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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-10-2007 | Original Paper

Social Approach and Autistic Behavior in Children with Fragile X Syndrome

Auteurs: Jane E. Roberts, Leigh Anne H. Weisenfeld, Deborah D. Hatton, Morgan Heath, Walter E. Kaufmann

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2007

Abstract

Social avoidance is a core phenotypic characteristic of fragile X syndrome (FXS) that has critical cognitive and social consequences. However, no study has examined modulation of multiple social avoidant behaviors in children with FXS. In the current study, we introduce the Social Approach Scale (SAS), an observation scale that includes physical movement, facial expression, and eye contact approach behaviors collected across multiple time points. Our findings suggested that social approach behaviors in children with FXS were affected by age, gender, setting, and time spent with an examiner. Selected social approach behaviors were related to autistic behavior. Increased eye contact over the course of a research assessment, in particular, was found to be a strong predictor of lower autistic behavior.

vorige artikel Change in Autism Symptoms and Maladaptive Behaviors in Adolescents and Adults with an Autism Spectrum Disorder

volgende artikel The Problem with Using Eye-Gaze to Infer Desire: A Deficit of Cue Inference in Children with Autism Spectrum Disorder?

Achenbach, T. M., & Rescorla, L. A. (2001). Manual for the ASEBA school-age forms and profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, and Families.

Achenbach, T. M., & Rescorla, L. A. (2000). Manual for the ASEBA preschool forms and profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, and Families.

Bailey, D. B., Jr., Hatton, D. D., Skinner, M., & Mesibov, G. (2001). Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome. Journal of Autism and Developmental Disorder, 31, 165–174.

Bailey, D. B., Jr., Mesibov, G. B., Hatton, D. D., Clark, R. D., Roberts, J. E., & Mayhew, L. (1998). Autistic behavior in young boys with fragile X syndrome. Journal of Autism and Developmental Disorders, 28, 499–508.

Bennetto, L., & Pennington, B. F. (2002). Neuropsychology. In R. J. Hagerman & P. J. Hagerman (Eds.), Fragile X syndrome: Diagnosis, treatment, and research, 3 edition. Baltimore, MD: Johns Hopkins University Press, pp. 206–248.

Budimirovic, D., Bukelis, I., Cox, C., Gray, R. M., Tierney, E., & Kaufmann, W. E. (2006). Autism spectrum disorder in fragile X syndrome: Differential contribution of adaptive socialization and social withdrawal. American Journal of Medical Genetics, 140, 1814–1826.PubMed

Cohen, I. L. (1995). Behavioral profiles of autistic and nonautistic fragile X males. Developmental Brain Dysfunction, 8, 252–269.

Cohen, I. L., Fisch, G. S., Sudhalter, V., Wolf-Schein, E. G., Hanson, D., Hagerman, R., Jenkins, E. C., & Brown, W. T. (1988). Social gaze, social avoidance, and repetitive behavior in fragile X males: A controlled study. American Journal on Mental Retardation, 92(5), 436–446.PubMed

Dawson, G., Meltzoff, A. N., Osterling, J., Rinaldi, J., & Brown, E. (1998). Children with autism fail to orient to naturally occurring social stimuli. Journal of Autism and Developmental Disorders, 28, 479–485.PubMedCrossRef

Freund, L. S., Reiss, A. L., & Abrams, M. T. (1993). Psychiatric disorders associated with fragile X in the young female. Pediatrics, 91, 321–329.PubMed

Fullard, W., McDevitt, S. C., & Cary, W. B. (1995). Toddler temperament scale. Scottsdale, AZ: Behavioral-Developmental Initiatives.

Hagerman, R. J. (1992). Clinical conundrums in fragile X syndrome. Nature Genetics, 1, 157–158.PubMedCrossRef

Hagerman, R. J. (2002). The physical and behavioral phenotype. In R. J. Hagerman & P. J. Hagerman (Eds.), Fragile X syndrome: Diagnosis, treatment, and research, 3 edition. Baltimore, MD: Johns Hopkins University Press, pp 206–248.

