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Research on Child and Adolescent Psychopathology

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01-04-2013

Relational Security Moderates the Effect of Serotonin Transporter Gene Polymorphism (5-HTTLPR) on Stress Generation and Depression among Adolescents

Auteurs: Lisa R. Starr, Constance Hammen, Patricia A. Brennan, Jake M. Najman

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 3/2013

Abstract

Previous research demonstrates that carriers of the short allele of the serotonin transporter gene (5-HTTLPR) show both greater susceptibility to depression in response to stressful life events and higher rates of generation of stressful events in response to depression. The current study examines relational security (i.e., self-reported beliefs about attachment security) as a moderator of these effects, building on emerging research suggesting that the short allele acts as a marker of sensitivity to the social environment. Participants were 354 Caucasian adolescents oversampled for maternal depression (137 male, 217 female), assessed at ages 15 and 20. Results indicated that the short allele predicted increased stress generation at age 20 among those with low age 15 security but decreased stress generation among those with high security, and revealed a three-way interaction between age 15 depression, age 15 security, and genotype, where depression predicted stress generation only among short allele carriers with low security. Further, among boys only, security interacted with genotype to predict longitudinal changes in depression diagnosis, with the s-allele predicting relative increases in probability of depression among boys with low security but decreases among boys with high security. Results support the notion of the short allele as a marker of social reactivity, and suggest that attachment security may buffer against the genetic vulnerability introduced by the short allele, in line with predictions of the differential susceptibility theory.

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Aiken, L. S., & West, S. G. (1991). Multiple regression: Testing and interpreting interactions. Thousand Oaks: Sage Publications, Inc.

Araya, R., Hu, X., Heron, J., Enoch, M.-A., Evans, J., Lewis, G., et al. (2009). Effects of stressful life events, maternal depression and 5-HTTLPR genotype on emotional symptoms in pre-adolescent children. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 150B, 670–682. doi:10.1002/ajmg.b.30888.CrossRef

Barry, R. A., Kochanska, G., & Philibert, R. A. (2008). G × E interaction in the organization of attachment: mothers’ responsiveness as a moderator of children’s genotypes. Journal of Child Psychology and Psychiatry, 49, 1313–1320. doi:10.1111/j.1469-7610.2008.01935.x.PubMedCrossRef

Bartholomew, K. (1998). The Family and Peer Attachment Interview. Unpublished manuscript. Simon Fraser University.

Bartholomew, K., & Horowitz, L. M. (1991). Attachment styles among young adults: a test of a four-category model. Journal of Personality and Social Psychology; Journal of Personality and Social Psychology, 61, 226.CrossRef

Bartholomew, K., & Shaver, P. R. (1998). Methods of assessing adult attachment: Do they converge? In J. A. Simpson & W. S. Rholes (Eds.), Attachment theory and close relationship (pp. 25–45). New York: Gyukfird Press.

Beck, A. T., Steer, R. A., & Garbin, M. G. (1988). Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clinical Psychology Review, 8, 77–100.CrossRef

Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Manual for the Beck depression inventory-II (pp. 1–82). San Antonio: Psychological Corporation.

Bedford, A., & Foulds, G. (1978). Delusions-Symptoms-States Inventory of Anxiety and Depression. Windsor: NFER.

Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: differential susceptibility to environmental influences. Psychological Bulletin, 135, 885.PubMedCrossRef

Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). For better and for worse. Current Directions in Psychological Science, 16, 300–304. doi:10.1111/j.1467-8721.2007.00525.x.CrossRef

Bottonari, K. A., Roberts, J. E., Kelly, M. A. R., Kashdan, T. B., & Ciesla, J. A. (2007). A prospective investigation of the impact of attachment style on stress generation among clinically depressed individuals. Behaviour Research and Therapy, 45, 179–188. doi:10.1016/j.brat.2006.01.003.PubMedCrossRef

Bowlby, J. (1969). Attachment and loss: Vol.1. Attachment. New York: Basic Books.

Bowlby, J. (1980). Attachment and loss. New York: Basic Books.

Brown, G. W., & Harris, T. (1978). Social Origins of Depression.

