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14-05-2019

Responsiveness of the EQ-5D-3L and EQ-5D-5L in patients following total hip or knee replacement

Tijdschrift:: Quality of Life Research

Auteurs:: Xuejing Jin, Fatima Al Sayah, Arto Ohinmaa, Deborah A. Marshall, Jeffrey A. Johnson

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Electronic supplementary material

The online version of this article (https://doi.org/10.1007/s11136-019-02200-1) contains supplementary material, which is available to authorized users.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Purpose

To examine the responsiveness of the EQ-5D-3L and EQ-5D-5L among total hip/knee replacement (THR/TKR) patients.

Methods

The EQ-5D (3L or 5L) and Western Ontario and McMaster University Osteoarthritis Index (WOMAC) have been routinely administered to all THR/TKR patients before and at 3 months after surgery in Alberta, Canada, since 2010. Patients were included in this analysis if they completed the WOMAC and the same version of EQ-5D at baseline and 3-month follow-up. The WOMAC was used as an anchor to categorize patients into 9 subgroups according to the relative change from baseline, i.e., no change, and 4 categories each for the amount of deterioration or improvement: large (≥ 70%), moderate (50% ≤ change < 70%), small but important (20% ≤ change < 50%), and very mild (0 < change ≤ 20%). The responsiveness of the EQ-5D-3L and EQ-5D-5L for each subgroup was assessed using effect size, standardized response mean, and Guyatt’s Responsiveness Index.

Results

A total of 1594 patients completed the EQ-5D-3L and WOMAC (60% females, mean age 66 years, N = 646 [41%] THR), and 3180 completed the EQ-5D-5L and WOMAC (60% females, mean age 66 years, N = 1352 [43.2%] THR) at baseline and 3-month follow-up. For both THR and TKR patients with “small but important” improvement, the EQ-5D-5L was consistently more responsive than the EQ-5D-3L.

Conclusion

Our study demonstrated that the EQ-5D-5L is more responsive than the EQ-5D-3L in identifying health-related quality of life changes in THR/TKR patients. We recommend using the EQ-5D-5L in longitudinal studies in this patient population.

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Supplementary material 1 (DOCX 21 kb)

11136_2019_2200_MOESM1_ESM.docx

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Titel: Responsiveness of the EQ-5D-3L and EQ-5D-5L in patients following total hip or knee replacement
Auteurs:: Xuejing Jin
Fatima Al Sayah
Arto Ohinmaa
Deborah A. Marshall
Jeffrey A. Johnson
Publicatiedatum: 14-05-2019
DOI: https://doi.org/10.1007/s11136-019-02200-1
Uitgeverij: Springer International Publishing
Tijdschrift: Quality of Life Research An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation - An Official Journal of the International Society of Quality of Life Research
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649

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