Introduction
Methods
Sample
Study design
Measures
Generic-HRQOL measure
PD-targeted HRQOL measures
Criterion variables for evaluating validity of HRQOL measures
Data collection
Data analysis
Total | Patients with follow-up data | Patients without follow-up dataa
|
P-value | |
---|---|---|---|---|
N (%) Mean (SD)
N = 96 |
N (%) Mean (SD)
N = 58 |
N (%) Mean (SD)
N = 38 | ||
Male | 81 (84.4) | 46 (79.3) | 35 (92.1) | 0.09 |
Age | 71.6 (10.9) | 70.9 (10.2) | 72.6 (11.9) | 0.44 |
Race | ||||
White | 84 (87.5) | 53 (91.4) | 31 (81.6) | 0.03 |
Black | 3 (3.1) | 3 (5.2) | 0 (0.0) | |
Hispanic | 7 (7.3) | 1 (1.7) | 6 (15.8) | |
Asian | 1 (1.0) | 0 (0.0) | 1 (2.6) | |
Other | 1 (1.0) | 1 (1.7) | 0 (0.0) | |
Marital status | ||||
Married | 62 (64.6) | 35 (60.3) | 27 (71.1) | 0.34 |
Separated | 2 (2.1) | 1 (1.7) | 1 (2.6) | |
Divorced | 18 (18.8) | 14 (21.1) | 4 (10.5) | |
Widowed | 9 (9.4) | 4 (6.9) | 5 (13.2) | |
Never married | 5 (5.2) | 4 (6.9) | 1 (2.6) | |
Highest degree | ||||
None/less than high school | 3 (3.1) | 2 (3.5) | 1 (2.6) | 0.78 |
High school or GED | 22 (22.9) | 11 (19.0) | 11 (29.0) | |
Associate’s degree | 11 (11.5) | 8 (13.8) | 3 (8.0) | |
Bachelor’s degree | 38 (39.6) | 23 (39.7) | 15 (39.5) | |
Graduate/professional degree | 22 (22.9) | 14 (24.1) | 8 (21.1) | |
Years of schooling | 15.7 (2.4) | 15.7 (2.5) | 15.5 (2.3) | 0.68 |
Employment | ||||
Working full time/part time | 18 (18.8) | 6 (10.3) | 12 (31.6) | 0.06 |
With a job and not working for other reasons | 1 (1.0) | 1 (1.7) | 0 (0.0) | |
Unemployed and looking for work | 1 (1.0) | 0 (0.0) | 1 (2.6) | |
Disabled and not working | 13 (13.5) | 9 (15.5) | 4 (10.5) | |
Retired and not working | 63 (65.6) | 42 (72.4) | 21 (55.3) | |
UPDRS ADLs scale | ||||
(Range: 0–48) 0 = best state | 14.5 (7.6) | 14.2 (7.8) | 15.1 (7.3) | 0.54 |
Recruited at VA | 54 (56.2) | 32 (55.2) | 22 (57.9) | 0.79 |
How Parkinson’s disease affects you on a day-to-day basis? | ||||
No difficulties | 10 (10.4) | 8 (13.8) | 2 (5.3) | 0.17 |
Mild difficulties | 34 (35.4) | 23 (39.7) | 11 (28.9) | |
Moderate difficulties | 38 (39.6) | 17 (29.3) | 21 (55.3) | |
High levels of difficulties | 12 (12.5) | 10 (17.2) | 2 (5.3) | |
Extreme difficulties | 2 (2.1) | 0 (0.0) | 2 (5.3) | |
On a scale of 1–10, where 10 is the best possible quality of life and 1 is the worst possible quality of life (as bad or worse than being dead) overall, how would you rate your quality of life? | ||||
1 | 1 (1.0) | 1 (1.7) | 0 (0.0) | 0.33 |
2 | 1 (1.0) | 0 (0.0) | 1 (2.6) | |
3 | 4 (4.2) | 1 (1.7) | 3 (7.9) | |
4 | 5 (5.2) | 3 (5.2) | 2 (5.3) | |