Brummett, B. H., Boyle, S. H., Siegler, I. C., Kuhn, C. M., Ashley-Koch, A., Jonassaint, C. R., et al. (2008). Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behavior Genetics, 38, 34–43.PubMedCrossRef

Brussoni, M. J., Jang, K. L., Livesley, W. J., & Macbeth, T. M. (2000). Genetic and environmental influences on adult attachment styles. Personal Relationships, 7, 283–289. doi:10.1111/j.1475-6811.2000.tb00017.x.CrossRef

Caspers, K. M., Paradiso, S., Yucuis, R., Troutman, B., Arndt, S., & Philibert, R. (2009). Association between the serotonin transporter promoter polymorphism (5-HTTLPR) and adult unresolved attachment. Developmental Psychology, 45, 64.PubMedCrossRef

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389. doi:10.1126/science.1083968.PubMedCrossRef

Collins, N. L., & Read, S. J. (1990). Adult attachment, working models, and relationship quality in dating couples. Journal of Personality and Social Psychology, 58, 644.PubMedCrossRef

Davila, J., Steinberg, S. J., Kachadourian, L., Cobb, R., & Fincham, F. (2004). Romantic involvement and depressive symptoms in early and late adolescence: the role of a preoccupied relational style. Personal Relationships, 11, 161–178.CrossRef

Davila, J., Ramsay, M., Stroud, C. B., & Steinberg, S. J. (2005). Attachment as vulnerability to the development of psychopathology. In B. L. Hankin & J. R. Z. Abela (Eds.), Development of psychopathology: A vulnerability-stress perspective (pp. 215–242). Thousand Oaks: Sage.CrossRef

Du, L., Bakish, D., & Hrdina, P. D. (2000). Gender differences in association between serotonin transporter gene polymorphism and personality traits. Psychiatric Genetics, 10, 159.PubMedCrossRef

Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., et al. (2004). Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, 908–915.PubMedCrossRef

Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: an evolutionary neurodevelopmental theory. Development and Psychopathology, 23, 7–28. doi:10.1017/S0954579410000611.PubMedCrossRef

George, C., Kaplan, N., & Main, M. (1985). The berkeley adult attachment interview. Berkeley: Department of Psychology. University of California, Berkeley.

Gilissen, R., Bakermans-Kranenburg, M. J., van IJzendoorn, M. H., & Linting, M. (2008). Electrodermal reactivity during the Trier Social Stress Test for children: interaction between the serotonin transporter polymorphism and children’s attachment representation. Developmental Psychobiology, 50, 615–625. doi:10.1002/dev.20314.PubMedCrossRef

Gillath, O., Shaver, P. R., Baek, J.-M., & Chun, D. S. (2008). Genetic correlates of adult attachment style. Personality and Social Psychology Bulletin, 34, 1396–1405. doi:10.1177/0146167208321484.PubMedCrossRef

Grabe, H. J., Lange, M., Wolff, B., Volzke, H., Lucht, M., Freyberger, H. J., et al. (2004). Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Molecular Psychiatry, 10, 220–224.CrossRef

Griffin, D. W., & Bartholomew, K. (1994). Models of the self and other: fundamental dimensions underlying measures of adult attachment. Journal of Personality and Social Psychology, 67, 430.CrossRef

Hammen, C. (1991). Generation of stress in the course of unipolar depression. Journal of Abnormal Psychology, 100, 555.PubMedCrossRef

Hammen, C. (2006). Stress generation in depression: reflections on origins, research, and future directions. Journal of Clinical Psychology, 62, 1065–1082. doi:10.1002/jclp. 20293.PubMedCrossRef

Hammen, C., Henry, R., & Daley, S. E. (2000). Depression and sensitization to stressors among young women as a function of childhood adversity. Journal of Consulting and Clinical Psychology, 68, 782–787.PubMedCrossRef

Hammen, C., Brennan, P. A., Keenan-Miller, D., Hazel, N. A., & Najman, J. M. (2010). Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth. Journal of Child Psychology and Psychiatry, 51, 180–187. doi:10.1111/j.1469-7610.2009.02177.x.PubMedCrossRef

