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Gepubliceerd in:

18-02-2020

Social support moderates D-dimer and self-rated successful aging within people with HIV and older adults

Auteurs: Ni Sun-Suslow, Elizabeth Pasipanodya, Erin Morgan, Maulika Kohli, Vanessa Serrano, Scott Letendre, Dilip V. Jeste, David J. Moore

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 6/2020

Abstract

Many factors can influence perceptions of successful aging (SA), including social isolation and poor physical health. We hypothesized that social support attenuates the negative effect of plasma D-dimer, a correlate of HIV and aging, on SA. Participants included 230 adults (134 people with HIV; PWH, 96 HIV−), ages 36–65, segregated into age cohorts with up to 5 yearly visits. Multilevel modeling examined longitudinal within-person associations between D-dimer, social support, and SA. Social support moderated the relationship between D-dimer and SA and was significant among PWH and older individuals (ages 56–65), but not HIV− or younger cohorts. This association was significant only at extreme levels of social support, with significant decreases in social support potentiating the negative impact of D-dimer on SA and significant increases in social support facilitating increased SA. Despite declining health, high social support may improve SA in PWH and older adults, and low support may be especially problematic for older adults.

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Antiretroviral Therapy Cohort Collaboration. (2017). Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: A collaborative analysis of cohort studies. Lancet HIV, 4, e349–e356. https://doi.org/10.1016/S2352-3018(17)30066-8CrossRef

Borges, A. H., O’Connor, J. L., Phillips, A. N., Baker, J. V., Vjecha, M. J., Losso, M. H., et al. (2014). Factors associated with D-Dimer levels in HIV-infected individuals. PLoS ONE, 9, e90978. https://doi.org/10.1371/journal.pone.0090978CrossRefPubMedPubMedCentral

Calmy, A., Gayet-Ageron, A., Montecucco, F., Nguyen, A., Mach, F., Burger, F., et al. (2009). HIV increases markers of cardiovascular risk: Results from a randomized, treatment interruption trial. AIDS, 23, 929–939. https://doi.org/10.1097/QAD.0b013e32832995faCrossRefPubMed

Carr, J. M., McKinney, M., & McDonagh, J. (1989). Diagnosis of disseminated intravascular coagulation Role of D-dimer. American Journal of Clinical Pathology, 91, 280–287. https://doi.org/10.1093/ajcp/91.3.280CrossRefPubMed

Colombo, G., Furlan, L., & Colombo, G. (2014). Age-adjusted D-dimer cutoff levels and pulmonary embolism. JAMA, 312, 557. https://doi.org/10.1001/jama.2014.7604CrossRefPubMed

De Francesco, D., Wit, F. W., Burkle, A., Oehlke, S., Kootstra, N. A., Winston, A., et al. (2019). Do people living with HIV experience greater age advancement than their HIV-negative counterparts? AIDS, 33, 259–268. https://doi.org/10.1097/QAD.0000000000002063CrossRefPubMed

Depp, C. A., & Jeste, D. V. (2006) Definitions and predictors of successful aging: A comprehensive review of larger quantitative studies. The American Journal of Geriatric Psychiatry, 14, 6–20. https://doi.org/10.1097/01.JGP.0000192501.03069.bcCrossRefPubMed

Di Castelnuovo, A., de Curtis, A., Costanzo, S., Persichillo, M., Olivieri, M., Zito, F., et al. (2013). Association of D-dimer levels with all-cause mortality in a healthy adult population: Findings from the MOLI-SANI study. Haematologica, 98, 1476–1480. https://doi.org/10.3324/haematol.2012.083410CrossRefPubMedPubMedCentral

Earnshaw, V. A., Lang, S. M., Lippitt, M., Jin, H., & Chaudoir, S. R. (2015). HIV stigma and physical health symptoms: Do social support, adaptive coping, and/or identity centrality act as resilience resources? AIDS and Behavior, 19, 41–49. https://doi.org/10.1007/s10461-014-0758-3CrossRefPubMedPubMedCentral

El-Sadr, W. M., Lundgren, J., Neaton, J. D., Gordin, F., Abrams, D., Arduino, R. C., et al. (2006). CD4 + count-guided interruption of antiretroviral treatment. New England Journal of Medicine, 355, 2283–2296. https://doi.org/10.1056/NEJMoa062360CrossRefPubMed