Hall, S., DeBernardis, M., & Reiss, A. (2006). Social escape behaviors in children with fragile X syndrome. Journal of Autism and Developmental Disorders, 36, 935–947.PubMedCrossRef

Hatton, D. D., Bailey, D. B., Hargett-Beck, M. Q., Skinner, M., & Clark, R. D. (1999). Behavioral style of boys with fragile X syndrome. Developmental Medicine and Child Neurology, 41, 625–632.PubMedCrossRef

Hatton, D. D., Hooper, S. R., Bailey, D. B., Skinner, M. L., Sullivan, K. M., & Wheeler, A. (2002). Problem behavior in boys with fragile X syndrome. American Journal of Medical Genetics, 108, 105–116.PubMedCrossRef

Hatton, D. D., Sideris, J., Skinner, M., Mankowski, J., Bailey, D. B., Roberts, J., et al. (2006). Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP. American Journal of Medical Genetics, 140, 1804–1813.PubMed

Hatton, D. D., Wheeler, A. C., Skinner, M. L., Bailey, D. B., Sullivan, K. M., Roberts, J. E., et al. (2003). Adaptive behavior in children with fragile X syndrome. American Journal of Mental Retardation, 108, 373–390.PubMedCrossRef

Hegvik, R. L., McDevitt, S. C., & Carey, W. B. (1995). Middle childhood temperament questionnaire. Scottsdale, AZ: Behavioral-Developmental Initiatives.

Hessl, D., & Cohen, S. (2005). Social anxiety, stress, and autism in fragile X syndrome. In J. E. Roberts (Chair), Physiological correlates to behavior and cognition in neurodevelopmental disorders. Symposium conducted at the 38th Annual Gatlinburg Conference on Research and Theory in Intellectual and Developmental Disabilities, Annapolis, MD.

Hessl, D., Dyer-Friedman, J., Glaser, B., Wisbeck, J., Barajas, R. G., Taylor, A., et al. (2001). The influence of environmental and genetic factors on behavior problems and autistic symptoms in boys and girls with fragile X syndrome. Pediatrics, 108, e88.PubMedCrossRef

Jackson, C. T., Fein, D., Wolf, J., Jones, G., Hauck, M., Waterhouse, L., et al. (2003). Responses and sustained interactions in children with mental retardation and autism. Journal of Autism and Developmental Disorders, 33, 115–121.PubMedCrossRef

Kau, A. S. M., Tierney, E., Bukelis, I., Stump, M. H., Kates, W. R., Trescher, W. H., et al. (2004). Social behavior profile in young males with fragile X syndrome: Characteristics and specificity. American Journal of Medical Genetics, 126A, 9–17.CrossRef

Kaufmann, W. E., Abrams, M. T., Chen, W., & Reiss, A. L. (1999). Genotype, molecular phenotype, and cognitive phenotype: Correlations in fragile X syndrome. American Journal of Medical Genetics, 83, 286–295.PubMedCrossRef

Kaufmann, W. E., Cortell, R., Kau, A. S. M., Bukelis, I., Tierney, E., Gray, R. M., et al. (2004). Autism spectrum disorder in fragile X syndrome: Communication, social interaction, and specific behaviors. American Journal of Medical Genetics, 129A, 225–234.CrossRef

Locke, R. L, Christensen, M., Soleimani, C., Zugin, Z., Thurow, M., Mueller, C., et al. (2003). Associations between affective modulation of startle and fearful temperament. Poster session presented at the biennial meeting of the Society for Research in Child Development, Tampa, FL.

McDevitt, S. C., & Carey, W. B. (1995). Behavioral style questionnaire. Scottsdale, AZ: Behavioral-Developmental Initiatives.