Hankin, B. L., Kassel, J. D., & Abela, J. R. Z. (2005). Adult attachment dimensions and specificity of emotional distress symptoms: prospective investigations of cognitive risk and interpersonal stress generation as mediating mechanisms. Personality and Social Psychology Bulletin, 31, 136–151. doi:10.1177/0146167204271324.PubMedCrossRef

Hankin, B. L., Nederhof, E., Oppenheimer, C. W., Jenness, J., Young, J. F., Abela, J. R. Z., et al. (2011). Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect ‘for better and worse’. Translational Psychiatry, 1, e44.PubMedCrossRef

Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Archives of General Psychiatry, 68, 444–454. doi:10.1001/archgenpsychiatry.2010.189.PubMedCrossRef

Kaufman, J., Birmaher, B., Brent, D., & Rao, U. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 980–988.PubMedCrossRef

Kaufman, J., Yang, B.-Z., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., Krystal, J. H., et al. (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences of the United States of America, 101, 17316–17321. doi:10.1073/pnas.0404376101.PubMedCrossRef

Keenan-Miller, D., Hammen, C. L., & Brennan, P. A. (2007). Health outcomes related to early adolescent depression. Journal of Adolescent Health, 41, 256–262.PubMedCrossRef

Keeping, J. D., Najman, J. M., Morrison, J., Western, J. S., Anderson, M. J., & Williams, G. M. (1989). A prospective longitudinal study of social, psychological, and obstetrical factors in pregnancy: response rates and demographic characteristics of the 8,556 respondents. British Journal of Obstetrics and Gynaecology, 96, 289–297.PubMedCrossRef

Kendler, K. S., Kuhn, J. W., Vittum, J., Prescott, C. A., & Riley, B. (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Archives of General Psychiatry, 62, 529–535.PubMedCrossRef

Kilpatrick, D. G., Koenen, K. C., Ruggiero, K. J., Acierno, R., Galea, S., Resnick, H. S., et al. (2007). The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults. The American Journal of Psychiatry, 164, 1693–1699. doi:10.1176/appi.ajp. 2007.06122007.PubMedCrossRef

Lewinsohn, P. M., Clarke, G. N., Seeley, J. R., & Rohde, P. (1994). Major depression in community adolescents: age at onset, episode duration, and time to recurrence. Journal of the American Academy of Child and Adolescent Psychiatry, 33, 809–818.PubMedCrossRef

Liu, R. T., & Alloy, L. B. (2010). Stress generation in depression: a systematic review of the empirical literature and recommendations for future study. Clinical Psychology Review, 30, 582–593. doi:10.1016/j.cpr.2010.04.010.PubMedCrossRef

Luijk, M. P. C. M., Roisman, G. I., Haltigan, J. D., Tiemeier, H., Booth-LaForce, C., van IJzendoorn, M. H., et al. (2011). Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects. Journal of Child Psychology and Psychiatry, 52, 1295–1307. doi:10.1111/j.1469-7610.2011.02440.x.PubMedCrossRef

Monroe, S. M., & Simons, A. D. (1991). Diathesis-stress theories in the context of life stress research: implications for the depressive disorders. Psychological Bulletin, 110, 406.PubMedCrossRef

Nakatani, D., Sato, H., Sakata, Y., Shiotani, I., Kinjo, K., Mizuno, H., et al. (2005). Influence of serotonin transporter gene polymorphism on depressive symptoms and new cardiac events after acute myocardial infarction. American Heart Journal, 150, 652–658. doi:10.1016/j.ahj.2005.03.062.PubMedCrossRef

Noftle, E. E., & Shaver, P. R. (2006). Attachment dimensions and the big five personality traits: associations and comparative ability to predict relationship quality. Journal of Research in Personality, 40, 179–208. doi:10.1016/j.jrp. 2004.11.003.CrossRef

Nolen-Hoeksema, S., & Girgus, J. S. (1994). The emergence of gender differences in depression during adolescence. Psychological Bulletin, 115, 424–443.PubMedCrossRef

Nolen-Hoeksema, S., Larson, J., & Grayson, C. (1999). Explaining the gender difference in depressive symptoms. Journal of Personality and Social Psychology, 77, 1061–1072.PubMedCrossRef

Ognibene, T. C., & Collins, N. L. (1998). Adult attachment styles, perceived social support and coping strategies. Journal of Social and Personal Relationships, 15, 323–345. doi:10.1177/0265407598153002.CrossRef

Orvaschel, H. (1995). Schedule for Affective Disorders and Schizophrenia for School-Age Children: Epidemiologic Version-5. Fort Lauderdale: Nova Southeastern University, Center for Psychological Studies.