Emlet, C. A. (2016). Social, economic, and health disparities among LGBT older adults. Generations, 40, 16–22.PubMedPubMedCentral

Fazeli, P. L., Montoya, J. L., McDavid, C. N., & Moore, D. J. (2018). Older HIV+ and HIV− adults provide similar definitions of successful aging: A mixed-methods examination. The Gerontologist. https://doi.org/10.1371/journal.pone.0090978CrossRef

Fumaz, C. R., Ayestaran, A., Perez-Alvarez, N., Munoz-Moreno, J. A., Molto, J., Ferrer, M. J., et al. (2015). Resilience, ageing, and quality of life in long-term diagnosed HIV-infected patients. Aids Care-Psychological and Socio-Medical Aspects of AIDS/HIV, 27, 1396–1403. https://doi.org/10.1080/09540121.2015.1114989CrossRef

Gardiner, C., Geldenhuys, G., & Gott, M. (2018). Interventions to reduce social isolation and loneliness among older people: An integrative review. Health and Social Care in the Community, 26, 147–157. https://doi.org/10.1111/hsc.12367CrossRefPubMed

Gow, A. J., Pattie, A., Whiteman, M. C., Whalley, L. J., & Deary, I. J. (2007). Social support and successful aging: Investigating the relationships between lifetime cognitive change and life satisfaction. Journal of Individual Differences, 28, 103–115. https://doi.org/10.1027/1614-0001.28.3.103CrossRef

Harper, P. L., Theakston, E., Ahmed, J., & Ockelford, P. (2007). D-dimer concentration increases with age reducing the clinical value of the D-dimer assay in the elderly. Intern Med J, 37, 607–613. https://doi.org/10.1111/j.1445-5994.2007.01388.xCrossRefPubMed

Holt-Lunstad, J., Robles, T. F., & Sbarra, D. A. (2017). Advancing social connection as a public health priority in the United States. American Psychologist, 72, 517–530. https://doi.org/10.1037/amp0000103CrossRefPubMed

Howie, L. O., Troutman-Jordan, M., & Newman, A. M. (2014). Social support and successful aging in assisted living residents. Educational Gerontology, 40, 61–70. https://doi.org/10.1080/03601277.2013.768085CrossRef

Huang, Y., Yim, O. S., Lai, P. S., Yu, R., Chew, S. H., Gwee, X., et al. (2019). Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length. Psychoneuroendocrinology, 103, 180–187. https://doi.org/10.1016/j.psyneuen.2019.01.015CrossRefPubMed

Idler, E. L., & Benyamini, Y. (1997). Self-rated health and mortality: A review of twenty-seven community studies. Journal of Health and Social Behavior, 38, 21–37.CrossRef

Jeste, D. V., & Palmer, B. W. (2013). A call for a new positive psychiatry of ageing. British Journal of Psychiatry, 202, 81–83. https://doi.org/10.1192/bjp.bp.112.110643CrossRef

Jeste, D. V., Savla, G. N., Thompson, W. K., Vahia, I. V., Glorioso, D. K., Martin, A. V. S., et al. (2013). Association between older age and more successful aging: Critical role of resilience and depression. American Journal of Psychiatry, 170, 188–196. https://doi.org/10.1176/appi.ajp.2012.12030386CrossRefPubMed

Johnson, P. O., & Fay, L. C. (1950). The Johnson–Neyman technique, its theory and application. Psychometrika, 15, 349–367. https://doi.org/10.1007/bf02288864CrossRefPubMed

Johnson, P. O., & Neyman, J. (1936). Tests of certain linear hypotheses and their application to some educational problems. Statistical Research Memoirs, 1, 57–93.

