Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

04-06-2019 | Original Paper

Social Avoidance Emerges in Infancy and Persists into Adulthood in Fragile X Syndrome

Auteurs: Jane Roberts, Hayley Crawford, Abigail L. Hogan, Amanda Fairchild, Bridgette Tonnsen, Alexis Brewe, Shannon O’Connor, Douglas A. Roberts, Leonard Abbeduto

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2019

Abstract

Fragile X syndrome (FXS) is characterized by both social approach and social avoidance. However, the age of emergence and developmental trajectory of social avoidance has not been examined. This study investigates the longitudinal developmental trajectory and dynamic nature of social avoidance in males with FXS from infancy through young adulthood (n = 191). Multiple facets of social avoidance were collected using the Social Avoidance Scale (Roberts et al. 2007, 2009). Overall, 81% of males with FXS displayed social avoidance, which emerged during infancy, increased in severity across childhood, and stabilized through adolescence and early adulthood. An exaggerated “warm up” effect was also observed in FXS. This study delineates the complex profile of social avoidance, a common and impairing behavioral feature of FXS.

vorige artikel Developing a Diagnostic Algorithm for the Music-Based Scale for Autism Diagnostics (MUSAD) Assessing Adults with Intellectual Disability

volgende artikel Concurrent Social Communication Predictors of Expressive Language in Minimally Verbal Children and Adolescents with Autism Spectrum Disorder

Achenbach, T. M., & Rescorla, L. A. (2000). Manual for the ASEBA preschool forms & profiles: An integrated system of multi-informant assessment. Burlington: University of Vermont, Research Center for Children, Youth & Families.

Baker, S., Hooper, S., Skinner, M., Hatton, D., Schaaf, J., Ornstein, P., et al. (2011). Working memory subsystems and task complexity in young boys with Fragile X syndrome. Journal of Intellectual Disability Research, 55(1), 19–29.CrossRefPubMed

Beadle-Brown, J., Murphy, G., & Wing, L. (2005). Long-term outcome for people with severe intellectual disabilities: Impact of social impairment. American Journal on Intellectual and Developmental Disabilities, 110(1), 1–12.CrossRef

Bretherton, I., & Ainsworth, M. (1974). Responses of one-year-olds to a stranger in a strange situation. In M. Lewis & L. Rosenblum (Eds.), The origins of fear: The origins of behavior (Vol. 2, pp. 131–164). New York: Wiley.

Brooker, R. J., Buss, K. A., Lemery-Chalfant, K., Aksan, N., Davidson, R. J., & Goldsmith, H. H. (2013). The development of stranger fear in infancy and toddlerhood: Normative development, individual differences, antecedents, and outcomes. Developmental Science, 16, 864–878.PubMedPubMedCentral

Clauss, J., & Blackford, J. (2012). Behavioral inhibition and risk for developing social anxiety disorder: A meta-analytic study. Journal of the American Academy of Child and Adolescent Psychiatry, 51(10), 1066–1075.CrossRefPubMedPubMedCentral

Cohen, I. L., Fisch, G. S., Sudhalter, V., Wolf-Schein, E. G., Hanson, D., Hagerman, R., et al. (1988). Social gaze, social avoidance, and repetitive behavior in fragile X males: A controlled study. American Journal on Mental Retardation, 92(5), 436–446.PubMed

Cornish, K., Turk, J., & Hagerman, R. (2008). The fragile X continuum: New advances and perspectives. Journal of Intellectual Disability Research, 52(6), 469–482.CrossRefPubMed

Crawford, D. C., Acuna, J. M., & Sherman, S. L. (2001). FMR1 and the fragile X syndrome: Human genome epidemiology review. Genetics in Medicine, 3(5), 359–371.CrossRefPubMedPubMedCentral

Ene, M., Leighton, E. A., Blue, G. L., & Bell, B.A. (2015). Proceedings from the SAS Global Forum 2015: Multilevel models for categorical data using SAS PROC GLIMMIX: The basics, paper no. 3430-2015. Cary, NC: SAS Institute Inc.

Esbensen, A. J., Rojahn, J., Aman, M. G., & Ruedrich, S. (2003). Reliability and validity of an assessment instrument for anxiety, depression, and mood among individuals with mental retardation. Journal of Autism and Developmental Disorders, 33(6), 617–629.CrossRefPubMed

Hall, S., DeBernardis, M., & Reiss, A. L. (2006). Social escape behaviors in children with fragile X syndrome. Journal of Autism and Developmental Disorders, 36(7), 935–947.CrossRefPubMed

Hall, S., Lightbody, A. A., Huffman, L. C., Lazzeroni, L. C., & Reiss, A. L. (2009). Physiological correlates of social avoidance behavior in children and adolescents with fragile X syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 48(3), 320–329.CrossRefPubMedPubMedCentral

Hall, S., & Venema, K. (2017). A screening tool to measure eye contact avoidance in boys with fragile X syndrome. Journal of Autism and Developmental Disorders, 47(7), 2254–2264.CrossRefPubMedPubMedCentral

Hall, S. S. (2015). Treatments for fragile X syndrome: A closer look at the data. Journal of Developmental Disabilities Research Reviews, 15(4), 353–360.CrossRef