Merenstein, S. A., Sobesky, W. E., Taylor, A. K., Riddle, J. E., Tran, H. X., & Hagerman, R. J. (1996). Molecular-clinical correlations in males with an expanded FMR1 mutation. American Journal of Medical Genetics, 64, 388–394.PubMedCrossRef

Miller, L. J., McIntosh, D. N., McGrath, J., Shyu, V., Lampe, M., Taylor, A. K., et al. (1999). Electrodermal responses to sensory. stimuli in individuals with fragile X syndrome: A preliminary report. American Journal of Medical Genetics, 83, 268–279.PubMedCrossRef

Mullen, E. M. (1995). Mullen scales of early learning. Circle Pines, MN: American Guidance Service.

Oberle, I., Rousseau, F., Heitz, D., Kretz, C., Devys, D., Hanauer, A., et al. (1991). Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome. Science, 252, 1097–1102.CrossRef

Roberts, J. E., Boccia, M. L., Bailey, D. B., Jr., Hatton, D. D., & Skinner, M. (2001). Cardiovascular indices of physiological arousal in boys with fragile X syndrome. Developmental Psychobiology, 39, 107–123.

Rogers, S. J., Hepburn, S. L., & Wehner, E. (2003). Parent reports of sensory symptoms in toddlers with autism and those with other developmental disorders. Journal of Autism and Developmental Disorders, 33, 631–642. PubMedCrossRef

Rogers, S. J., Hepburn, S. L., Stackhouse, T., & Wehner, E. (2003). Imitation performance in toddlers with autism and those with other developmental disorders. Journal of Child Psychology and Psychiatry, 44, 763–781. PubMedCrossRef

Rogers, S. J., Wehner, D. E., & Hagerman, R. (2001). The behavioral phenotype in fragile X: Symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders. Journal of Developmental and Behavioral Pediatrics, 22, 409–417.PubMed

Roid, G. H., & Miller, L. J. (1995, 1997). Leiter international performance scale—revised. Wood Dale, IL: Stoelting Co.

Scheffe, H. (1953). A method for judging all contrasts in the analysis of variance. Biometrika, 40, 87–104.

Schopler, E., Reichler, R. J., & Renner, B. R. (1988). The childhood autism rating scale (CARS). Los Angeles: Western Psychological Services.

Sherman, S. (2002). Epidemiology. In R. J. Hagerman P. J. Hagerman (Eds.), Fragile X syndrome: Diagnosis, treatment and research. Baltimore, MD: The Johns Hopkins University Press (pp. 136–168).

Sparrow, S. S., Balla, D. A., & Cicchetti, D. V. (1984). Vineland adaptive behavior scales. Circle Pines, MN: American Guidance Service.

Sullivan, K., Hatton, D., Hammer, J., Sideris, J., Hooper, S., Ornstein, P., et al. (2006). ADHD symptoms in children with FXS. American Journal of Medical Genetics, 140, 2275–2288.PubMed

Tassone, F., Hagerman, R. J., Taylor, A. K., Mills, J. B., Harris, S. W., Gane, L. W., et al. (2000). Clinical involvement and protein expression in individuals with the FMR1 premutation. American Journal of Medical Genetics, 91, 144–152.PubMedCrossRef

Weisenfield, L. A., & Roberts, J. E. (2005). Social approach and autism status among young males with fragile X syndrome. Poster presented at the 38th Annual Gatlinburg Conference on Research and Theory in Intellectual and Developmental Disabilities, Annapolis, MD.

Wolff, P. H., Gardner, J., Paccla, J., & Lappen, J. (1989). The greeting behavior of fragile X males. American Journal of Mental Retardation, 93, 406–411.PubMed

Titel: Social Approach and Autistic Behavior in Children with Fragile X Syndrome
Auteurs: Jane E. Roberts
Leigh Anne H. Weisenfeld
Deborah D. Hatton
Morgan Heath
Walter E. Kaufmann
Publicatiedatum: 01-10-2007
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 9/2007
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-006-0305-9

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