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25-09-2020 | Original Paper

Resting and Functional Pupil Response Metrics Indicate Features of Reward Sensitivity and ASD in Children

Auteurs: Antoinette Sabatino DiCriscio, Vanessa Troiani

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2021

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Abstract

The current study examined the relationship between quantitative measures of reward and punishment sensitivity, features of autism spectrum disorder (ASD), and resting and functional pupil response metrics across a clinically heterogeneous sample. Scores on a parent-report measure of punishment and reward sensitivity were correlated with ASD features. We also assessed whether pupil measurements could be used as a physiologic correlate of reward sensitivity and predictor of ASD diagnosis. In a logistic regression model, pupil dilation metrics, sex, and IQ, correctly classified 86.3% of participants as having an ASD diagnosis versus not. This research highlights individual differences of reward sensitivity associated with ASD features. Results support the use of pupil metrics and other patient-level variables as predictors of ASD diagnostic status.
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1
To be included in analyses, we required participants to maintain fixation on screen during the baseline period and successfully complete at least 50% of trials across dark and light conditions in our eye tracking task. After excluding 12 participants, the average percent of trials successfully completed was 76.7 15.1 (average with ASD diagnosis = 72.7 15.6; average without ASD = 82.6 + / − 12.4; t(71) =  − 2.84, p = 0.002). Unusable trials were due to failure of tracking caused by child noncompliance (closing eyes or averting gaze away from screen) or recording failure during the task.
 
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Metagegevens
Titel
Resting and Functional Pupil Response Metrics Indicate Features of Reward Sensitivity and ASD in Children
Auteurs
Antoinette Sabatino DiCriscio
Vanessa Troiani
Publicatiedatum
25-09-2020
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-020-04721-y