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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2015

01-02-2015 | Original Paper

Sex Differences in Social Perception in Children with ASD

Auteurs: M. C. Coffman, L. C. Anderson, A. J. Naples, J. C. McPartland

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2015

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Abstract

Autism spectrum disorder (ASD) is more common in males than females. An underrepresentation of females in the ASD literature has led to limited knowledge of differences in social function across the sexes. Investigations of face perception represent a promising target for understanding variability in social functioning between males and females. The current study analyzed electrophysiological brain recordings during face perception to investigate sex differences in the neural correlates of face perception and their relationship to social function. Event related potentials (ERP) were recorded from children with ASD while viewing faces, inverted faces, and houses. Relative to males, females showed attenuated response at an ERP marker of face perception, the N170. Among females, but not males, atypical face response was associated with symptom severity. Observed sex differences reflect influential differences in social information processing, and impairment in these features correlates with deficits in social information processing in females, but not males, with ASD. These findings hold significance for future treatment protocols, which should account for differences in males and females with ASD in clinical presentation and neural phenotypes.
Literatuur
go back to reference American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR (4th ed.). Washington, DC: American Psychiatric Association. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR (4th ed.). Washington, DC: American Psychiatric Association.
go back to reference Baio, J. (2012). Prevalence of autism spectrum disorders: Autism and developmental disabilities monitoring network, 14 Sites, United States, 2008. Morbidity and mortality weekly report. Surveillance Summaries, 61(3), 0738–1546. Baio, J. (2012). Prevalence of autism spectrum disorders: Autism and developmental disabilities monitoring network, 14 Sites, United States, 2008. Morbidity and mortality weekly report. Surveillance Summaries, 61(3), 0738–1546.
go back to reference Bauer, D., Goldfield, B., & Reznick, S. (2002). Alternative approaches to analyzing individual differences in the rate of early vocabulary development. Applied Psycholinguistics, 23(3), 313–335.CrossRef Bauer, D., Goldfield, B., & Reznick, S. (2002). Alternative approaches to analyzing individual differences in the rate of early vocabulary development. Applied Psycholinguistics, 23(3), 313–335.CrossRef
go back to reference Bentin, S., Allison, T., Puce, A., Perez, E., & McCarthy, G. (1996). Electrophysiological studies of face perception in humans. Journal of Cognitive Neuroscience, 8(6), 551–565.PubMedCentralPubMedCrossRef Bentin, S., Allison, T., Puce, A., Perez, E., & McCarthy, G. (1996). Electrophysiological studies of face perception in humans. Journal of Cognitive Neuroscience, 8(6), 551–565.PubMedCentralPubMedCrossRef
go back to reference Benton, A., Sivan, A., Hamsher, K., Varney, N., & Spreen, O. (1994). Contributions to neuropsychological assessment. New York: Oxford University Press. Benton, A., Sivan, A., Hamsher, K., Varney, N., & Spreen, O. (1994). Contributions to neuropsychological assessment. New York: Oxford University Press.
go back to reference Bryson, S., & Smith, I. (1998). Epidemiology of autism: Prevalence, associated characteristics, and implications for research and service delivery. Mental Retardation and Developmental Disabilities Research Reviews, 4(2), 97–103.CrossRef Bryson, S., & Smith, I. (1998). Epidemiology of autism: Prevalence, associated characteristics, and implications for research and service delivery. Mental Retardation and Developmental Disabilities Research Reviews, 4(2), 97–103.CrossRef
go back to reference Carter, A., Black, D., Tewani, S., Connolly, C., Kadlec, M., & Tager-Flusberg, H. (2007). Sex differences in toddlers with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37, 86–97.PubMedCrossRef Carter, A., Black, D., Tewani, S., Connolly, C., Kadlec, M., & Tager-Flusberg, H. (2007). Sex differences in toddlers with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37, 86–97.PubMedCrossRef
go back to reference Eisenberg, N., & Lennon, R. (1983). Sex differences in empathy and related capacities. Psychological Bulletin, 94(1), 100–131.CrossRef Eisenberg, N., & Lennon, R. (1983). Sex differences in empathy and related capacities. Psychological Bulletin, 94(1), 100–131.CrossRef
go back to reference Elliott, C. D. (2007). Differential Ability Scales: Second edition (DAS-II). San Antonio, TX: Psychological Corporation. Elliott, C. D. (2007). Differential Ability Scales: Second edition (DAS-II). San Antonio, TX: Psychological Corporation.
