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01-09-2012 | Brief Communication | Uitgave 7/2012

Quality of Life Research 7/2012

Reliability and validity of PDQ-39: a quality-of-life measure for patients with PD in China

Quality of Life Research > Uitgave 7/2012
Jing-Lin Zhang, Piu Chan


The syndromes of Parkinson’s disease (PD) have impacts on health-related quality of life (HRQL). The 39-item Parkinson’s disease Questionnaire (PDQ-39) was the first specific and a consistent instrument for the evaluation of HRQL in PD patients.


To test the reliability and validity of Chinese version PDQ-39.


Hundred and twenty-six PD without cognitive impairment were enrolled. The Chinese version of SF-36 was used to evaluate the congruent validity of PDQ-39 between related domains. Both PDQ-39 and SF-36 scales were fulfilled by the patients themselves.


Five of eight subscales of PDQ-39 met the acceptable standards of reliability (Cronbach’s α coefficient >0.80), while the other three subscales (cognition, communication, and bodily discomfort) failed to reach the above standards as reported by the others. All the item-to-subscale correlations (range: 0.457–0.887) met the minimal acceptable item convergent validity criterion of 0.40 (P < 0.001). Correlation between PDQ-39 subscales and scales of the SF-36 had high negative correlations with a range of −0.759 to −0.124. Four of them had significant negative correlations (P < 0.0001).


The Chinese version of PDQ-39 is a reliable and valid instrument for Chinese PD patients. It is recommended as the most appropriate HRQL tool for PD.

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