Top

Gepubliceerd in:

01-12-2013

Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: the Young Finns study

Auteurs: Christian Hakulinen, Markus Jokela, Mirka Hintsanen, Päivi Merjonen, Laura Pulkki-Råback, Ilkka Seppälä, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Mika Kähönen, Jorma Viikari, Olli T. Raitakari, Liisa Keltikangas-Järvinen

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 6/2013

Abstract

The serotonin system has been shown to be involved in the regulation of hostility, anger, and aggressive behavior. Previous molecular genetic studies suggest that the serotonin receptor 1B (HTR1B) rs6296 genotype might have a particular role in these types of behaviors. We examined whether HTR1B is related to hostility, anger, and aggressive behavior phenotypes over a lifespan and whether it modifies the connection between childhood aggressive behavior and adulthood hostility and anger. The participants were 967 women and men from a large population based sample (The Young Finns Study) with a 27-year follow-up. Childhood aggressive behavior was reported by the mother twice when the participants were 3 to 12 years of age. Adulthood hostility and anger were self-reported by the participants between ages 24 and 36. Childhood aggressive behavior predicted adulthood hostility over 27 years. HTR1B SNP rs6296 was associated with childhood aggressive behavior but not with adulthood anger or hostility. The HTR1B SNP rs6296 modified the association between childhood aggressive behavior and adulthood hostility. Aggressive behavior and hostility might form a life course pattern, and the HTR1B might contribute to a development of this pattern.

vorige artikel Weight loss history as a predictor of weight loss: results from Phase I of the weight loss maintenance trial

volgende artikel Characterizing the psychological distress response before and after a cancer diagnosis

Åkerblom, H. K., Uhari, M., Pesonen, E., Dahl, M., Kaprio, E. A., Nuutinen, E. M., et al. (1991). Cardiovascular risk in Young Finns. Annals of Medicine, 23, 35–39.PubMedCrossRef

Barefoot, J. C., Dahlstrom, W. G., & Williams, R. B., Jr. (1983). Hostility, CHD incidence, and total mortality: A 25-year follow-up study of 255 physicians. Psychosomatic Medicine, 45, 59–63.PubMed

Barefoot, J. C., Peterson, B. L., Dahlstrom, W. G., Siegler, I. C., Anderson, N. B., & Williams, R. B., Jr. (1991). Hostility patterns and health implications: Correlates of cook-medley hostility scale scores in a national survey. Health Psychology, 10, 18.PubMedCrossRef

Belsky, J., Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2007). For better and for worse. Current Directions in Psychological Science, 16, 300–304.CrossRef

Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885–908.PubMedCrossRef

Brummett, B. H., Boyle, S. H., Siegler, I. C., Kuhn, C. M., Ashley-Koch, A., Jonassaint, C. R., et al. (2008). Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behavior Genetics, 38, 34–43.PubMedCrossRef

Buss, A. H. (1991). The EAS theory of temperament. In J. Strelau & A. Angleitner (Eds.), Explorations in temperament: International perspectives on theory and measurement, perspectives on individual differences (pp. 43–60). New York: Plenum Press.

Buss, A. H., & Durkee, A. (1957). An inventory for assessing different kinds of hostility. Journal of Consulting Psychology, 21, 343–349.PubMedCrossRef

Caspi, A. (2000). The child is father of the man: Personality continuities from childhood to adulthood. Journal of Personality and Social Psychology, 78, 158–172.PubMedCrossRef

Caspi, A., Harrington, H. L., Milne, B., Amell, J. W., Theodore, R. F., & Moffitt, T. E. (2003). Children’s behavioral styles at age 3 are linked to their adult personality traits at age 26. Journal of Personality, 71, 495–514.PubMedCrossRef

Chang, P. P., Ford, D. E., Meoni, L. A., Wang, N. Y., & Klag, M. J. (2002). Anger in young men and subsequent premature cardiovascular disease: The precursors study. Archives of Internal Medicine, 162, 901–906.PubMedCrossRef

Chida, Y., & Steptoe, A. (2009). The association of anger and hostility with future coronary heart disease: A meta-analytic review of prospective evidence. Journal of the American College of Cardiology, 53, 936–946.PubMedCrossRef

Comrey, A. L. (1957). A factor analysis of items on the MMPI hysteria scale. Educational and Psychological Measurement, 17, 586–592.

Comrey, A. L. (1958). A factor analysis of items on the MMPI paranoia scale. Educational and Psychological Measurement, 18, 99–107.CrossRef

Conner, T. S., Jensen, K. P., Tennen, H., Furneaux, H. M., Kranzler, H. R., & Covault, J. (2010). Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153, 67–78.