5 | 15 (15.6) | 11 (19.0) | 4 (10.5) | |
6 | 11 (11.5) | 5 (8.6) | 6 (15.8) | |
7 | 31 (32.3) | 18 (31.0) | 13 (34.2) | |
8 | 21 (21.9) | 13 (22.4) | 8 (21.1) | |
9 | 6 (6.3) | 5 (8.6) | 1 (2.6) | |
10 | 1 (1.0) | 1 (1.7) | 0 (0.0) |
Results
Sample characteristics
Descriptive statistics and reliability
Baseline | Number of items | Mean | SD | Percent scoring minimum (= 0)/maximum (= 100) | Cronbach’s alpha |
---|---|---|---|---|---|
SF-36 v. 1.0 (range: 0–100, where 100 is best quality of life) | |||||
Physical Function | 10 | 58.0 | 30.8 | 4.2/3.1 | 0.94 |
Role Limitations—Physical | 4 | 28.4 | 35.3 | 51.0/10.4 | 0.81 |
Role Limitations—Emotional | 3 | 76.4 | 41.9 | 21.9/75.0 | 0.98 |
Pain | 2 | 63.2 | 26.5 | 0.0/15.6 | 0.85 |
Emotional Well-Being | 5 | 69.7 | 18.1 | 1.0/0.0 | 0.86 |
Energy | 4 | 47.0 | 22.8 | 3.1/0.0 | 0.92 |
General Health | 5 | 52.4 | 22.0 | 2.1/1.0 | 0.76 |
Social Function | 2 | 61.0 | 33.3 | 6.3/29.2 | 0.98 |
SF-36 composite scores (T-scores) | |||||
Physical Health (PCS) | – | 36.0 | 10.5 | n/a | 0.93b
|
Mental Health (MCS) | – | 49.1 | 12.0 | n/a | 0.97b
|
PDQUALIF (range: 0–100, where 100 is best quality of life) | |||||
Social/Role Function | 9 | 52.6 | 26.0 | 1.0/1.0 | 0.88 |
Self-Image and Sexuality | 7 | 60.3 | 23.4 | 0.0/4.2 | 0.80 |
Sleep | 3 | 64.6 | 28.3 | 2.1/21.1 | 0.60 |
Outlook | 4 | 61.1 | 21.3 | 0.0/3.2 | 0.55 |
Physical Function | 5 | 70.9 | 17.4 | 0.0/2.1 | 0.52 |
Independence | 2 | 79.2 | 32.9 | 11.6/60.0 | 0.89 |
Urinary Function | 2 | 39.3 | 35.4 | 27.4/10.5 | 0.85 |
Total score | – | 61.2 | 18.4 | – | 0.93b
|
PDQ-39 (range: 0–100, where 100 is best quality of life) | |||||
Mobility | 10 | 62.2 | 29.3 | 2.1/5.2 | 0.93 |
Activities of Daily Living | 6 | 65.3 | 25.0 | 2.1/5.2 | 0.89 |
Emotional Well-Being | 6 | 74.3 | 21.5 | 1.0/9.4 | 0.86 |
Stigma | 4 | 74.6 | 28.2 | 1.0/34.4 | 0.88 |
Social Support | 3 | 83.2 | 25.9 | 2.1/54.2 | 0.85 |
Cognitions | 4 | 73.4 | 20.4 | 1.0/10.4 | 0.68 |
Communication | 3 | 75.8 | 23.4 | 1.0/29.2 | 0.75 |
Bodily Discomfort | 3 | 62.2 | 22.7 | 1.0/7.3 | 0.59 |
Total score | – | 71.4 | 18.0 | – | 0.96b
|
Relative validity
Criterion variable #1: how PD affects you on a day-to-day basis
How Parkinson’s disease affects you on a day-to-day basis? | ||||||
---|---|---|---|---|---|---|
Scale | No difficulties (n = 10) | Mild difficulties (n = 34) | Moderate difficulties (n = 38) | High levels of or extreme difficulties (n = 14) |
F-ratiob
| Relative validityc
|
SF-36 v. 1.0 (range: 0–100, where 100 is best quality of life) | ||||||
Physical Function | 88.5d