go back to reference Elsabbagh, M., Mercure, E., Hudry, K., Chandler, S., Pasco, G., Charman, T., et al. (2012). Infant neural sensitivity to dynamic eye gaze is associated with later emerging autism. Current Biology, 22(4), 338–342.PubMedCentralPubMedCrossRef Elsabbagh, M., Mercure, E., Hudry, K., Chandler, S., Pasco, G., Charman, T., et al. (2012). Infant neural sensitivity to dynamic eye gaze is associated with later emerging autism. Current Biology, 22(4), 338–342.PubMedCentralPubMedCrossRef
go back to reference Fombonne, E. (2003). Epidemiological surveys of autism and other pervasive developmental disorders: An update. Journal of Autism and Developmental Disorders, 33(4), 365–382.PubMedCrossRef Fombonne, E. (2003). Epidemiological surveys of autism and other pervasive developmental disorders: An update. Journal of Autism and Developmental Disorders, 33(4), 365–382.PubMedCrossRef
go back to reference Gadow, K., & Sprafkin, J. (1994). Child symptom inventories manual. Stony Brook, NY: Checkmate Plus. Gadow, K., & Sprafkin, J. (1994). Child symptom inventories manual. Stony Brook, NY: Checkmate Plus.
go back to reference Happé, F. (1995). The role of age and verbal ability in the theory of mind task performance of subjects with autism. Society for Research in Child Development, 66, 843–855.CrossRef Happé, F. (1995). The role of age and verbal ability in the theory of mind task performance of subjects with autism. Society for Research in Child Development, 66, 843–855.CrossRef
go back to reference Hartley, S., & Sikora, D. (2009). Sex differences in autism spectrum disorder: An examination of developmental functioning, autistic symptoms, and coexisting behavior problems in toddlers. Journal of Autism and Developmental Disorders, 39, 1715–1722.PubMedCentralPubMedCrossRef Hartley, S., & Sikora, D. (2009). Sex differences in autism spectrum disorder: An examination of developmental functioning, autistic symptoms, and coexisting behavior problems in toddlers. Journal of Autism and Developmental Disorders, 39, 1715–1722.PubMedCentralPubMedCrossRef
go back to reference Herlitz, A., & Rehnman, J. (2008). Sex differences in episodic memory. Current Directions in Psychological Science, 17(1), 52–56.CrossRef Herlitz, A., & Rehnman, J. (2008). Sex differences in episodic memory. Current Directions in Psychological Science, 17(1), 52–56.CrossRef
go back to reference Holtmann, M., Bolte, S., & Poustka, F. (2007). Autism spectrum disorders: Sex differences in autistic behaviour domains and coexisting psychopathology. Developmental Medicine and Child Neurology, 49, 361–366.PubMedCrossRef Holtmann, M., Bolte, S., & Poustka, F. (2007). Autism spectrum disorders: Sex differences in autistic behaviour domains and coexisting psychopathology. Developmental Medicine and Child Neurology, 49, 361–366.PubMedCrossRef
go back to reference Huttenlocher, J., Haight, W., Bryk, A., Seltzer, M., & Lyons, T. (1991). Early vocabulary growth: Relation to language input and gender. Developmental Psychology, 27(2), 236–248.CrossRef Huttenlocher, J., Haight, W., Bryk, A., Seltzer, M., & Lyons, T. (1991). Early vocabulary growth: Relation to language input and gender. Developmental Psychology, 27(2), 236–248.CrossRef
go back to reference Itier, R. J., & Taylor, M. J. (2002). Inversion and contrast polarity reversal affect both encoding and recognition processes of unfamiliar faces: A repetition study using ERPs. Neuroimage, 15(2), 353–372.PubMedCrossRef Itier, R. J., & Taylor, M. J. (2002). Inversion and contrast polarity reversal affect both encoding and recognition processes of unfamiliar faces: A repetition study using ERPs. Neuroimage, 15(2), 353–372.PubMedCrossRef
go back to reference Joliffe, T., & Baron-Cohen, S. (1997). Are people with autism and Asperger syndrome faster than normal on the embedded figures test? Journal of Child Psychology and Psychiatry, 38(5), 527–534.CrossRef Joliffe, T., & Baron-Cohen, S. (1997). Are people with autism and Asperger syndrome faster than normal on the embedded figures test? Journal of Child Psychology and Psychiatry, 38(5), 527–534.CrossRef