Craig, I. W., & Halton, K. E. (2009). Genetics of human aggressive behaviour. Human Genetics, 126, 101–113.PubMedCrossRef

Davidge, K. M., Atkinson, L., Douglas, L., Lee, V., Shapiro, S., Kennedy, J. L., et al. (2004). Association of the serotonin transporter and 5HT1D [beta] receptor genes with extreme, persistent and pervasive aggressive behaviour in children. Psychiatric Genetics, 14, 143–146.PubMedCrossRef

Derogatis, L. R. (1977). SCL-90R (revised) version manual-1. Baltimore: John Hopkins University Press.

Duan, J., Sanders, A., Vander Molen, J., Martinolich, L., Mowry, B., Levinson, D., et al. (2003). Polymorphisms in the 5′-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression. Molecular Psychiatry, 8, 901–910.

Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: An evolutionary-neurodevelopmental theory. Development and Psychopathology, 23, 7–28.PubMedCrossRef

Elovainio, M., Merjonen, P., Pulkki-Råback, L., Kivimäki, M., Jokela, M., Mattson, N., et al. (2011). Hostility, metabolic syndrome, inflammation and cardiac control in young adults: The Young Finns study. Biological Psychology, 87, 234–240.PubMedCrossRef

Everson, S. A., Kauhanen, J., Kaplan, G. A., Goldberg, D. E., Julkunen, J., Tuomilehto, J., et al. (1997). Hostility and increased risk of mortality and acute myocardial infarction: The mediating role of behavioral risk factors. American Journal of Epidemiology, 146, 142–152.PubMedCrossRef

Gallacher, J. E. J., Yarnell, J. W. G., Sweetnam, P. M., Elwood, P. C., & Stansfeld, S. A. (1999). Anger and incident heart disease in the caerphilly study. Psychosomatic Medicine, 61, 446–453.PubMed

Gottlieb, G. (2007). Probabilistic epigenesis. Developmental Science, 10, 1–11.PubMedCrossRef

Haukkala, A. (2002). Socio-economic differences in hostility measures: a population based study. Psychology and Health, 17, 191–202.CrossRef

Huang, Y., Grailhe, R., Arango, V., Hen, R., & Mann, J. J. (1999). Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue. Neuropsychopharmacology, 21, 238–246.PubMedCrossRef

Huesmann, L. R., Eron, L. D., Lefkowitz, M. M., & Walder, L. O. (1984). Stability of aggression over time and generations. Developmental Psychology, 20, 1120–1134.CrossRef

Hur, Y. M. (2006). Nonadditive genetic effects on hostility in South Korean adolescent and young adult twins. Twin Research and Human Genetics, 9, 637–641.PubMedCrossRef

Jacobson, N. S., Gottman, J. M., Waltz, J., Rushe, R., Babcock, J., & Holtzworth-Munroe, A. (1994). Affect, verbal content, and psychophysiology in the arguments of couples with a violent husband. Journal of Consulting and Clinical Psychology, 62, 982–988.PubMedCrossRef

Jensen, K. P., Covault, J., Conner, T. S., Tennen, H., Kranzler, H. R., & Furneaux, H. M. (2009). A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors. Molecular Psychiatry, 14, 381–389.PubMedCrossRef

Jokela, M., Keltikangas-Järvinen, L., Kivimäki, M., Puttonen, S., Elovainio, M., Rontu, R., et al. (2007). Serotonin receptor 2A gene and the influence of childhood maternal nurturance on adulthood depressive symptoms. Archives of General Psychiatry, 64, 356–360.PubMedCrossRef

Kandler, C., Bleidorn, W., Riemann, R., Angleitner, A., & Spinath, F. M. (2012). Life events as environmental states and genetic traits and the role of personality: A longitudinal twin study. Behavior Genetics, 42, 57–72.PubMedCrossRef

Keltikangas-Järvinen, L., & Heinonen, K. (2003). Childhood roots of adulthood hostility: Family factors as predictors of cognitive and affective hostility. Child Development, 74, 1751–1768.PubMedCrossRef

Keltikangas-Järvinen, L., Puttonen, S., Kivimäki, M., Elovainio, M., Pulkki-Råback, L., Koivu, M., et al. (2008). Serotonin receptor genes 5HT1A and 5HT2A modify the relation between childhood temperament and adulthood hostility. Genes, Brain and Behavior, 7, 46–52.