Hall, S. S., Lightbody, A. A., McCarthy, B. E., Parker, K. J., & Reiss, A. L. (2012). Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome. Psychoneuroendocrinology, 37(4), 509–518.CrossRefPubMed

Hessl, D., Glaser, B., Dyer-Friedman, J., & Reiss, A. L. (2006). Social behavior and cortisol reactivity in children with fragile X syndrome. Journal of Child Psychology and Psychiatry and Allied Disciplines, 47(6), 602–610.CrossRefPubMed

Kaldewaij, R., Koch, S. B., Volman, I., Toni, I., & Roelofs, K. (2017). On the control of social approach-avoidance behavior: Neural and endocrine mechanisms. Current Topics in Behavioral Neuroscience, 30, 275–293.CrossRef

Kampman, O., Viikki, M., Jarventausta, K., & Leinonen, E. (2014). Meta-analysis of anxiety disorders and temperament. Neuropsychobiology, 69(3), 175–186.CrossRefPubMed

Karmiloff-Smith, A., & Farran, E. K. (2011). Williams syndrome: A model for the neuroconstructivist approach. In E. K. Farran & A. Karmiloff-Smith (Eds.), Neurodevelopmental disorders across the lifespan: A neuroconstructivist approach. Oxford: Oxford University Press.

Kau, A. S. M., Meyer, W. A., & Kaufmann, W. E. (2002). Early development in males with Fragile X syndrome: A review of the literature. Microscopy Research and Technique, 57(3), 174–178.CrossRefPubMed

Kau, A. S. M., Reider, E. E., Payne, L., Meyer, W. A., & Freund, L. S. (2000). Early behavior signs of psychiatric phenotypes in fragile X syndrome. American Journal on Mental Retardation, 105(4), 286–299.CrossRefPubMed

Klaiman, C., Quintin, E. M., Jo, B., Lightbody, A. A., Hazlett, H. C., Piven, J., et al. (2014). Longitudinal profiles of adaptive behavior in fragile X syndrome. Pediatrics, 134(2), 315–324.CrossRefPubMedPubMedCentral

Lachiewicz, A. M., Dawson, D. V., & Spiridigliozzi, G. A. (2000). Physical characteristics of young boys with fragile X syndrome: Reasons for difficulties in making a diagnosis in young males. American Journal of Medical Genetics, 92(4), 229–236.CrossRefPubMed

Landa, R. J., Holman, K. C., & Garrett-Mayer, E. (2007). Social and communication development in toddlers with early and later diagnosis of autism spectrum disorders. Archives of General Psychiatry, 64, 853–864.CrossRefPubMed

McLaughlin, K. A., Hatzenbuehler, M. L., Mennin, D. S., & Nolen-Hoeksema, S. (2011). Emotion dysregulation and adolescent psychopathology: A prospective study. Behaviour Research and Therapy, 49(9), 544–554.CrossRefPubMedPubMedCentral

Merenstein, S. A., Sobesky, W. E., Taylor, A. K., Riddle, J. E., Tran, H. X., & Hagerman, R. (1996). Molecular-clinical correlations in males with an expanded FMR1 mutation. American Journal of Medical Genetics, 64(2), 388–394.CrossRefPubMed

Mian, N. D., Carter, A. S., Pine, D. S., Wakschlag, L. S., & Briggs-Gowan, M. J. (2015). Development of a novel observational measure for anxiety in young children: The Anxiety Dimensional Observation Scale. Journal of Child Psychology and Psychiatry and Allied Disciplines, 56(9), 1017–1025.CrossRefPubMed

Miller, A. C., Keenan, J. M., Betjemann, R. S., Willcutt, E., Pennington, B. F., & Olson, R. K. (2013). Reading comprehension in children with ADHD: Cognitive underpinnings of the centrality deficit. Journal of Abnormal Child Psychology, 41(3), 473–483.CrossRefPubMedPubMedCentral

Moskowitz, L. J., & Jones, E. A. (2015). Uncovering the evidence for behavioral interventions with individuals with fragile X syndrome: A systematic review. Research in Developmental Disabilities, 38, 223–241.CrossRef

Mullen, E. M. (1995). Mullen scales of early learning (AGS ed.). Circle Pines, MN: American Guidance Service.

Ouyang, L., Grosse, S., Raspa, M., & Bailey, D. (2010). Employment impact and financial burden for families of children with fragile X syndrome: Findings from the National Fragile X Survey. Journal of Intellectual Disability Research, 54(10), 918–928.CrossRefPubMed

Reichow, B., & Volkmar, F. (2010). Social skills interventions for individuals with autism: Evaluation for evidence-based practices within a best evidence synthesis framework. Journal of Autism and Developmental Disorders, 40(2), 149–166.CrossRefPubMed

Roberts, J. E., Clarke, M. A., Alcorn, K., Carter, J. C., Long, A. C., & Kaufmann, W. E. (2009). Autistic behavior in boys with fragile X syndrome: Social approach and HPA-axis dysfunction. Journal of Neurodevelopmental Disorders, 1(4), 283.CrossRefPubMedPubMedCentral

