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24-01-2023

Reliability and validity of the Chinese version of chronic liver disease questionnaire-nonalcoholic fatty liver disease in patients with nonalcoholic fatty liver disease: a multicenter cross-sectional survey in China

Auteurs: Rui Huang, Jian-Gao Fan, Jun-Ping Shi, Yi-Min Mao, Bing-Yuan Wang, Jing-Min Zhao, Lun-Gen Lu, Bi-Hui Zhong, Zheng-Sheng Zou, You-Qing Xu, Yi-Nong Ye, Long-Gen Liu, Lian-Jie Lin, Hui-Ying Rao, Lai Wei

Gepubliceerd in: Quality of Life Research | Uitgave 3/2023

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Abstract

Purpose

The Chronic Liver Disease Questionnaire (CLDQ)-Nonalcoholic Fatty Liver Disease (NAFLD) is a disease-specific instrument to assess the health-related quality of life (HRQL) of patients with NAFLD. In order to provide further evidence for the cross-cultural utility of this instrument in the Chinese population, we translated the CLDQ-NAFLD into Chinese and examined its reliability and validity.

Methods

Patients with NAFLD in 90 hospitals across China were enrolled in this multicenter cross-sectional survey. Eligible patients completed the Chinese version of CLDQ-NAFLD at enrollment to assess HRQL. Internal consistency of the questionnaire was assessed using Cronbach’s alpha coefficient and split-half reliability. Convergent and discriminant validity were assessed using Spearman correlation coefficient. Factor analysis was used to test the construct validity.

Results

Between March and August 2019, 5181 patients with a mean age of 43.8 ± 13.3 years were enrolled. All domains exhibited good internal consistency, with Cronbach’s alpha and split-half reliability greater than 0.70. The scaling success rate of all domains was 100% for convergent validity and 99.4% (179/180) for discriminant validity. The inter-scale correlations indicated a significant correlation between all CLDQ-NAFLD domains (r = 0.608 to 0.832, all p < 0.001). Factor analysis of 36 items extracted 6 factors, which explained 69.14% of the total variance.

Conclusion

The Chinese version of CLDQ-NAFLD is a reliable and valid instrument for assessing the HRQL of Chinese patients with NAFLD.
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Metagegevens
Titel
Reliability and validity of the Chinese version of chronic liver disease questionnaire-nonalcoholic fatty liver disease in patients with nonalcoholic fatty liver disease: a multicenter cross-sectional survey in China
Auteurs
Rui Huang
Jian-Gao Fan
Jun-Ping Shi
Yi-Min Mao
Bing-Yuan Wang
Jing-Min Zhao
Lun-Gen Lu
Bi-Hui Zhong
Zheng-Sheng Zou
You-Qing Xu
Yi-Nong Ye
Long-Gen Liu
Lian-Jie Lin
Hui-Ying Rao
Lai Wei
Publicatiedatum
24-01-2023
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 3/2023
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-022-03305-w

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