| 71.6d
| 48.2e
| 29.6f
| 15.72 | 6.72 |
Role Limitations—Physical | 67.5d
| 41.9e
| 16.5f
| 0.0f
| 14.64 | 6.26 |
Role Limitations—Emotional | 90.0d
| 88.2d
| 7.6d
| 42.9e
| 4.79 | 2.05 |
Pain | 77.5d
| 64.9d
| 67.5d
| 37.1e
| 6.97 | 2.98 |
Emotional Well-Being | 76.4d
| 76.9d
| 67.6d
| 53.1e
| 7.66 | 3.27 |
Energy | 69.5d
| 56.0e
| 39.2f
| 30.4f
| 12.14 | 5.19 |
General Health | 64.5d
| 57.9d,e
| 47.9e,f
| 42.5f
| 3.44 | 1.47 |
Social Function | 88.8d
| 79.4d
| 49.7e
| 26.8f
| 19.13 | 8.18 |
SF-36 composite scores (T-scores) | ||||||
Physical Health (PCS) | 47.7d
| 39.2e
| 33.2e
| 27.1f
| 12.86 | 5.50 |
Mental Health (MCS) | 53.4d
| 53.4d
| 47.3d
| 39.2e
| 6.68 | 2.85 |
PDQUALIF (range: 0–100, where 100 is best quality of life) | ||||||
Social/Role Function | 80.8d
| 67.5e
| 42.5f
| 21.4g
| 31.07 | 13.28 |
Self-Image and Sexuality | 82.1d
| 71.1d
| 53.3e
| 35.9f
| 16.71 | 7.14 |
Sleep | 85.0d
| 70.6d,e
| 57.2e
| 54.5e
| 4.00 | 1.71 |
Outlook | 75.0d
| 71.9d
| 53.3e
| 44.7e
| 11.44 | 4.89 |
Physical Function | 83.5d
| 75.3d,e
| 69.7e
| 53.5f
| 8.49 | 3.63 |
Independence | 100.0d
| 87.7d
| 79.9d
| 38.5e
| 11.84 | 5.06 |
Urinary Function | 55.0d
| 47.1d,e
| 29.3e
| 36.5d,e
| 2.34c
| 1.00 |
Total score | 80.2d
| 70.2e
| 55.0f
| 40.7g
| 21.64 | 9.25 |
PDQ-39 (range: 0–100, where 100 is best quality of life) | ||||||
Mobility | 94.0d
| 77.8e
| 52.4f
| 28.0g
| 27.4 | 11.71 |
Activities of Daily Living | 88.8d
| 75.1d
| 60.2e
| 38.4f
| 15.43 | 6.59 |
Emotional Well-Being | 85.4d
| 85.2d
| 67.3e
| 58.6e
| 9.63 | 4.12 |
Stigma | 81.9d
| 86.0d
| 72.2d
| 48.2e
| 7.57 | 3.24 |
Social Support | 91.7d
| 93.6d
| 79.6d
| 61.9e
| 6.58 | 2.81 |
Cognitions | 81.3d
| 80.3d
| 69.6d, e
| 61.2e
| 4.34 | 1.85 |
Communication | 91.2d
| 86.6d
| 68.4e
| 56.6e
| 11.95 | 5.11 |
Bodily Discomfort | 74.2d
| 69.4d
| 59.4d
| 43.5e
| 6.33 | 2.71 |
Total score | 86.4d
| 81.8d
| 66.2e
| 49.5e
| 24.8 | 10.60 |
Criterion variable #2: rating of overall QOL
Scale | On a scale of 1–10, where 10 is best possible quality of life and 1 is the worst possible quality of life (as bad or worse than being dead) overall, how would you rate your quality of life? | ||||
---|---|---|---|---|---|
Values 8–10 (n = 28) | Values 6–7 (n = 42) | Values 1–5 (n = 26) |
F-ratiob
| Relative validityc
| |
SF-36 v. 1.0 (range: 0–100, where 100 is best quality of life) | |||||
Physical Function | 71.8d
| 58.2d
| 42.7e
| 6.74 | 3.46 |
Role Limitations—Physical | 50.9d
| 26.8e
| 6.7f
| 13.42 | 6.88 |
Role Limitations—Emotional | 100.0d
| 83.3d
| 39.7e
| 21.45 | 11.00 |
Pain | 73.6d
| 63.5d,e
| 51.5e
