Skip to main content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Cognitive Therapy and Research 4/2010

01-08-2010 | Original Article

Reports of Childhood Physical Abuse, 5-HTTLPR Genotype, and Women’s Attentional Biases for Angry Faces

Auteurs: Ashley L. Johnson, Brandon E. Gibb, John McGeary

Gepubliceerd in: Cognitive Therapy and Research | Uitgave 4/2010

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

The goal of this study was to examine environmental (childhood physical abuse) and genetic (5-HTTLPR genotype) correlates of adult women’s attentional biases for facial displays of emotion. Supporting a gene × environment model of risk, women’s reports of childhood physical abuse were related to their attentional biases for angry faces among carriers of the 5-HTTLPR short allele, but not among those homozygous for the long allele. Specifically, women reporting a history of moderate to severe physical abuse who also carried at least one copy of the 5-HTTLPR short allele exhibited attentional avoidance of angry faces. These results were specific to angry faces and were not observed for happy or sad faces. Supporting the robustness of these findings, they were maintained even after statistically controlling for the influence of women’s lifetime diagnoses of major depression and anxiety disorders as well as their current symptoms of depression and anxiety, suggesting that the results were not due simply to current or past depression or anxiety.
Voetnoten
1
The similarity in effect size \( \left( {\eta_{p}^{2} } \right) \) in these analyses across the two genotype groups suggests the possibility that the nonsignificant result among women homozygous for the 5-HTTLPR long allele was due, in part, to the smaller size of this subsample. Given this, exploratory analyses were conducted to test for potential physical abuse group differences in attentional biases for the three facial expressions among these women. Among women homozygous for the 5-HTTLPR long allele, tests of simple main effects within Facial Expression type revealed no significant physical abuse differences for angry, F(1, 29) = 0.69, p = 0.41, \( \eta_{p}^{2} = 0.02 \), happy, F(1, 29) = 2.87, p = 0.10, \( \eta_{p}^{2} = 0.09 \), or sad, F(1, 29) = 0.11, p = 0.75, \( \eta_{p}^{2} = 0.00 4 \) faces.
 
2
Although not the primary focus of this study, we also examined whether women’s current or lifetime diagnoses of MDD and/or anxiety disorders were related to attentional biases for any of the facial expressions. None of these analyses was significant, nor did diagnostic status significantly interact with abuse history of 5-HTTLPR genotype to predict attentional biases.
 