go back to reference Kansaku, K., Yamaura, A., & Kitazawa, S. (2000). Sex differences in lateralization revealed in the posterior language areas. Cerebral Cortex, 10, 866–872.PubMedCrossRef Kansaku, K., Yamaura, A., & Kitazawa, S. (2000). Sex differences in lateralization revealed in the posterior language areas. Cerebral Cortex, 10, 866–872.PubMedCrossRef
go back to reference Kanwisher, N., McDermott, J., & Chun, M. M. (1997). The fusiform face area: A module in human extrastriate cortex specialized for face perception. Journal of Neuroscience, 17(11), 4302–4311.PubMed Kanwisher, N., McDermott, J., & Chun, M. M. (1997). The fusiform face area: A module in human extrastriate cortex specialized for face perception. Journal of Neuroscience, 17(11), 4302–4311.PubMed
go back to reference Key, A., & Stone, W. (2012). Same but different: 9-month-old infants at average and high risk for autism look at the same facial features but process them using different brain mechanisms. Autism Research, 5(4), 253–266.PubMedCentralPubMedCrossRef Key, A., & Stone, W. (2012). Same but different: 9-month-old infants at average and high risk for autism look at the same facial features but process them using different brain mechanisms. Autism Research, 5(4), 253–266.PubMedCentralPubMedCrossRef
go back to reference Koenig, K., & Tsatanis, K. (2005). Pervasive developmental disorders in girls. In D. Bell, E. Foster, & E. Mash (Eds.), Behavioral and emotional problems in girls. New York: Kluwer Academic/Plenum Publishers. Koenig, K., & Tsatanis, K. (2005). Pervasive developmental disorders in girls. In D. Bell, E. Foster, & E. Mash (Eds.), Behavioral and emotional problems in girls. New York: Kluwer Academic/Plenum Publishers.
go back to reference Lai, M., Lombardo, M., Pasco, G., Ruigrok, A., Wheelwright, S., Sadek, S., et al. (2011). A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS ONE, 6, e20835.PubMedCentralPubMedCrossRef Lai, M., Lombardo, M., Pasco, G., Ruigrok, A., Wheelwright, S., Sadek, S., et al. (2011). A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS ONE, 6, e20835.PubMedCentralPubMedCrossRef
go back to reference Lang-Takac, E., & Osterweil, Z. (1992). Separateness and connectedness: Differences between the genders. Sex Roles, 27(5/6), 277–289.CrossRef Lang-Takac, E., & Osterweil, Z. (1992). Separateness and connectedness: Differences between the genders. Sex Roles, 27(5/6), 277–289.CrossRef
go back to reference Leeb, R., & Rejskind, G. (2004). Here’s looking at you, kid! A longitudinal study of perceived gender differences in mutual gaze behavior in young infants. Sex Roles, 50(1/2), 1–14.CrossRef Leeb, R., & Rejskind, G. (2004). Here’s looking at you, kid! A longitudinal study of perceived gender differences in mutual gaze behavior in young infants. Sex Roles, 50(1/2), 1–14.CrossRef
go back to reference Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.PubMedCrossRef Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.PubMedCrossRef
go back to reference Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.PubMedCrossRef Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.PubMedCrossRef
go back to reference Lord, C., & Schopler, E. (1985). Brief report: Differences in sex ratios in autism as a function of measured intelligence. Journal of Autism and Developmental Disorders, 15(2), 185–193.PubMedCrossRef Lord, C., & Schopler, E. (1985). Brief report: Differences in sex ratios in autism as a function of measured intelligence. Journal of Autism and Developmental Disorders, 15(2), 185–193.PubMedCrossRef
go back to reference Lord, C., Schopler, E., & Revicki, D. (1982). Sex differences in autism. Journal of Autism and Developmental Disorders, 12(4), 317–330.PubMedCrossRef Lord, C., Schopler, E., & Revicki, D. (1982). Sex differences in autism. Journal of Autism and Developmental Disorders, 12(4), 317–330.PubMedCrossRef