| 5.06 | 2.59 |
Emotional Well-Being | 80.7d
| 73.4e
| 51.9f
| 30.10 | 15.44 |
Energy | 62.9d
| 45.1e
| 33.1f
| 15.29 | 7.84 |
General Health | 65.4d
| 52.9e
| 37.7f
| 13.42 | 6.88 |
Social Function | 82.1d
| 62.5e
| 35.6f
| 18.00 | 9.23 |
SF-36 composite scores (T-scores) | |||||
Physical Health (PCS) | 41.3d
| 35.0e
| 31.8e
| 6.47 | 3.32 |
Mental Health (MCS) | 56.7d
| 51.0e
| 37.7f
| 28.05 | 14.38 |
PDQUALIF (range: 0–100, where 100 is best quality of life) | |||||
Social/Role Function | 67.8d
| 52.8e
| 35.2f
| 13.04 | 6.69 |
Self-Image and Sexuality | 74.6d
| 59.6e
| 45.6f
| 12.75 | 6.54 |
Sleep | 76.2d
| 64.9e
| 51.0e
| 5.77 | 2.96 |
Outlook | 72.3d
| 64.1d
| 43.3e
| 17.73 | 9.09 |
Physical Function | 80.4d
| 68.7e
| 64.2e
| 7.13 | 3.66 |
Independence | 86.6d
| 80.4d,e
| 69.0e
| 1.95c
| 1.00 |
Urinary Function | 53.1d
| 32.1e
| 36.0e
| 3.26 | 1.67 |
Total score | 73.0d
| 60.4e
| 49.2f
| 14.28 | 7.32 |
PDQ-39 (range: 0–100, where 100 is best quality of life) | |||||
Mobility | 77.1d
| 63.2e
| 44.6f
| 9.93 | 5.09 |
Activities of Daily Living | 75.9d
| 65.6e
| 53.4f
| 6.05 | 3.10 |
Emotional Well-Being | 85.9d
| 77.9e
| 55.9f
| 19.56 | 10.03 |
Stigma | 86.4d
| 77.1e
| 57.9f
| 8.25 | 4.23 |
Social Support | 96.7d
| 86.3d
| 63.8e
| 14.75 | 7.56 |
Cognitions | 80.1d
| 71.4d,e
| 69.2e
| 2.33 | 1.19 |
Communication | 88.5d
| 75.0e
| 63.5f
| 9.09 | 4.66 |
Bodily Discomfort | 73.2d
| 59.9e
| 53.9e
| 5.79 | 2.97 |
Total score | 82.9d
| 72.0e
| 57.8f
| 18.29 | 9.38 |
Responsiveness of HRQOL measures
Baseline mean in declined group (SD) | Average change in declined group (SD) | Average change in the unchanged group (SD) | Effect size statistic | SRM | Guyatt |
F (P value) | |
---|---|---|---|---|---|---|---|
SF-36 v. 1.0 (range: 0–100, where 100 is best quality of life) | |||||||
Physical Function | 70.0 (26.7) | −22.8 (22.0) | −1.6 (22.9) | −0.85b
| −1.04 | −0.99 | 9.54 (0.004) |
Role Limitations—Physical | 47.5 (41.3) | −16.3 (43.9) | 6.9 (29.4) | −0.39d
| −0.37 | −0.55 | 4.22 (0.05) |
Role Limitations—Emotional | 90.0 (30.8) | −11.7 (49.9) | −2.9 (43.7) | −0.38d
| −0.23 | −0.27 | 0.38 (0.54) |
Pain | 68.4 (24.5) | −1.5 (30.0) | 2.2 (26.5) | −0.06 | −0.05 | −0.06 | 0.18 (0.67) |
Emotional Well-Being | 77.8 (13.8) | −1.2 (19.0) | −3.0 (18.9) | −0.09 | −0.06 | −0.06 | 0.09 (0.76) |
Energy | 66.3 (17.2) | −19.5 (22.3) | −3.0 (23.7) | −1.13b
| −0.87 | −0.82 | 5.44 (0.03) |
General Health | 69.8 (10.4) | −18.0 (17.7) | −4.1 (13.8) | −1.72b
| −1.02 | −1.31 | 8.31 (0.006) |
Social Function | 81.9 (24.5) | −12.5 (39.5) | 1.1 (28.2) | −0.51c
| −0.32 | −0.44 | 1.72 (0.20) |
