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Gepubliceerd in: Quality of Life Research 9/2022

29-03-2022

Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial

Auteurs: Johan S. Bundgaard, Kasper Iversen, Mia Pries-Heje, Nikolaj Ihlemann, Sabine U. Gill, Trine Madsen, Hanne Elming, Jonas A. Povlsen, Niels E. Bruun, Dan E. Høfsten, Kurt Fuursted, Jens J. Christensen, Martin Schultz, Flemming Rosenvinge, Jannik Helweg‑Larsen, Lars Køber, Christian Torp‑Pedersen, Emil L. Fosbøl, Niels Tønder, Claus Moser, Henning Bundgaard, Ulrik M. Mogensen

Gepubliceerd in: Quality of Life Research | Uitgave 9/2022

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Abstract

Purpose

Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis.

Methods

This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model.

Results

Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4–34.8) and 5.4 (95% CI 4.1–7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7–7.0, p < 0.01).

Conclusion

Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257.

Trial registry

POET ClinicalTrials.gov number, NCT01375257.
Bijlagen
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Metagegevens
Titel
Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial
Auteurs
Johan S. Bundgaard
Kasper Iversen
Mia Pries-Heje
Nikolaj Ihlemann
Sabine U. Gill
Trine Madsen
Hanne Elming
Jonas A. Povlsen
Niels E. Bruun
Dan E. Høfsten
Kurt Fuursted
Jens J. Christensen
Martin Schultz
Flemming Rosenvinge
Jannik Helweg‑Larsen
Lars Køber
Christian Torp‑Pedersen
Emil L. Fosbøl
Niels Tønder
Claus Moser
Henning Bundgaard
Ulrik M. Mogensen
Publicatiedatum
29-03-2022
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 9/2022
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-022-03126-x

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