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Gepubliceerd in: Journal of Autism and Developmental Disorders 12/2012

01-12-2012 | Original Paper

Sex Differences in Children with Autism Spectrum Disorder Identified Within a High-Risk Infant Cohort

Auteurs: Lonnie Zwaigenbaum, Susan E. Bryson, Peter Szatmari, Jessica Brian, Isabel M. Smith, Wendy Roberts, Tracy Vaillancourt, Caroline Roncadin

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2012

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Abstract

Sex differences were examined in 3-year-olds with autism spectrum disorders (ASD) ascertained from a high-risk cohort, and high- and low-risk comparison groups. Participants included 319 high-risk siblings and 129 low-risk controls. Eighty-five siblings were diagnosed with ASD, including 57 of 176 boys (32.4 %) and 28 of 143 girls (19.6 %), implying a relative odds of ASD of 1.65 in boys versus girls. There were modest sex differences on cognitive and adaptive skills and ASD symptom severity at age 3, but differences between boys and girls with ASD mirrored those in the non-ASD groups. The lower than expected male-to-female ratio, and the relatively high cognitive level among diagnosed children, suggest that we have identified an unanticipated number of higher-functioning girls with ASD.

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Voetnoten
1
Of 85 HR siblings clinically diagnosed with ASD, 78 met criteria on the ADOS, 52 met criteria on the ADI-R and 48 met criteria on both. Only 3 children diagnosed with ASD were sub-threshold on both the ADOS and ADI-R at 3 years, 2 of whom met ADOS criteria for ASD and received initial clinical diagnoses at 24 months.
 
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Metagegevens
Titel
Sex Differences in Children with Autism Spectrum Disorder Identified Within a High-Risk Infant Cohort
Auteurs
Lonnie Zwaigenbaum
Susan E. Bryson
Peter Szatmari
Jessica Brian
Isabel M. Smith
Wendy Roberts
Tracy Vaillancourt
Caroline Roncadin
Publicatiedatum
01-12-2012
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 12/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-012-1515-y