SF-36 composite scores (T-scores) | |||||||
Physical Health (PCS) | 41.3 (8.9) | −7.7 (10.1) | 0.8 (6.9) | −0.86b
| −0.76 | −1.11 | 10.51 (0.002) |
Mental Health (MCS) | 55.5 (8.5) | −2.5 (10.7) | −1.6 (10.8) | −0.29d
| −0.23 | −0.22 | 0.08 (0.78) |
PDQUALIF (range: 0–100, where 100 is best quality of life) | |||||||
Social/Role Function | 69.4 (23.9) | −19.1 (21.7) | −1.7 (21.1) | −0.80b
| −0.88 | −0.91 | 6.98 (0.01) |
Self-Image and Sexuality | 69.5 (22.9) | −5.9 (19.6) | 7.8 (19.3) | −0.26d
| −0.30 | −0.31 | 5.18 (0.03) |
Sleep | 72.5 (29.0) | −10.0 (23.8) | −12.8 (28.9) | −0.35d
| −0.42 | −0.35 | 0.12 (0.73) |
Outlook | 74.7 (18.3) | −3.8 (18.5) | 1.4 (19.1) | −0.21d
| −0.21 | −0.20 | 0.79 (0.38) |
Physical Function | 73.0 (19.9) | −3.3 (19.7) | −11.1 (13.5) | −0.16 | −0.17 | −0.24 | 2.32 (0.14) |
Independence | 84.4 (31.9) | −20.6 (34.5) | −1.14 (32.0) | −0.65c
| −0.60 | −0.64 | 3.61 (0.07) |
Urinary Function | 43.1 (31.0) | 2.5 (36.9) | 0.6 (44.4) | −0.08 | 0.07 | 0.06 | 0.02 (0.88) |
Total score | 69.5 (17.2) | −8.6 (15.2) | −2.4 (17.7) | −0.50c
| −0.57 | −0.49 | 1.44 (0.24) |
PDQ-39 (range: 0–100, where 100 is best quality of life) | |||||||
Mobility | 75.4 (26.4) | −16.9 (26.1) | 5.4 (16.2) | −0.64c
| −0.65 | −1.04 | 11.62 (0.002) |
Activities of Daily Living | 68.3 (27.5) | −13.5 (27.1) | 2.0 (15.1) | −0.49d
| −0.50 | −0.89 | 5.59 (0.02) |
Emotional Well-Being | 85.0 (20.9) | −7.1 (14.3) | −1.5 (15.2) | −0.34d
| −0.49 | −0.47 | 1.51 (0.23) |
Stigma | 80.9 (27.8) | 4.7 (22.2) | 10.9 (21.1) | 0.17 | 0.21 | 0.22 | 0.88 (0.35) |
Social Support | 88.3 (27.1) | 0.4 (34.0) | 2.7 (18.2) | 0.02 | 0.01 | 0.02 | 0.08 (0.78) |
Cognitions | 74.1 (17.4) | −7.2 (21.8) | −1.4 (12.9) | −0.41d
| −0.33 | −0.56 | 1.18 (0.29) |
Communication | 83.1 (23.5) | −14.2 (16.2) | 2.2 (21.4) | −0.60c
| −0.88 | −0.66 | 7.8 (0.008) |
Bodily Discomfort | 63.8 (25.6) | −7.5 (23.6) | 2.5 (20.6) | −0.29d
| −0.32 | −0.36 | 2.22 (0.14) |
Total score | 77.4 (19.7) | −7.7 (15.9) | 2.9 (11.1) | −0.39d
| −0.48 | −0.69 | 6.44 (0.02) |
Baseline mean in declined group (SD) | Average change in declined group (SD) | Average change in the unchanged group (SD) | Effect size statistic | SRM | Guyatt |
F (P value) | |
---|---|---|---|---|---|---|---|
SF-36 v. 1.0 (range: 0–100, where 100 is best quality of life) | |||||||
Physical Function | 59.1 (29.2) | −12.6 (23.9) | −7.0 (24.3) | −0.43d
| −0.53 | −0.52 | 0.58 (0.45) |
Role Limitations—Physical | 50.0 (44.7) | −15.6 (49.1) | 4.5 (33.5) | −0.35d
| −0.31 | −0.47 | 2.94 (0.09) |
