this task, and were less likely to consistently use a specific organized search strategy to complete the task. Overall, these results demonstrate reduced spatial working memory abilities in autism, and extend previous findings by demonstrating that these deficits are significant when tasks impose heavier demands on working memory.

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volgende artikel The Autism Diagnostic Observation Schedule: Revised Algorithms for Improved Diagnostic Validity

Ameli, R., Courchesne, E., Lincoln, A., Kaufman, A. S., & Grillon, C. (1988). Visual memory processes in high-functioning individuals with autism. Journal of Autism and Developmental Disorders, 18, 601–615. PubMedCrossRef

Baddeley, A. (1986). Working memory: Theory and practice. New York: Oxford University Press.

Bennetto, L., Pennington, B. F., & Rogers, S. J. (1996). Intact and impaired memory functions in autism. Child Development, 67, 1816–1835. PubMedCrossRef

Carlson, S., Martinkauppi, S., Raemae, P., Salli, E., Korvenoja, K., & Aronen, H. J. (1998). Distribution of cortical activation during visuospatial n-back tasks as revealed by functional magnetic resonance imaging. Cerebral Cortex, 8, 743–752. PubMedCrossRef

Diamond, A., Prevor, M. B., Callender, G., & Druin, D. P. (1997). Prefrontal cortex cognitive deficits in children treated early and continuously for PKU. Monographs of the Society for Research in Child Development, 62, 1–208. CrossRef

Fletcher, P. C., & Henson, R. N. (2001). Frontal lobes and human memory: Insights from functional neuroimaging. Brain, 124, 849–881. PubMedCrossRef

Fuster, J. M. (2000). Prefrontal neurons in networks of executive memory. Brain Research Bulletin, 52, 331–336. PubMedCrossRef

Griffith, E. M., Pennington, B. F., Wehner, E. A., & Rogers, S. J. (1999). Executive functions in young children with autism. Child Development, 70, 817–832. PubMedCrossRef

Goldman-Rakic, P. S. (1988). Topography of cognition: Parallel distributed networks in primate association cortex. Annual Review of Neuroscience, 11, 137–156. PubMedCrossRef

Hollingshead A. B., & Redlich, F. C. (1958). Social class and mental illness. New York: John Wiley & Sons.

Horwitz, B., Rumsey, J. M., Grady, C. L., & Rapoport, S. I. (1988). The cerebral metabolic landscape in autism. Archives of Neurology, 45, 749–755. PubMed

Hughes, C., Leboyer, M., & Bouvard, M. (1997). Executive function in parents of children with autism. Psychological Medicine, 27, 209–220. PubMedCrossRef

Hughes, C., & Russell, J. (1993). Autistic children’s difficulty with mental disengagement from an object: Its implications for theories of autism. Developmental Psychology, 29, 498–510. CrossRef

Hughes, C., Russell, J., & Robbins, T. W. (1994). Evidence for executive dysfunction in autism. Neuropsychologia, 32, 477–492. PubMedCrossRef

Joseph, R. M., Steele, S. D., Meyer, E., & Tager-Flusberg, H. (2005). Self-ordered pointing in children with autism: Failure to use verbal mediation in the service of working memory. Neuropsychologia, 43, 1400–1411. PubMedCrossRef

Koczat, D. L., Rogers, S. J., Pennington, B. F., & Ross, R. G. (2002). Eye movement abnormality suggestive of a spatial working memory deficit is present in parents of autistic probands. Journal of Autism and Developmental Disorders, 32, 513–518. PubMedCrossRef

Le Couteur, A., Rutter, M., Lord, C., Rios, P., Robertson, S., Holdgrafer, M., & McLennan, J. (1989). Autism diagnostic interview: A standardized investigator-based instrument. Journal of Autism and Developmental Disorders, 19, 363–387. PubMedCrossRef

Lord, C., Risi, S., Lambrecht, L., Cook, E. H. Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223. PubMedCrossRef

Lord, C., Rutter, M., & Couteur, A. L. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685. PubMedCrossRef

Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., & Schopler, E. (1989). Autism diagnostic observation schedule: A standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders, 19, 185–212. PubMedCrossRef

Luna, B., Minshew, N. J., Garver, K., Lazar, N. A., Thulborn, K. R., Eddy, W. F. et al. (2002). Neocortical system abnormalities in autism: An fMRI study of spatial working memory. Neurology, 59, 834–840. PubMed

