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12-06-2017 | Heart Beat | Uitgave 10/2017 Open Access

Netherlands Heart Journal 10/2017

Renal denervation as a treatment strategy for vasospastic angina induced ventricular tachycardia

Netherlands Heart Journal > Uitgave 10/2017
L. Feyz, S. Wijchers, J. Daemen
Polymorphic ventricular tachycardia can be a detrimental consequence of coronary vasospasm [ 1]. The pathophysiology of vasospastic angina (VA) is poorly understood, although the disease has been linked to sympathetic hyperactivity [ 24]. We present a 52-year-old male smoker with ventricular fibrillation (VF) 2 years ago. Work-up revealed no signs of structural heart disease or obstructive coronary disease. We implanted an implantable cardioverter defibrillator (ICD). Several episodes of non-sustained polymorphic ventricular tachycardia and ICD shocks due to VF ensued, despite maintenance therapy with isosorbide 100 mg, metoprolol 50 mg, verapamil 300 mg, amiodarone 200 mg. Methylergometrine testing confirmed VA as the cause of VF (Fig.  1a,b). To reduce sympathetic hyperactivity, bilateral renal denervation was performed using the ReCor Paradise system. The patient remained free from episodes of angina and ventricular arrhythmias at 6 and 12 months. Ambulatory blood pressure and mean heart rate remained stable between baseline and 6 months (108/60 mm Hg vs. 113/71 mm Hg and 60 bpm vs. 60 bpm, respectively). Renal denervation could be a safe and effective treatment for normotensive patients with severe VA despite optimal medical therapy.

Conflict of interest

L. Feyz, S. Wijchers and J. Daemen declare that they have no competing interests. The Erasmus Medical Center received institutional research support from Boston Scientific, St. Jude Medical, Medtronic, ReCor Medical, Acist Medical.
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Netherlands Heart Journal

Het Netherlands Heart Journal wordt uitgegeven in samenwerking met de Nederlandse Vereniging voor Cardiologie en de Nederlandse Hartstichting. Het tijdschrift is Engelstalig en wordt gratis beschikbaa ...

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