Keltikangas-Järvinen, L., & Räikkönen, K. (1989). Pathogenic and protective factors of type A behavior in adolescents. Journal of Psychosomatic Research, 33, 591–602.PubMedCrossRef

Keltikangas-Järvinen, L., & Räikkönen, K. (1990). Type a factors as predictors of somatic risk factors of coronary heart disease in Young Finns: A six-year follow-up study. Journal of Psychosomatic Research, 34, 89–97.PubMedCrossRef

Kokko, K., Pulkkinen, L., Huesmann, L. R., Dubow, E. F., & Boxer, P. (2009). Intensity of aggression in childhood as a predictor of different forms of adult aggression: A two-country (Finland and the United States) analysis. Journal of Research on Adolescence, 19, 9–34. doi:10.1111/j.1532-7795.2009.00579x PubMedCrossRef

Koskenvuo, M., Kaprio, J., Rose, R. J., Kesäniemi, A., Sarna, S., Heikkilä, K., et al. (1988). Hostility as a risk factor for mortality and ischemic heart disease in men. Psychosomatic Medicine, 50, 330–340.PubMed

Kubzansky, L. D., Cole, S. R., Kawachi, I., Vokonas, P., & Sparrow, D. (2006). Shared and unique contributions of anger, anxiety, and depression to coronary heart disease: A prospective study in the normative aging study. Annals of Behavioral Medicine, 31, 21–29.PubMedCrossRef

Lappalainen, J., Long, J. C., Eggert, M., Ozaki, N., Robin, R. W., Brown, G. L., et al. (1998). Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Archives of General Psychiatry, 55, 989–994.PubMedCrossRef

Lesch, K. P., & Merschdorf, U. (2000). Impulsivity, aggression, and serotonin: A molecular psychobiological perspective. Behavioral Sciences & the Law, 18, 581–604.CrossRef

MacCallum, R. C., Zhang, S., Preacher, K. J., & Rucker, D. D. (2002). On the practice of dichotomization of quantitative variables. Psychological Methods, 7, 19–40.PubMedCrossRef

Matthews, K. A., & Angulo, J. (1980). Measurement of the type A behavior pattern in children: Assessment of children’s competitiveness, impatience-anger, and aggression. Child Development, 51, 466–475.PubMedCrossRef

Matthews, K. A., & Haynes, S. C. (1986). Type A behavior pattern and coronary disease risk update and critical evaluation. American Journal of Epidemiology, 123, 923–960.PubMed

Matthews, K. A., Woodall, K. L., Kenyon, K., & Jacob, T. (1996). Negative family environment as a predictor of boy’s future status on measures of hostile attitudes, interview behavior, and anger expression. Health Psychology, 15, 30–37.PubMedCrossRef

Merjonen, P., Keltikangas-Järvinen, L., Jokela, M., Seppälä, I., Lyytikäinen, L., Pulkki-Råback, L., et al. (2011a). Hostility in adolescents and adults: A genome-wide association study of the Young Finns. Translational Psychiatry, 1, e11.PubMedCrossRef

Merjonen, P., Pulkki-Råback, L., & Keltikangas-Järvinen, L. (2007). Anger and cardiovascular health. In E. I. Clausen (Ed.), Psychology of anger (pp. 71–106). New York: Nova science.

Merjonen, P., Pulkki-Råback, L., Lipsanen, J., Lehtimäki, T., Rontu, R., Viikari, J., et al. (2011b). Development of adulthood hostile attitudes: Childhood environment and serotonin receptor gene interactions. Personal Relationships, 18, 184–197.CrossRef

Merjonen, P., Pulkki-Råback, L., Puttonen, S., Keskivaara, P., Juonala, M., Telama, R., et al. (2008). Anger is associated with subclinical atherosclerosis in low SES but not in higher SES men and women. The cardiovascular risk in young finns study. Journal of Behavioral Medicine, 31, 35–44.PubMedCrossRef

Miles, D. R., & Carey, G. (1997). Genetic and environmental architecture of human aggression. Journal of Personality and Social Psychology, 72, 207–217.PubMedCrossRef

Miller, T. Q., Smith, T. W., Turner, C. W., Guijarro, M. L., & Hallet, A. J. (1996). Meta-analytic review of research on hostility and physical health. Psychological Bulletin, 119, 322.PubMedCrossRef

Moreno, J. K., Fuhriman, A., & Selby, M. J. (1993). Measurement of hostility, anger, and depression in depressed and nondepressed subjects. Journal of Personality Assessment, 61, 511–523.PubMedCrossRef

Nabi, H., Singh-Manoux, A., Ferrie, J. E., Marmot, M. G., Melchior, M., & Kivimäki, M. (2010). Hostility and depressive mood: Results from the Whitehall II prospective cohort study. Psychological Medicine, 40, 405–413.PubMedCrossRef

New, A. S., Gelernter, J., Goodman, M., Mitropoulou, V., Koenigsberg, H., Silverman, J., et al. (2001). Suicide, impulsive aggression, and HTR1B genotype. Biological Psychiatry, 50, 62–65.PubMedCrossRef

Niaura, R., Banks, S. M., Ward, K. D., Stoney, C. M., Spiro, A., I. I. I., Aldwin, C. M., et al. (2000). Hostility and the metabolic syndrome in older males: The normative aging study. Psychosomatic Medicine, 62, 7–16.PubMed

Pulkki-Råback, L., Elovainio, M., Kivimäki, M., Mattsson, N., Raitakari, O. T., Puttonen, S., et al. (2009). Depressive symptoms and the metabolic syndrome in childhood and adulthood: A prospective cohort study. Health Psychology, 28, 108–116.PubMedCrossRef

Räikkönen, K., Katainen, S., Keskivaara, P., & Keltikangas-Järvinen, L. (2000). Temperament, mothering, and hostile attitudes: A 12-year longitudinal study. Personality and Social Psychology Bulletin, 26, 3–12.