go back to reference Lutchmaya, S., & Baron-Cohen, S. (2002). Human sex differences in social and non-social looking preferences, at 12 months of age. Infant Behavior and Development, 25, 319–325.CrossRef Lutchmaya, S., & Baron-Cohen, S. (2002). Human sex differences in social and non-social looking preferences, at 12 months of age. Infant Behavior and Development, 25, 319–325.CrossRef
go back to reference Mandy, W., Chilvers, R., Chowdhury, U., Salter, G., Seigal, A., & Skuse, D. (2011). Sex differences in autism spectrum disorder: Evidence from a large sample of children and adolescents. Journal of Autism and Developmental Disorders, 42(7), 1304–1313.CrossRef Mandy, W., Chilvers, R., Chowdhury, U., Salter, G., Seigal, A., & Skuse, D. (2011). Sex differences in autism spectrum disorder: Evidence from a large sample of children and adolescents. Journal of Autism and Developmental Disorders, 42(7), 1304–1313.CrossRef
go back to reference McLennan, J., Lord, C., & Schopler, E. (1993). Sex differences in higher functioning people with autism. Journal of Autism and Developmental Disorders, 23(2), 217–227.PubMedCrossRef McLennan, J., Lord, C., & Schopler, E. (1993). Sex differences in higher functioning people with autism. Journal of Autism and Developmental Disorders, 23(2), 217–227.PubMedCrossRef
go back to reference McMahon, W., & Ritvo, A. (1989). The UCLA-University of Utah epidemiologic survey of autism: Prevalence. American Journal of Psychiatry, 146, 194–199.PubMedCrossRef McMahon, W., & Ritvo, A. (1989). The UCLA-University of Utah epidemiologic survey of autism: Prevalence. American Journal of Psychiatry, 146, 194–199.PubMedCrossRef
go back to reference McPartland, J., Cheung, C. H., Perszyk, D., & Mayes, L. C. (2010). Face-related ERPs are modulated by point of gaze. Neuropsychologia, 48(12), 3657–3660. McPartland, J., Cheung, C. H., Perszyk, D., & Mayes, L. C. (2010). Face-related ERPs are modulated by point of gaze. Neuropsychologia, 48(12), 3657–3660.
go back to reference Moore, T. (1967). Language and intelligence: A longitudinal study of the first eight years. Human Development, 10(2), 86–106.CrossRef Moore, T. (1967). Language and intelligence: A longitudinal study of the first eight years. Human Development, 10(2), 86–106.CrossRef
go back to reference O’Connor, K., Hamm, J. P., & Kirk, I. J. (2005). The neurophysiological correlates of face processing in adults and children with Asperger’s syndrome. Brain and Cognition, 59, 82–95.PubMedCrossRef O’Connor, K., Hamm, J. P., & Kirk, I. J. (2005). The neurophysiological correlates of face processing in adults and children with Asperger’s syndrome. Brain and Cognition, 59, 82–95.PubMedCrossRef
go back to reference Pavlova, M., Guerreschi, M., Lutzenberger, W., Sokolov, A., & Krageloh-Mann, I. (2012). Cortical response to social interaction is affected by gender. Neuroimage, 50, 1327–1332.CrossRef Pavlova, M., Guerreschi, M., Lutzenberger, W., Sokolov, A., & Krageloh-Mann, I. (2012). Cortical response to social interaction is affected by gender. Neuroimage, 50, 1327–1332.CrossRef
go back to reference Piefke, M., Weiss, P., Markowitsch, H., & Fink, G. (2005). Gender differences in the functional neuroanatomy of emotional episodic autobiographical memory. Human Brain Mapping, 24(4), 313–324.PubMedCrossRef Piefke, M., Weiss, P., Markowitsch, H., & Fink, G. (2005). Gender differences in the functional neuroanatomy of emotional episodic autobiographical memory. Human Brain Mapping, 24(4), 313–324.PubMedCrossRef
go back to reference Proverbio, A., Brignone, V., Matarazzo, S., Del Zotto, M., & Zani, A. (2006). Gender differences in hemispheric asymmetry for face processing. BMC Neuroscience, 7(1), 44. Proverbio, A., Brignone, V., Matarazzo, S., Del Zotto, M., & Zani, A. (2006). Gender differences in hemispheric asymmetry for face processing. BMC Neuroscience, 7(1), 44.