Literatuur
go back to reference Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M. J., & vn IJzendoorn, M. H. (2007). Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study. Psychological Bulletin, 133, 1–24. CrossRefPubMed Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M. J., & vn IJzendoorn, M. H. (2007). Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study. Psychological Bulletin, 133, 1–24. CrossRefPubMed
go back to reference Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893–897. CrossRefPubMed Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology, 56, 893–897. CrossRefPubMed
go back to reference Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Beck depression inventory manual (2nd ed.). San Antonio, TX: Psychological Corporation. Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Beck depression inventory manual (2nd ed.). San Antonio, TX: Psychological Corporation.
go back to reference Beevers, C. G., & Carver, C. S. (2003). Attentional bias and mood persistence as prospective predictors of dysphoria. Cognitive Therapy and Research, 27, 619–637. CrossRef Beevers, C. G., & Carver, C. S. (2003). Attentional bias and mood persistence as prospective predictors of dysphoria. Cognitive Therapy and Research, 27, 619–637. CrossRef
go back to reference Beevers, C. G., Gibb, B. E., McGeary, J. E., & Miller, I. W. (2007). Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients. Journal of Abnormal Psychology, 116, 208–212. CrossRefPubMed Beevers, C. G., Gibb, B. E., McGeary, J. E., & Miller, I. W. (2007). Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients. Journal of Abnormal Psychology, 116, 208–212. CrossRefPubMed
go back to reference Bernstein, D. P., & Fink, L. (1998). Childhood trauma questionnaire: A retrospective self-report. San Antonio, TX: The Psychological Corporation. Bernstein, D. P., & Fink, L. (1998). Childhood trauma questionnaire: A retrospective self-report. San Antonio, TX: The Psychological Corporation.
go back to reference Bernstein, D. P., Stein, J. A., Newcomb, M. D., Walker, E., Pogge, D., Ahluvalia, T., et al. (2003). Development and validation of a brief screening version of the childhood trauma questionnaire. Child Abuse and Neglect, 27, 169–190. CrossRefPubMed Bernstein, D. P., Stein, J. A., Newcomb, M. D., Walker, E., Pogge, D., Ahluvalia, T., et al. (2003). Development and validation of a brief screening version of the childhood trauma questionnaire. Child Abuse and Neglect, 27, 169–190. CrossRefPubMed
go back to reference Bradley, R. G., Binder, E. B., Epstein, M. P., Tang, Y., Nair, H. P., Liu, W., et al. (2008). Influence of child abuse on adult depression: Moderation by the corticotropin-releasing hormone receptor gene. Archives of General Psychiatry, 65, 190–200. CrossRefPubMed Bradley, R. G., Binder, E. B., Epstein, M. P., Tang, Y., Nair, H. P., Liu, W., et al. (2008). Influence of child abuse on adult depression: Moderation by the corticotropin-releasing hormone receptor gene. Archives of General Psychiatry, 65, 190–200. CrossRefPubMed
go back to reference Brewin, C. R., Andrews, B., & Gotlib, I. H. (1993). Psychopathology and early experience: A reappraisal of retrospective reports. Psychological Bulletin, 113, 82–98. CrossRefPubMed Brewin, C. R., Andrews, B., & Gotlib, I. H. (1993). Psychopathology and early experience: A reappraisal of retrospective reports. Psychological Bulletin, 113, 82–98. CrossRefPubMed
go back to reference Cicchetti, D., Toth, S. L., & Maughan, A. (2000). An ecological-transactional model of child maltreatment. In A. J. Sameroff, M. Lewis, & S. M. Miller (Eds.), Handbook of developmental psychopathology (2nd ed., pp. 689–722). New York: Kluwer. Cicchetti, D., Toth, S. L., & Maughan, A. (2000). An ecological-transactional model of child maltreatment. In A. J. Sameroff, M. Lewis, & S. M. Miller (Eds.), Handbook of developmental psychopathology (2nd ed., pp. 689–722). New York: Kluwer.
go back to reference Clark, D. A., Beck, A. T., & Alford, B. A. (1999). Scientific foundations of cognitive theory and therapy of depression. New Jersey: Wiley. Clark, D. A., Beck, A. T., & Alford, B. A. (1999). Scientific foundations of cognitive theory and therapy of depression. New Jersey: Wiley.
go back to reference Clarke, P., MacLeod, C., & Shirazee, N. (2008). Prepared for the worst: Readiness to acquire threat bias and susceptibility to elevate trait anxiety. Emotion, 8, 47–57. CrossRefPubMed Clarke, P., MacLeod, C., & Shirazee, N. (2008). Prepared for the worst: Readiness to acquire threat bias and susceptibility to elevate trait anxiety. Emotion, 8, 47–57. CrossRefPubMed
go back to reference Creamer, M., Foran, J., & Bell, R. (1995). The beck anxiety inventory in a non-clinical sample. Behaviour Research and Therapy, 33, 477–485. CrossRefPubMed Creamer, M., Foran, J., & Bell, R. (1995). The beck anxiety inventory in a non-clinical sample. Behaviour Research and Therapy, 33, 477–485. CrossRefPubMed
