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Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2006

01-08-2006 | Letter

Report of Altered Urinary Oxytocin and AVP Excretion in Neglected Orphans should be Reconsidered

Auteur: George M. Anderson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2006

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Excerpt

The closely related centrally and peripherally acting nonapeptides, oxytocin and arginine vasopressin (AVP), have been suggested to be involved in the neurobiology of autism (Green et al., 2001; Insel, 1997; Insel, O'Brien, & Leckman, 1999; Modahl, Fein, Waterhouse, & Newton, 1992; Panksepp, 1993). Hypotheses in this realm have been prompted by the role of the neuropeptides in mating, affiliation, attachment, maternal and approach behaviors in animals (Bielsky, Hu, Szegda, Westphal, & Young, 2004; Carter, 1998; Leckman & Herman, 2002; Lim, Bielsky, & Young, 2005; Winslow & Insel, 2002; Young, Pitkow, & Ferguson, 2002). A recent study reporting positive effects of oxytocin administration on levels of trust behavior in humans has further increased interest in the possible role of oxytocin and related compounds in human affiliation and social relatedness (Damasio, 2005; Kosfeld, Heinrichs, Zak, Fischbacher, & Fehr, 2005). Although definitve and replicated neurbiological and genetic data supporting a role for either peptide in autism are lacking, additional research in this general area is clearly justified. …
Voetnoten
1
A compilation of prior studies of human urinary oxytocin and AVP is available from the author: george.anderson@yale.edu
 
2
pg or picogram, 10−12, one trillionth of a gram; µg or microgram, 10−6, one millionth of a gram
 
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Metagegevens
Titel
Report of Altered Urinary Oxytocin and AVP Excretion in Neglected Orphans should be Reconsidered
Auteur
George M. Anderson
Publicatiedatum
01-08-2006
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2006
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-006-0153-7

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