TODO: Skip to main content
Top
Gepubliceerd in:

04-05-2018 | Original Paper

Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder

Auteurs: Molly B. D. Prigge, Erin D. Bigler, Brittany G. Travers, Alyson Froehlich, Tracy Abildskov, Jeffrey S. Anderson, Andrew L. Alexander, Nicholas Lange, Janet E. Lainhart, Brandon A. Zielinski

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2018

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

The relationship between brain development and clinical heterogeneity in autism (ASD) is unknown. This study examines the Social Responsiveness Scale (SRS) in relation to the longitudinal development of cortical thickness. Participants (N = 91 ASD, N = 56 TDC; 3–39 years at first scan) were scanned up to three times over a 7-year period. Mixed-effects models examined cortical thickness in relation to SRS score. ASD participants with higher SRS scores showed regionally increased age-related cortical thinning. Regional thickness differences and reduced age-related cortical thinning were found in predominantly right lateralized regions in ASD with decreasing SRS scores over time. Our findings emphasize the importance of examining clinical phenotypes in brain-based studies of ASD.
Bijlagen
Deze inhoud is alleen zichtbaar als je bent ingelogd en de juiste rechten hebt.
Literatuur
Deze inhoud is alleen zichtbaar als je bent ingelogd en de juiste rechten hebt.
Metagegevens
Titel
Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder
Auteurs
Molly B. D. Prigge
Erin D. Bigler
Brittany G. Travers
Alyson Froehlich
Tracy Abildskov
Jeffrey S. Anderson
Andrew L. Alexander
Nicholas Lange
Janet E. Lainhart
Brandon A. Zielinski
Publicatiedatum
04-05-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 10/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-018-3566-1