go back to reference Crick, N. R., & Dodge, K. A. (1994). A review and reformulation of social information-processing mechanisms in children’s social adjustment. Psychological Bulletin, 115, 74–101. CrossRef Crick, N. R., & Dodge, K. A. (1994). A review and reformulation of social information-processing mechanisms in children’s social adjustment. Psychological Bulletin, 115, 74–101. CrossRef
go back to reference Endicott, J., & Spitzer, R. L. (1978). A diagnostic interview: The schedule for affective disorders and schizophrenia. Archives of General Psychiatry, 35, 837–844. PubMed Endicott, J., & Spitzer, R. L. (1978). A diagnostic interview: The schedule for affective disorders and schizophrenia. Archives of General Psychiatry, 35, 837–844. PubMed
go back to reference Freeman, B., Powell, J., Ball, D., Hill, L., Craig, I., & Plomin, R. (1997). DNA by mail: An inexpensive and noninvasive method for collecting DNA samples from widely dispersed populations. Behavior Genetics, 27, 251–257. CrossRefPubMed Freeman, B., Powell, J., Ball, D., Hill, L., Craig, I., & Plomin, R. (1997). DNA by mail: An inexpensive and noninvasive method for collecting DNA samples from widely dispersed populations. Behavior Genetics, 27, 251–257. CrossRefPubMed
go back to reference Gibb, B. E., & Abela, J. R. Z. (2008). Emotional abuse, verbal victimization, and the development of children’s negative inferential styles and depressive symptoms. Cognitive Therapy and Research, 32, 161–176. CrossRef Gibb, B. E., & Abela, J. R. Z. (2008). Emotional abuse, verbal victimization, and the development of children’s negative inferential styles and depressive symptoms. Cognitive Therapy and Research, 32, 161–176. CrossRef
go back to reference Gibb, B. E., & Alloy, L. B. (2006). A prospective test of the hopelessness theory of depression in children. Journal of Clinical Child and Adolescent Psychology, 35, 264–274. CrossRefPubMed Gibb, B. E., & Alloy, L. B. (2006). A prospective test of the hopelessness theory of depression in children. Journal of Clinical Child and Adolescent Psychology, 35, 264–274. CrossRefPubMed
go back to reference Gibb, B. E., Benas, J. S., Grassia, M., & McGeary, J. (2009a). Children’s attentional biases and 5-HTTLPR genotype: Potential mechanisms linking mother and child depression. Journal of Clinical Child and Adolescent Psychology, 38, 415–426. CrossRefPubMed Gibb, B. E., Benas, J. S., Grassia, M., & McGeary, J. (2009a). Children’s attentional biases and 5-HTTLPR genotype: Potential mechanisms linking mother and child depression. Journal of Clinical Child and Adolescent Psychology, 38, 415–426. CrossRefPubMed
go back to reference Gibb, B. E., Johnson, A. L., Benas, J. S., Uhrlass, D. J., & McGeary, J. (2009b). Children’s 5-HTTLPR genotype moderates the link between maternal criticism and attentional biases specifically for facial displays of anger. Manuscript submitted for publication. Gibb, B. E., Johnson, A. L., Benas, J. S., Uhrlass, D. J., & McGeary, J. (2009b). Children’s 5-HTTLPR genotype moderates the link between maternal criticism and attentional biases specifically for facial displays of anger. Manuscript submitted for publication.
go back to reference Gibb, B. E., Schofield, C. A., & Coles, M. E. (2009c). Reported history of childhood abuse and young adults’ information processing biases for facial displays of emotion. Child Maltreatment, 14, 148–156. CrossRefPubMed Gibb, B. E., Schofield, C. A., & Coles, M. E. (2009c). Reported history of childhood abuse and young adults’ information processing biases for facial displays of emotion. Child Maltreatment, 14, 148–156. CrossRefPubMed
go back to reference Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008). HPA axis reactivity: A mechanism underlying the associations among 5-HTTLPR stress, and depression. Biological Psychiatry, 63, 847–851. CrossRefPubMed Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008). HPA axis reactivity: A mechanism underlying the associations among 5-HTTLPR stress, and depression. Biological Psychiatry, 63, 847–851. CrossRefPubMed
go back to reference Gotlib, I. H., & MacLeod, C. (1997). Information processing in anxiety and depression: A cognitive-developmental perspective. In J. A. Burack & J. T. Enns (Eds.), Attention, development, and psychopathology (pp. 350–378). New York: Guilford. Gotlib, I. H., & MacLeod, C. (1997). Information processing in anxiety and depression: A cognitive-developmental perspective. In J. A. Burack & J. T. Enns (Eds.), Attention, development, and psychopathology (pp. 350–378). New York: Guilford.
go back to reference Joormann, J. (2008). Cognitive aspects of depression. In I. H. Gotlib & C. L. Hammen (Eds.), Handbook of depression (2nd ed., pp. 298–321). New York: Guilford. Joormann, J. (2008). Cognitive aspects of depression. In I. H. Gotlib & C. L. Hammen (Eds.), Handbook of depression (2nd ed., pp. 298–321). New York: Guilford.
