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Quality of Life Research
Gepubliceerd in: Quality of Life Research 4/2010

01-05-2010

Restless legs syndrome and its relationship with anxiety, depression, and quality of life in cancer patients undergoing chemotherapy

Auteurs: Luca Ostacoli, Andrea Saini, Luigi Ferini-Strambi, Vincenza Castronovo, Erica Sguazzotti, Rocco Luigi Picci, Mario Toje, Gabriella Gorzegno, Serena Capogna, Vincenzo Dongiovanni, Luigi Dogliotti, Pier Maria Furlan, Alfredo Berruti

Gepubliceerd in: Quality of Life Research | Uitgave 4/2010

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Abstract

Objective

Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by uncomfortable and unpleasant sensations in the legs that are relieved by movement. This study evaluated the prevalence of RLS in a consecutive series of cancer patients during chemotherapy and examined the relationship between presence of RLS and quality of life, anxiety, and depressive symptoms in these patients.

Methods

RLS was assessed according to the International RLS Study Group essential diagnostic criteria in two stages: a screening questionnaire first, followed by a sleep specialist–conducted structured diagnostic interview. The following questionnaires were administered: Functional Assessment of Cancer Therapy-General (FACT-G) for Quality-of-life (QoL) assessment; Hospital Anxiety and Depression Scale (HADS) to evaluate the levels of anxiety and depression; and Mini Mental Adjustment to Cancer Scale (Mini-MAC) to assess coping styles.

Results

A total of 257 patients were evaluated. Among them 56 were identified by the screening questionnaire to meet the criteria for RLS and 47 of whom were confirmed as affected by RLS after a structured interview, rendering a prevalence rate of 18.3%. RLS was significantly more frequent in women than men (23.7 vs. 11.8%; P = 0.01), and in patients receiving antineoplastic therapies for more than 3 months than their counterpart (21.8 vs. 10.8%; P = 0.03). Compared with those without RLS, patients with RLS had higher levels of anxiety (P = 0.0009) and depression (P = 0.001) and lower quality of life (P = 0.006). Sex-chemotherapy-duration-adjusted odds ratios of anxiety and physical well-being associated with RLS were 1.1 (95% CI 1.00–1.19; P = 0.04) and 0.7 (95% CI 0.43–1.01; P = 0.04), respectively.

Conclusions

The prevalence of RLS in cancer patients undergoing chemotherapy is 18.3%, about double of that expected in the general population. The occurrence of RLS is much more frequent in female patients and with longer-term chemotherapy. Cancer patients afflicted by RLS have significantly higher levels of anxiety and depression, and poorer quality of life especially in the physical well-being dimension. Recognition and treatment of RLS in cancer patients is an important target in clinical management and may improve quality of life and overall health outcomes in these patients.
vorige artikel Proxy and patients ratings on quality of life in patients with schizophrenia and bipolar disorder in Korea
volgende artikel The COSMIN checklist for assessing the methodological quality of studies on measurement properties of health status measurement instruments: an international Delphi study
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Metagegevens
Titel
Restless legs syndrome and its relationship with anxiety, depression, and quality of life in cancer patients undergoing chemotherapy
Auteurs
Luca Ostacoli
Andrea Saini
Luigi Ferini-Strambi
Vincenza Castronovo
Erica Sguazzotti
Rocco Luigi Picci
Mario Toje
Gabriella Gorzegno
Serena Capogna
Vincenzo Dongiovanni
Luigi Dogliotti
Pier Maria Furlan
Alfredo Berruti
Publicatiedatum
01-05-2010
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 4/2010
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-010-9614-8

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