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06-02-2021 | Original Paper

Rethinking Measurement Standards of Autism Symptomology in Adolescents with Fragile X Syndrome

Auteurs: Heather Fielding-Gebhardt, Shelley L. Bredin-Oja, Steven F. Warren, Nancy C. Brady

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 12/2021

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Abstract

Accurate representation of autism spectrum disorder (ASD) in fragile X syndrome (FXS) is necessary for the field. We examined classifications of ASD using three approaches—Autism Diagnostic Observation Schedule (ADOS-2; Lord et al. 2012), Childhood Autism Rating Scale (CARS2-ST; Schopler et al. 2010), and Vineland Adaptive Behavior Scales (VABS-II; Sparrow et al. 2005)—in 45 adolescents with FXS. Maladaptive items from the VABS-II plus a maternal interview were matched with Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5; American Psychiatric Association 2013) criteria for ASD. Results indicated discrepant classifications. The ADOS-2 yielded the highest rate of comorbid autism (71%); CARS2-ST and VABS-II/DSM-5 yielded lower rates (38% and 42%, respectively). A singular measure of autism symptomology is insufficient to characterize autism in FXS.
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Metagegevens
Titel
Rethinking Measurement Standards of Autism Symptomology in Adolescents with Fragile X Syndrome
Auteurs
Heather Fielding-Gebhardt
Shelley L. Bredin-Oja
Steven F. Warren
Nancy C. Brady
Publicatiedatum
06-02-2021
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 12/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-021-04892-2