Khoury, A. L., Morey, M. C., Wong, T. C., McNeil, D. L., Humphries, B., Frankey, K., et al. (2017). Diminished physical function in older HIV-infected adults in the Southeastern U.S. despite successful antiretroviral therapy. PLoS ONE, 12, e0179874. https://doi.org/10.1371/journal.pone.0179874CrossRefPubMedPubMedCentral

Koenig, H. G., Westlund, R. E., George, L. K., Hughes, D. C., Blazer, D. G., & Hybels, C. (1993). Abbreviating the duke social support index for use in chronically ill elderly individuals. Psychosomatics, 34, 61–69. https://doi.org/10.1016/S0033-3182(93)71928-3CrossRefPubMed

Kuller, L. H., Tracy, R., Belloso, W., De Wit, S., Drummond, F., Lane, H. C., et al. (2008). Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med, 5, e203. https://doi.org/10.1371/journal.pmed.0050203CrossRefPubMedPubMedCentral

Malaspina, L., Woods, S. P., Moore, D. J., Depp, C., Letendre, S. L., Jeste, D., et al. (2011). Successful cognitive aging in persons living with HIV infection. Journal of Neurovirology, 17, 110–119. https://doi.org/10.1007/s13365-010-0008-zCrossRefPubMed

Meanley, S. P., Stall, R. D., Hawk, M. E., Surkan, P. J., Shoptaw, S. J., Matthews, D. D., et al. (2019). Multifactorial discrimination, discrimination salience, and prevalent experiences of internalized homophobia in middle-aged and older MSM. Aging Ment Health. https://doi.org/10.1080/13607863.2019.1594161CrossRefPubMed

Montross, L. P., Depp, C., Daly, J., Reichstadt, J., Golshan, S., Moore, D., et al. (2006). Correlates of self-rated successful aging among community-dwelling older adults. Am J Geriatr Psychiatry, 14, 43–51. https://doi.org/10.1097/01.JGP.0000192489.43179.31CrossRefPubMed

Moore, R. C., Eyler, L. T., Mausbach, B. T., Zlatar, Z. Z., Thompson, W. K., Peavy, G., et al. (2015). Complex interplay between health and successful aging: Role of perceived stress, resilience, and social support. The American Journal of Geriatric Psychiatry, 23, 622–632. https://doi.org/10.1016/j.jagp.2014.08.004CrossRefPubMed

Moore, D. J., Fazeli, P. L., Moore, R. C., Woods, S. P., Letendre, S. L., Jeste, D. V., et al. (2018). Positive psychological factors are linked to successful cognitive aging among older persons living with HIV/AIDS. AIDS and Behavior, 22, 1551–1561. https://doi.org/10.1007/s10461-017-2001-5CrossRefPubMedPubMedCentral

Moore, R. C., Moore, D. J., Thompson, W. K., Vahia, I. V., Grant, I., & Jeste, D. V. (2013). A case-controlled study of successful aging in older HIV-infected adults. Journal of Clinical Psychiatry, 74, e417–e423. https://doi.org/10.4088/JCP.12m08100CrossRefPubMed

Moore, R. C., Fazeli, P. L., Jeste, D. V., Moore, D. J., Grant, I., Woods, S. P., et al. (2014). Successful cognitive aging and health-related quality of life in younger and older adults infected with HIV. Aids and Behavior, 18, 1186–1197. https://doi.org/10.1007/s10461-014-0743-xCrossRefPubMedPubMedCentral

Muthén, B., & Muthén, L. (1998–2015). Mplus User’s Guide. Seventh Edition. Los Angeles, CA: Muthén & Muthén.

Nasi, M., De Biasi, S., Gibellini, L., Bianchini, E., Pecorini, S., Bacca, V., et al. (2017). Ageing and inflammation in patients with HIV infection. Clinical and Experimental Immunology, 187, 44–52. https://doi.org/10.1111/cei.12814CrossRefPubMed

Nosraty, L., Pulkki, J., Raitanen, J., Enroth, L., & Jylhä, M. (2019). Successful aging as a predictor of long-term care among oldest old: The vitality 90+ study. Journal of Applied Gerontology, 38, 553–571. https://doi.org/10.1177/0733464817716968CrossRefPubMed

Phelan, E. A., & Larson, E. B. (2002). “Successful aging”–where next? Journal of the American Geriatrics Society, 50, 1306–1308. https://doi.org/10.1046/j.1532-5415.2002.t01-1-50324.xCrossRefPubMed