go back to reference Joormann, J., & Gotlib, I. (2007). Selective attention to emotional faces following recovery from depression. Journal of Abnormal Psychology, 116, 80–85. CrossRefPubMed Joormann, J., & Gotlib, I. (2007). Selective attention to emotional faces following recovery from depression. Journal of Abnormal Psychology, 116, 80–85. CrossRefPubMed
go back to reference Kaufman, J., Yang, B., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., et al. (2006). Brain-derived neurotrophic factor-5-HHTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry, 59, 673–680. CrossRefPubMed Kaufman, J., Yang, B., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., et al. (2006). Brain-derived neurotrophic factor-5-HHTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry, 59, 673–680. CrossRefPubMed
go back to reference Koenen, K. C. (2007). Genetics of posttraumatic stress disorder: Review and recommendations for future studies. Journal of Traumatic Stress, 20, 737–750. CrossRefPubMed Koenen, K. C. (2007). Genetics of posttraumatic stress disorder: Review and recommendations for future studies. Journal of Traumatic Stress, 20, 737–750. CrossRefPubMed
go back to reference Lench, N., Stanier, P., & Williamson, R. (1988). Simple non-invasive method to obtain DNA for gene analysis. Lancet, 1, 1356–1358. CrossRefPubMed Lench, N., Stanier, P., & Williamson, R. (1988). Simple non-invasive method to obtain DNA for gene analysis. Lancet, 1, 1356–1358. CrossRefPubMed
go back to reference MacLeod, C., Koster, E. H., & Fox, E. (2009). Whither cognitive bias modification research? Commentary on the special section articles. Journal of Abnormal Psychology, 118(1), 89–99. CrossRefPubMed MacLeod, C., Koster, E. H., & Fox, E. (2009). Whither cognitive bias modification research? Commentary on the special section articles. Journal of Abnormal Psychology, 118(1), 89–99. CrossRefPubMed
go back to reference MacLeod, C., Mathews, A., & Tata, P. (1986). Attentional bias in emotional disorders. Journal of Abnormal Psychology, 95, 15–20. CrossRefPubMed MacLeod, C., Mathews, A., & Tata, P. (1986). Attentional bias in emotional disorders. Journal of Abnormal Psychology, 95, 15–20. CrossRefPubMed
go back to reference MacLeod, C., Rutherford, E., Campbell, L., Ebsworthy, G., & Holker, L. (2002). Selective attention and emotional vulnerability: Assessing the causal basis of their association through the experimental manipulation of attentional bias. Journal of Abnormal Psychology, 111(1), 107–123. CrossRefPubMed MacLeod, C., Rutherford, E., Campbell, L., Ebsworthy, G., & Holker, L. (2002). Selective attention and emotional vulnerability: Assessing the causal basis of their association through the experimental manipulation of attentional bias. Journal of Abnormal Psychology, 111(1), 107–123. CrossRefPubMed
go back to reference Mathews, A., & MacLeod, C. (2002). Induced processing biases have causal effects on anxiety. Cognition & Emotion, 16(3), 331–354. CrossRef Mathews, A., & MacLeod, C. (2002). Induced processing biases have causal effects on anxiety. Cognition & Emotion, 16(3), 331–354. CrossRef
go back to reference Mathews, A., & MacLeod, C. (2005). Cognitive vulnerability to emotional disorders. Annual Review of Clinical Psychology, 1, 167–195. CrossRefPubMed Mathews, A., & MacLeod, C. (2005). Cognitive vulnerability to emotional disorders. Annual Review of Clinical Psychology, 1, 167–195. CrossRefPubMed
go back to reference Mogg, K., Bradley, B. P., & Williams, R. (1995). Attentional bias in anxiety and depression: The role of awareness. British Journal of Clinical Psychology, 34, 17–36. PubMed Mogg, K., Bradley, B. P., & Williams, R. (1995). Attentional bias in anxiety and depression: The role of awareness. British Journal of Clinical Psychology, 34, 17–36. PubMed
go back to reference Munafó, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63, 852–857. CrossRefPubMed Munafó, M. R., Brown, S. M., & Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry, 63, 852–857. CrossRefPubMed
go back to reference Persons, J. J., & Miranda, J. (1992). Cognitive theories of vulnerability to depression: Reconciling negative evidence. Cognitive Therapy and Research, 16, 485–502. CrossRef Persons, J. J., & Miranda, J. (1992). Cognitive theories of vulnerability to depression: Reconciling negative evidence. Cognitive Therapy and Research, 16, 485–502. CrossRef
go back to reference Pine, D. S., Mogg, K., Bradley, B. P., Montgomery, L., Monk, C. S., McClure, E., et al. (2005). Attention bias to threat in maltreated children: Implications for vulnerability to stress-related psychopathology. American Journal of Psychiatry, 162, 291–296. CrossRefPubMed Pine, D. S., Mogg, K., Bradley, B. P., Montgomery, L., Monk, C. S., McClure, E., et al. (2005). Attention bias to threat in maltreated children: Implications for vulnerability to stress-related psychopathology. American Journal of Psychiatry, 162, 291–296. CrossRefPubMed
