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Gepubliceerd in:

01-09-2012

Resting-State Oscillatory Activity in Autism Spectrum Disorders

Auteurs: Lauren Cornew, Timothy P. L. Roberts, Lisa Blaskey, J. Christopher Edgar

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2012

Abstract

Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), and high frequency (20–120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest.

vorige artikel The Rubber Hand Illusion Reveals Proprioceptive and Sensorimotor Differences in Autism Spectrum Disorders

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Titel: Resting-State Oscillatory Activity in Autism Spectrum Disorders
Auteurs: Lauren Cornew
Timothy P. L. Roberts
Lisa Blaskey
J. Christopher Edgar
Publicatiedatum: 01-09-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 9/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-011-1431-6

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