McCarthy, G., Blamire, A. M., Puce, A., Nobre, A. C., Bloch, G., Hyder, F., et al. (1994). Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task. Proceedings of the National Academy of Sciences of the United States of America, 91, 8690–8694. PubMedCrossRef

Minshew, N. J., & Goldstein, G. (1993). Is autism an amnesic disorder? Evidence from the California Verbal Learning Test. Neuropsychology, 7, 209–216. CrossRef

Minshew, N. J., & Goldstein, G. (1998). Autism as a disorder of complex information processing. Mental Retardation and Developmental Disabilities Research Reviews, 4, 129–136. CrossRef

Minshew, N. J., & Goldstein, G. (2001). The pattern of intact and impaired memory functions in autism. Journal of Child Psychology and Psychiatry and Allied Disciplines, 42, 1095–1101.

Minshew, N. J., Luna, B., & Sweeney, J. A. (1999). Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism. Neurology, 52, 917–922. PubMed

Morris, R. G., Rowe, A., Fox, N., Feigenbaum, J. D., Miotto, E. C., & Howlin, P. (1999). Spatial working memory in Asperger’s syndrome and in patients with focal frontal and temporal lobe lesions. Brain and Cognition, 41, 9–26. PubMedCrossRef

Ohnishi, T., Matsuda, H., Hashimoto, T., Kunihiro, T., Nishikawa, M., Uema, T. et al. (2000). Abnormal regional cerebral blood flow in childhood autism. Brain, 123, 1838–1844. PubMedCrossRef

Owen, A. M., Evans, A. C., & Petrides, M. (1996). Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: A positron emission tomography study. Cerebral Cortex, 6, 31–38. PubMedCrossRef

Owen, A. M., Downes, J. J., Sahakian, B. J., Polkey, C. E., & Robbins, T. W. (1990). Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia, 28, 1021–1034. PubMedCrossRef

Owen, A. M., Morris, R. G., Sahakian, B. J., Polkey, C. E., & Robbins, T. W. (1996). Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man. Brain, 119, 1597–1615. PubMedCrossRef

Ozonoff, S., & Jensen, J. (1999). Brief report: Specific executive function profiles in three neurodevelopmental disorders. Journal of Autism and Developmental Disorders, 29, 171–177. PubMedCrossRef

Ozonoff, S., Pennington, B. F., & Rogers, S. J. (1991). Executive function deficits in high-functioning autistic individuals: Relationship to theory of mind. Journal of Child Psychology and Psychiatry, 32, 1081–1105. PubMedCrossRef

Ozonoff, S., & Strayer, D. L. (2001). Further evidence of intact working memory in autism. Journal of Autism and Developmental Disorders, 31, 257–263. PubMedCrossRef

Papoulis, A. (1990). Probability and statistics. Prentence-Hall International Editions.

Pierrot-Deseilligny, C., Rivaud, S., Gaymard, B., Muri, R., & Vermersch, A. I. (1995). Cortical control of saccades. Annals of Neurology, 37, 557–567. PubMedCrossRef

Robbins, T. W., James, M., Owen, A. M., Sahakian, B. J., McInnes, L., & Rabbitt, P. (1994). Cambridge neuropsychological test automated battery (CANTAB): A factor analytic study of a large sample of normal elderly volunteers. Dementia, 5, 266–281. PubMed

Sweeney, J. A., Mintun, M. A., Kwee, S., Wiseman, M. B., Brown, D. L., & Rosenberg, D. R. et al. (1996). Positron emission tomography study of voluntary saccadic eye movements and spatial working memory. Journal of Neurophysiology, 75, 454–468. PubMed

Tabachnik, B. G., & Fidell, L. S. (1989). Using multivariate statistics (2nd ed.). New York: Harper and Row.

Zilbovicius, M., Garreau, B., Samsom, Y., Remy, P., Barthelemy, C., & Syrota, A. et al. (1995). Delayed maturation of the frontal cortex in childhood autism. American Journal of Psychiatry, 152, 248–252. PubMed

Titel: Spatial Working Memory Deficits in Autism
Auteurs: Shelly D. Steele
Nancy J. Minshew
Beatriz Luna
John A. Sweeney
Publicatiedatum: 01-04-2007
Uitgeverij: Kluwer Academic Publishers-Plenum Publishers
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 4/2007
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-006-0202-2

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