go back to reference Pollak, S. D. (2003). Experience-dependent affective learning and risk for psychopathology in children. Annals of the New York Academy of Sciences, 1008, 102–111. CrossRefPubMed Pollak, S. D. (2003). Experience-dependent affective learning and risk for psychopathology in children. Annals of the New York Academy of Sciences, 1008, 102–111. CrossRefPubMed
go back to reference Pollak, S. D., & Tolley-Schell, S. A. (2003). Selective attention to facial emotion in physically abused children. Journal of Abnormal Psychology, 112, 323–338. CrossRefPubMed Pollak, S. D., & Tolley-Schell, S. A. (2003). Selective attention to facial emotion in physically abused children. Journal of Abnormal Psychology, 112, 323–338. CrossRefPubMed
go back to reference Pooley, E. C., Houston, K., Hawton, K., & Harrison, P. J. (2003). Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other sertonergic genes. Psychological Medicine, 33, 775–783. CrossRefPubMed Pooley, E. C., Houston, K., Hawton, K., & Harrison, P. J. (2003). Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other sertonergic genes. Psychological Medicine, 33, 775–783. CrossRefPubMed
go back to reference Psychological Software Tools. (2002). E-Prime (Version 1.1). [Computer software]. Pittsburgh, PA: Author. Psychological Software Tools. (2002). E-Prime (Version 1.1). [Computer software]. Pittsburgh, PA: Author.
go back to reference Rose, D. T., & Abramson, L. Y. (1992). Developmental predictors of depressive cognitive style: Research and theory. In D. Cicchetti & S. Toth (Eds.), Rochester symposium of developmental psychopathology (Vol. IV, pp. 323–349). Rochester, NY: University of Rochester Press. Rose, D. T., & Abramson, L. Y. (1992). Developmental predictors of depressive cognitive style: Research and theory. In D. Cicchetti & S. Toth (Eds.), Rochester symposium of developmental psychopathology (Vol. IV, pp. 323–349). Rochester, NY: University of Rochester Press.
go back to reference Rutter, M., Moffitt, T. E., & Caspi, A. (2006). Gene-environment interplay and psychopathology: Multiple varieties but real effects. Journal of Child Psychology and Psychiatry, 47, 226–261. CrossRefPubMed Rutter, M., Moffitt, T. E., & Caspi, A. (2006). Gene-environment interplay and psychopathology: Multiple varieties but real effects. Journal of Child Psychology and Psychiatry, 47, 226–261. CrossRefPubMed
go back to reference Shackman, J. E., Shackman, A. J., & Pollak, S. D. (2007). Physical abuse amplifies attention to threat and increases anxiety in children. Emotion, 7, 838–852. CrossRefPubMed Shackman, J. E., Shackman, A. J., & Pollak, S. D. (2007). Physical abuse amplifies attention to threat and increases anxiety in children. Emotion, 7, 838–852. CrossRefPubMed
go back to reference Tottenham, N., Tanaka, J. W., Leon, A. C., McCarry, T., Nurse, M., Hare, T. A., et al. (2008). The NimStim set of facial expressions: Judgments from untrained research participants. Psychiatry Research, 168, 242–249. Tottenham, N., Tanaka, J. W., Leon, A. C., McCarry, T., Nurse, M., Hare, T. A., et al. (2008). The NimStim set of facial expressions: Judgments from untrained research participants. Psychiatry Research, 168, 242–249.
go back to reference Uher, R., & McGuffin, P. (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodology analysis. Molecular Psychiatry, 13, 131–146. CrossRefPubMed Uher, R., & McGuffin, P. (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodology analysis. Molecular Psychiatry, 13, 131–146. CrossRefPubMed
go back to reference Widom, C. S., Czaja, S. J., & Dutton, M. A. (2008). Childhood victimization and lifetime revictimization. Child Abuse and Neglect, 32, 785–796. CrossRefPubMed Widom, C. S., Czaja, S. J., & Dutton, M. A. (2008). Childhood victimization and lifetime revictimization. Child Abuse and Neglect, 32, 785–796. CrossRefPubMed
go back to reference Williams, J. M. G., Watts, F. N., MacLeod, C., & Mathews, A. (1997). Cognitive psychology and emotional disorders. Oxford, England: Wiley. Williams, J. M. G., Watts, F. N., MacLeod, C., & Mathews, A. (1997). Cognitive psychology and emotional disorders. Oxford, England: Wiley.
Metagegevens
Titel
Reports of Childhood Physical Abuse, 5-HTTLPR Genotype, and Women’s Attentional Biases for Angry Faces
Auteurs
Ashley L. Johnson
Brandon E. Gibb
John McGeary
Publicatiedatum
01-08-2010
Uitgeverij
Springer US
Gepubliceerd in
Cognitive Therapy and Research / Uitgave 4/2010
Print ISSN: 0147-5916
Elektronisch ISSN: 1573-2819
DOI
https://doi.org/10.1007/s10608-009-9269-3

Andere artikelen Uitgave 4/2010

Cognitive Therapy and Research 4/2010 Naar de uitgave