Raitakari, O. T., Juonala, M., Rönnemaa, T., Keltikangas-Järvinen, L., Räsänen, L., Pietikäinen, M., et al. (2008). Cohort profile: The cardiovascular risk in Young Finns study. International Journal of Epidemiology, 37, 1220–1226.PubMedCrossRef

Rebollo, I., & Boomsma, D. I. (2006). Genetic analysis of anger: Genetic dominance or competitive sibling interaction. Behavior Genetics, 36, 216–228.PubMedCrossRef

Repetti, R. L., Taylor, S. E., & Seeman, T. E. (2002). Risky families: Family social environments and the mental and physical health of offspring. Psychological Bulletin, 128, 330–366.PubMedCrossRef

Salo, J., Jokela, M., Lehtimäki, T., & Keltikangas-Järvinen, L. (2011). Serotonin receptor 2A gene moderates the effect of childhood maternal nurturance on adulthood social attachment. Genes, Brain and Behavior, 10, 702–709.CrossRef

Sanders, A. R., Duan, J., & Gejman, P. V. (2002). DNA variation and psychopharmacology of the human serotonin receptor 1B (HTR1B) gene. Pharmacogenomics, 3, 745–762.PubMedCrossRef

Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Segu, L., et al. (1994). Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science, 265, 1875–1878.PubMedCrossRef

Smith, T. W. (1992). Hostility and health: Current status of a psychosomatic hypothesis. Health Psychology, 11, 139–150.PubMedCrossRef

Smith, E. N., Chen, W., Kähönen, M., Kettunen, J., Lehtimäki, T., Peltonen, L., et al. (2010). Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. PLoS Genetics, 6, e1001094.PubMedCrossRef

Smith, T. W., Glazer, K., Ruiz, J. M., & Gallo, L. C. (2004). Hostility, anger, aggressiveness, and coronary heart disease: An interpersonal perspective on personality, emotion, and health. Journal of Personality, 72, 1217–1270.PubMedCrossRef

Thoresen, C. E., & Pattillo, J. R. (1988). Exploring the type A behavior pattern in children and adolescents. In B. K. Houston & C. R. Snyder (Eds.), Type A behavior pattern: Research, theory, and intervention.wiley series on health psychology/behavioral medicine (pp. 98–145). Oxford, England: John Wiley & Sons.

Tindle, H. A., Chang, Y. F., Kuller, L. H., Manson, J. A. E., Robinson, J. G., Rosal, M. C., et al. (2009). Optimism, cynical hostility, and incident coronary heart disease and mortality in the women’s health initiative. Circulation, 120, 656–662.PubMedCrossRef

Williams, R. B. (1994). Basic biological mechanisms. In A. W. Siegman & T. W. Smith (Eds.), Anger, hostility, and the heart (pp. 117–125). Hillsdale: Erlbaum.

Williams, R. B., Marchuk, D. A., Gadde, K., Barefoot, J. C., Grichnik, K., Helms, M. J., et al. (2003). Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology, 28, 541.CrossRef

Williams, J. E., Nieto, F. J., Sanford, C. P., & Tyroler, H. A. (2001). Effects of an angry temperament on coronary heart disease risk. American Journal of Epidemiology, 154, 230–235.

Titel: Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: the Young Finns study
Auteurs: Christian Hakulinen
Markus Jokela
Mirka Hintsanen
Päivi Merjonen
Laura Pulkki-Råback
Ilkka Seppälä
Leo-Pekka Lyytikäinen
Terho Lehtimäki
Mika Kähönen
Jorma Viikari
Olli T. Raitakari
Liisa Keltikangas-Järvinen
Publicatiedatum: 01-12-2013
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 6/2013
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-012-9452-y

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 6/2013

Attentional bias for prescription opioid cues among opioid dependent chronic pain patients

Beating and insulting children as a risk for adult cancer, cardiac disease and asthma

Knowing your partner is not enough: spousal importance moderates the link between attitude familiarity and ambulatory blood pressure

Characterizing the psychological distress response before and after a cancer diagnosis

Correlates of health-related quality of life, psychological well-being, and eating self-regulation after successful weight loss maintenance

Cardiovascular reactivity during stressful speaking tasks in Mexican–American women: effects of language use and interaction partner ethnicity