Skip to main content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Child Psychiatry & Human Development 2/2022

03-02-2021 | Original Article

Serum Galanin in Children with Autism Spectrum Disorder

Auteurs: Khaled Saad, Ahmed A. Abdel-Rahman, Abdulrahman A. Al-Atram, Alam-Eldin M. Abdallah, Amira Elhoufey, Eman M. Nagiub Abdelsalam, Dalia A. Nigm, Ola Elshora, Ahmad Roshdy Ahmad, Mohamed M. El-Tellawy, Khaled Hashim Mahmoud

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 2/2022

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Recent studies have attempted to measure several biomarkers to understand the complex interactions of the anatomic systems that may be involved in autism spectrum disorder (ASD). In CNS, galanin takes part in a variety of pathological and physiological processes. Prior research has indicated it is involved in several neuropsychiatric disorders and has a role in inhibiting the neuronal firing and release of serotonin, norepinephrine, and acetylcholine. To date, serum galanin levels have not been investigated in the context of ASD. This study aimed, therefore, to compare the serum galanin levels of children with ASD and healthy controls and to reveal any association between galanin level and the severity of ASD, as well as other psychological and demographic parameters. Serum galanin levels were measured by radioimmunoassay in 116 children with ASD and 98 healthy children. We observed significantly increased serum concentrations of galanin in children with ASD relative to healthy children. Moreover, children with severe ASD had significantly higher galanin levels than those with less severe disease. We also confirmed significant positive correlations between galanin and psychiatric parameters in children with ASD. For the first time, we suggest a possible correlation between serum galanin and the degree of ASD severity. Increased galanin levels may play a role in the pathogenesis of ASD.
Literatuur
12.
go back to reference American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders 5. American Psychiatric Association, Washington, DC CrossRef American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders 5. American Psychiatric Association, Washington, DC CrossRef
14.
go back to reference Schopler E, Van Bourgondien ME, Wellman GJ (2010) Childhood Autism Rating Scale, 2nd edn. Western Psychological Services, Los Angeles Schopler E, Van Bourgondien ME, Wellman GJ (2010) Childhood Autism Rating Scale, 2nd edn. Western Psychological Services, Los Angeles
Metagegevens
Titel
Serum Galanin in Children with Autism Spectrum Disorder
Auteurs
Khaled Saad
Ahmed A. Abdel-Rahman
Abdulrahman A. Al-Atram
Alam-Eldin M. Abdallah
Amira Elhoufey
Eman M. Nagiub Abdelsalam
Dalia A. Nigm
Ola Elshora
Ahmad Roshdy Ahmad
Mohamed M. El-Tellawy
Khaled Hashim Mahmoud
Publicatiedatum
03-02-2021
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 2/2022
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-021-01127-4

Andere artikelen Uitgave 2/2022

Child Psychiatry & Human Development 2/2022 Naar de uitgave