Roberts, J. E., Crawford, H., Will, E. A., Hogan, A. L., McQuillin, S., Tonnsen, B. L., et al. (2019). Infant social avoidance predicts autism but not anxiety in fragile X syndrome. Frontiers in Psychiatry, 10, 199.CrossRefPubMedPubMedCentral

Roberts, J. E., Ezell, J. E., Fairchild, A. J., Klusek, J., Thurman, A. J., McDuffie, A. et al. (2018). Biobehavioral composite of social aspects of anxiety in young adults with fragile X syndrome contrasted to autism spectrum disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 177(7), 665–675.CrossRef

Roberts, J. E., Tonnsen, B., Robinson, A., & Shinkareva, S. V. (2012). Heart activity and autistic behavior in infants and toddlers with fragile X syndrome. American Journal on Intellectual and Developmental Disabilities, 117(2), 90–102.CrossRefPubMedPubMedCentral

Roberts, J. E., Tonnsen, B. L., McCary, L. M., Caravella, K. E., & Shinkareva, S. V. (2016). Brief report: Autism symptoms in infants with fragile X syndrome. Journal of Autism and Developmental Disorders, 46(12), 3830–3837.CrossRefPubMedPubMedCentral

Roberts, J. E., Weisenfeld, L. A. H., Hatton, D. D., Heath, M., & Kaufmann, W. E. (2007). Social approach and autistic behavior in children with fragile X syndrome. Journal of Autism and Developmental Disorders, 37(9), 1748–1760.CrossRefPubMed

Roid, G. H., & Miller, L. J. (1997). Leiter international performance scale-revised. Wood Dale, IL: Stoelting.

Schneier, F. R., Heckelman, L. R., Garfinkel, R., Campeas, R., Fallon, B. A., Gitow, A., et al. (1994). Functional impairment in social phobia. Journal of Clinical Psychiatry, 55(8), 322–331.PubMed

Schopler, E., Van Bourgondien, M. E., Wellman, G. J., & Love, S. R. (2010). Childhood autism rating scale, second edition (CARS-2): manual. Los Angeles, CA: Western Psychological Services.

Thurman, A. J., McDuffie, A., Hagerman, R., & Abbeduto, L. (2014). Psychiatric symptoms in boys with fragile X syndrome: A comparison with nonsyndromic autism spectrum disorder. Research in Developmental Disabilities, 35(5), 1072–1086.CrossRefPubMedPubMedCentral

Torvik, F. A., Welander-Vatn, A., Ystrom, E., Knudsen, G. P., Czajkowski, N., Kendler, K. S., et al. (2016). Longitudinal associations between social anxiety disorder and avoidant personality disorder: A twin study. Journal of Abnormal Psychology, 125(1), 114–124.CrossRefPubMed

Turner, G., Webb, T., Wake, S., & Robinson, H. (1996). Prevalence of fragile X syndrome. American Journal of Medical Genetics, 64(1), 196–197.CrossRefPubMed

Warren, S. F., Brady, N., Sterling, A., Fleming, K., & Marquis, J. (2010). Maternal responsivity predicts language development in young children with fragile X syndrome. American Journal on Intellectual and Developmental Disabilities, 115(1), 54–75.CrossRefPubMedPubMedCentral

White, S. W., Mazefsky, C. A., Dichter, G. S., Chiu, P. H., Richey, J. A., & Ollendick, T. H. (2014). Social-cognitive, physiological, and neural mechanisms underlying emotion regulation impairments: Understanding anxiety in autism spectrum disorder. International Journal of Developmental Neuroscience, 39, 22–36.CrossRefPubMedPubMedCentral

Williams, T. A., Porter, M. A., & Langdon, R. (2014). Social approach and emotion recognition in fragile X syndrome. American Journal on Intellectual and Developmental Disabilities, 119(2), 133–150.CrossRefPubMed

Zwaigenbaum, L., Bryson, S., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005). Behavioral manifestations of autism in the first year of life. International Journal of Developmental Neuroscience, 23(2-3), 143–152.CrossRefPubMed

Titel: Social Avoidance Emerges in Infancy and Persists into Adulthood in Fragile X Syndrome
Auteurs: Jane Roberts
Hayley Crawford
Abigail L. Hogan
Amanda Fairchild
Bridgette Tonnsen
Alexis Brewe
Shannon O’Connor
Douglas A. Roberts
Leonard Abbeduto
Publicatiedatum: 04-06-2019
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 9/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-019-04051-8

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 9/2019

In Memoriam: Domenic V. Cicchetti, PhD. 1937–2019

Response to ‘Non-complicit: Revisiting Hans Asperger’s Career in Nazi-era Vienna’

Brief Report: Vocabulary and Grammatical Skills of Bilingual Children with Autism Spectrum Disorders at School Age

Effectiveness of Social Stories in Teaching Abduction-Prevention Skills to Children with Autism

Early Life Exposure to Antibiotics and Autism Spectrum Disorders: A Systematic Review

Diagnosis of Autism Spectrum Disorder According to Maternal-Race Ethnicity and Country of Birth: A Register-Based Study