Reblin, M., & Uchino, B. N. (2008). Social and emotional support and its implication for health. Current Opinion in Psychiatry, 21, 201. https://doi.org/10.1097/YCO.0b013e3282f3ad89CrossRefPubMedPubMedCentral

Reichstadt, J., Sengupta, G., Depp, C. A., Palinkas, L. A., & Jeste, D. V. (2010). Older adults’ perspectives on successful aging: Qualitative interviews. The American Journal of Geriatric Psychiatry, 18, 567–575. https://doi.org/10.1097/jgp.0b013e3181e040bbCrossRefPubMedPubMedCentral

Rooney, A. S., Moore, R. C., Paolillo, E. W., Gouaux, B., Umlauf, A., Letendre, S. L., et al. (2019). Depression and aging with HIV: Associations with health-related quality of life and positive psychological factors. Journal of Affective Disorders, 251, 1–7. https://doi.org/10.1016/j.jad.2019.03.025CrossRefPubMedPubMedCentral

Rowe, J. W., & Kahn, R. L. (1997). Successful aging. Gerontologist, 37, 433–440. https://doi.org/10.1093/geront/37.4.433CrossRefPubMed

Rubtsova, A. A., Wingood, G. M., Ofotokun, I., Gustafson, D., Vance, D. E., Sharma, A., et al. (2019). Prevalence and correlates of self-rated successful aging among older women living with HIV. Journal of Acquired Immune Deficiency Syndromes, 82, S162–S169. https://doi.org/10.1097/QAI.0000000000002175CrossRefPubMed

Rueda, S., Law, S., & Rourke, S. B. (2014). Psychosocial, mental health, and behavioral issues of aging with HIV. Current Opinion in HIV AIDS, 9, 325–331. https://doi.org/10.1097/COH.0000000000000071CrossRefPubMed

Seeman, T. E., Lusignolo, T. M., Albert, M., & Berkman, L. (2001). Social relationships, social support, and patterns of cognitive aging in healthy, high-functioning older adults: MacArthur studies of successful aging. Health Psychology, 20, 243–255. https://doi.org/10.1037//0278-6133.20.4.243CrossRefPubMed

Smit, M., Brinkman, K., Geerlings, S., Smit, C., Thyagarajan, K., Sighem, A., et al. (2015). Future challenges for clinical care of an ageing population infected with HIV: A modelling study. The Lancet Infectious Diseases, 15, 810–818. https://doi.org/10.1016/S1473-3099(15)00056-0CrossRefPubMedPubMedCentral

Stewart, J. M., Auais, M., Belanger, E., & Philips, S. P. (2019). Comparison of self-rated and objective successful ageing in an international cohort. Ageing & Society, 39, 1317–1334. https://doi.org/10.1017/S0144686X17001489CrossRef

Strawbridge, W. J., Wallhagen, M. I., & Cohen, R. D. (2002). Successful aging and well-being: self-rated compared with Rowe and Kahn. Gerontologist, 42, 727–733. https://doi.org/10.1093/geront/42.6.727CrossRefPubMed

Vance, D. E., Blake, B. J., Brennan-Ing, M., DeMarco, R. F., Fazeli, P. L., & Relf, M. V. (2019). Revisiting successful aging With HIV through a revised biopsychosocial model: An update of the literature. Journal of the Association of Nurses in AIDS Care, 30, 5–14. https://doi.org/10.1097/JNC.0000000000000029CrossRefPubMed

Wallace, L. M. K., Ferrara, M., Brothers, T. D., Garlassi, S., Kirkland, S. A., Theou, O., et al. (2017). Lower frailty is associated with successful cognitive aging among older adults with HIV. AIDS Research and Human Retroviruses, 33, 157–163. https://doi.org/10.1089/aid.2016.0189CrossRefPubMedPubMedCentral

Titel: Social support moderates D-dimer and self-rated successful aging within people with HIV and older adults
Auteurs: Ni Sun-Suslow
Elizabeth Pasipanodya
Erin Morgan
Maulika Kohli
Vanessa Serrano
Scott Letendre
Dilip V. Jeste
David J. Moore
Publicatiedatum: 18-02-2020
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 6/2020
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-020-00141-6

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