go back to reference Pugh, K., Shaywitz, B., Shaywitz, S., Constable, T., Skudlarski, P., Fulbright, R., et al. (1996). Cerebral organization of component processes in reading. Brain, 119, 1221–1238.PubMedCrossRef Pugh, K., Shaywitz, B., Shaywitz, S., Constable, T., Skudlarski, P., Fulbright, R., et al. (1996). Cerebral organization of component processes in reading. Brain, 119, 1221–1238.PubMedCrossRef
go back to reference Rossion, B., Campanella, S., Gomez, C., Delinte, A., Debatisse, D., Liard, L., et al. (1999). Task modulation of brain activity related to familiar and unfamiliar face processing: An ERP study. Clinical Neurophysiology, 110, 449–462.PubMedCrossRef Rossion, B., Campanella, S., Gomez, C., Delinte, A., Debatisse, D., Liard, L., et al. (1999). Task modulation of brain activity related to familiar and unfamiliar face processing: An ERP study. Clinical Neurophysiology, 110, 449–462.PubMedCrossRef
go back to reference Schneider, W., Eschman, A., & Zuccolotto, A. (2002). E-prime user’s guide. Pittsburg: Psychology Software Tools Inc. Schneider, W., Eschman, A., & Zuccolotto, A. (2002). E-prime user’s guide. Pittsburg: Psychology Software Tools Inc.
go back to reference Scott, F., Baron-Cohen, S., Bolton, P., & Brayne, C. (2002). Brief report: Prevalence of autism spectrum conditions in children aged 5–11 years in Cambridgeshire, UK. Autism, 6(3), 231–237.PubMedCrossRef Scott, F., Baron-Cohen, S., Bolton, P., & Brayne, C. (2002). Brief report: Prevalence of autism spectrum conditions in children aged 5–11 years in Cambridgeshire, UK. Autism, 6(3), 231–237.PubMedCrossRef
go back to reference Sparrow, S., Cicchetti, D., & Balla, D. (2005). Vineland Adaptive Behavior Scales (2nd ed.). Bloomington: Pearson. Sparrow, S., Cicchetti, D., & Balla, D. (2005). Vineland Adaptive Behavior Scales (2nd ed.). Bloomington: Pearson.
go back to reference Taylor, M. J., Batty, M., & Itier, R. J. (2004). The faces of development: A review of early face processing over childhood. Journal of Cognitive Neuroscience, 16(8), 1426–1442.PubMedCrossRef Taylor, M. J., Batty, M., & Itier, R. J. (2004). The faces of development: A review of early face processing over childhood. Journal of Cognitive Neuroscience, 16(8), 1426–1442.PubMedCrossRef
go back to reference Tsai, L. Y., & Beisler, J. M. (1983). The development of sex differences in infantile autism. The British Journal of Psychiatry, 142(4), 373–378. Tsai, L. Y., & Beisler, J. M. (1983). The development of sex differences in infantile autism. The British Journal of Psychiatry, 142(4), 373–378.
go back to reference Tucker, D. (1993). Spatial sampling of head electrical fields: The geodesic sensor net. Electroencephalography and Clinical Neurophysiology, 87(3), 154–163.PubMedCrossRef Tucker, D. (1993). Spatial sampling of head electrical fields: The geodesic sensor net. Electroencephalography and Clinical Neurophysiology, 87(3), 154–163.PubMedCrossRef
go back to reference Volkmar, F., Szatmari, P., & Sparrow, S. (1993). Sex differences in pervasive developmental disorders. Journal of Autism and Developmental Disorders, 23(4), 579–591.PubMedCrossRef Volkmar, F., Szatmari, P., & Sparrow, S. (1993). Sex differences in pervasive developmental disorders. Journal of Autism and Developmental Disorders, 23(4), 579–591.PubMedCrossRef
go back to reference Wechsler, D. (1997). Manual for the Wechsler Adult Intelligence Scale (3rd ed.). San Antonio, TX: The Psychological Corporation. Wechsler, D. (1997). Manual for the Wechsler Adult Intelligence Scale (3rd ed.). San Antonio, TX: The Psychological Corporation.
go back to reference Wing, L. (1981). Sex ratios in early childhood autism and related conditions. Psychiatry Research, 5, 129–137.PubMedCrossRef Wing, L. (1981). Sex ratios in early childhood autism and related conditions. Psychiatry Research, 5, 129–137.PubMedCrossRef
go back to reference Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003). Prevalence of autism in a US metropolitan area. The Journal of the American Medical Association, 289(1), 49–55. Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003). Prevalence of autism in a US metropolitan area. The Journal of the American Medical Association, 289(1), 49–55.
Metagegevens
Titel
Sex Differences in Social Perception in Children with ASD
Auteurs
M. C. Coffman
L. C. Anderson
A. J. Naples
J. C. McPartland
Publicatiedatum
01-02-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-2006-5

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