Role Limitations—Emotional | 93.8 (25.0) | −12.5 (29.5) | −7.6 (51.2) | −0.50c
| −0.42 | −0.24 | 0.13 (0.72) |
Pain | 69.8 (23.3) | −9.5 (32.8) | 8.9 (29.7) | −0.40d
| −0.29 | −0.32 | 3.95 (0.05) |
Emotional Well-Being | 80.5 (7.4) | −6.0 (19.3) | 0.9 (16.4) | −0.81b
| −0.31 | −0.37 | 1.75 (0.19) |
Energy | 60.6 (20.4) | −17.2 (24.2) | −4.7 (24.7) | −0.84b
| −0.71 | −0.70 | 2.84 (0.10) |
General Health | 66.9 (12.8) | −15.9 (14.4) | −4.7 (18.9) | −1.24b
| −1.10 | −0.84 | 4.46 (0.04) |
Social Function | 83.6 (26.9) | −19.5 (39.0) | 6.4 (32.8) | −0.72c
| −0.50 | −0.59 | 6.10 (0.02) |
SF-36 composite scores (T-scores) | |||||||
Physical Health (PCS) | 38.7 (9.8) | −5.7 (10.8) | −0.1 (9.5) | −0.58c
| −0.52 | −0.60 | 3.52 (0.07) |
Mental Health (MCS) | 57.3 (5.0) | −5.3 (10.9) | −0.3 (10.5) | −1.06b
| −0.49 | −0.50 | 2.44 (0.13) |
PDQUALIF (range: 0–100, where 100 is best quality of life) | |||||||
Social/Role Function | 67.2 (26.4) | −18.4 (22.7) | −1.6 (21.6) | −0.70c
| −0.81 | −0.85 | 6.43 (0.02) |
Self-Image and Sexuality | 62.1 (25.4) | −6.9 (19.0) | 4.3 (19.1) | −0.27d
| −0.36 | −0.39 | 3.78 (0.06) |
Sleep | 71.4 (30.3) | −16.9 (25.9) | −10.4 (27.9) | −0.56c
| −0.65 | −0.61 | 0.63 (0.43) |
Outlook | 66.8 (19.9) | 0.8 (11.8) | 2.5 (10.1) | 0.04 | 0.07 | 0.08 | 0.10 (0.75) |
Physical Function | 71.6 (21.7) | −4.4 (17.5) | −4.9 (16.6) | −0.20d
| −0.25 | −0.27 | 0.01 (0.93) |
Independence | 84.4 (34.3) | −18.0 (36.2) | 6.4 (37.9) | −0.52c
| −0.50 | −0.48 | 4.67 (0.04) |
Urinary Function | 43.0 (32.6) | −5.5 (35.4) | 1.1 (42.0) | −0.17 | −0.16 | −0.13 | 0.29 (0.59) |
Total score | 66.6 (17.6) | −9.9 (13.5) | −0.4 (17.2) | −0.56c
| −0.73 | −0.58 | 3.83 (0.06) |
PDQ-39 (range: 0–100, where 100 is best quality of life) | |||||||
Mobility | 68.9 (27.4) | −13.7 (26.1) | 4.7 (22.8) | −0.50c
| −0.52 | −0.60 | 6.59 (0.01) |
Activities of Daily Living | 64.8 (27.0) | −10.7 (20.5) | 1.8 (26.4) | −0.40d
| −0.52 | −0.41 | 2.80 (0.10) |
Emotional Well-Being | 83.9 (18.3) | −4.9 (8.8) | −3.0 (17.1) | −0.27d
| −0.56 | −0.29 | 0.18 (0.67) |
Stigma | 77.7 (24.4) | 4.3 (18.9) | 13.2 (21.5) | 0.18 | 0.23 | 0.20 | 2.03 (0.16) |
Social Support | 85.9 (28.5) | −2.1 (20.9) | −0.1 (23.5) | −0.07 | −0.10 | −0.09 | 0.08 (0.78) |
Cognitions | 75.4 (16.5) | −3.9 (22.6) | −2.1 (13.3) | −0.24d
| −0.17 | −0.29 | 0.12 (0.73) |
Communication | 77.9 (23.2) | −4.2 (17.7) | −5.7 (20.1) | −0.18 | −0.23 | −0.20 | 0.07 (0.79) |
Bodily Discomfort | 64.6 (24.2) | −2.1 (18.6) | 1.7 (20.9) | −0.09 | −0.11 | −0.10 | 0.38 (0.54) |
Total score | 74.9 (16.4) | −4.7 (11.5) | 1.3 (13.3) | −0.29d
| −0.41 | −0.35 | 2.38 (0.13) |