Pluess, M., Belsky, J., Way, B. M., & Taylor, S. E. (2010). 5-HTTLPR moderates effects of current life events on neuroticism: differential susceptibility to environmental influences. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34, 1070–1074. doi:10.1016/j.pnpbp. 2010.05.028.CrossRef

Prinstein, M. J., Borelli, J. L., Cheah, C. S. L., Simon, V. A., & Aikins, J. W. (2005). Adolescent girls’ interpersonal vulnerability to depressive symptoms: a longitudinal examination of reassurance-seeking and peer relationships. Journal of Abnormal Psychology, 114, 676–688.PubMedCrossRef

Reiner, I., & Spangler, G. (2010). Adult attachment and gene polymorphisms of the dopamine d4 receptor and serotonin transporter (5-HTT). Attachment & Human Development, 12, 209–229. doi:10.1080/14616731003759674.CrossRef

Rudolph, K. D. (2002). Gender differences in emotional responses to interpersonal stress during adolescence. Journal of Adolescent Health, 30, 3–13.PubMedCrossRef

Rudolph, K. D., & Hammen, C. (1999). Age and gender as determinants of stress exposure, generation, and reactions in youngsters: a transactional perspective. Child Development, 70, 660–677.PubMedCrossRef

Schoebi, D., Way, B. M., Karney, B. R., & Bradbury, T. N. (2011). Genetic moderation of sensitivity to positive and negative affect in marriage.

Shih, J., Eberhart, N., Hammen, C., & Brennan, P. (2006). Differential exposure and reactivity to interpersonal stress predict sex differences in adolescent depression. Journal of Clinical Child and Adolescent Psychology, 35, 103–115. doi:10.1207/s15374424jccp3501_9.PubMed

Sjöberg, R. L., Nilsson, K. W., Nordquist, N., Öhrvik, J., Leppert, J., Lindström, L., et al. (2006). Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. The International Journal of Neuropsychopharmacology, 9, 443–449. doi:10.1017/S1461145705005936.PubMedCrossRef

Spitzer, R. L., Williams, J. B. W., Gibbon, M., & First, M. (1995). Structured Clinical Interview for DSM-IV (SCID-IV). Washington, DC: American Psychiatric Association.

Starr, L. R., Hammen, C., Brennan, P. A., & Najman, J. (2012). Serotonin transporter gene as a predictor of stress generation in depression. Journal of Abnormal Psychology. doi:10.1037/a0027952.

Taylor, S. E., Way, B. M., Welch, W. T., Hilmert, C. J., Lehman, B. J., & Eisenberger, N. I. (2006). Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biological Psychiatry, 60, 671–676.PubMedCrossRef

Waters, H. S., Rodrigues, L. M., & Ridgeway, D. (1998). Cognitive underpinnings of narrative attachment assessment. Journal of Experimental Child Psychology, 71, 211–234. doi:10.1006/jecp. 1998.2473.PubMedCrossRef

Way, B. M., & Taylor, S. E. (2010). Social influences on health: is serotonin a critical mediator? Psychosomatic Medicine, 72, 107–112. doi:10.1097/PSY.0b013e3181ce6a7d.PubMedCrossRef

Wendland, J. R., Martin, B. J., Kruse, M. R., Lesch, K. P., & Murphy, D. L. (2006). Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Molecular Psychiatry, 11, 224–226.PubMedCrossRef

Zimmermann, P., Mohr, C., & Spangler, G. (2009). Genetic and attachment influences on adolescents’ regulation of autonomy and aggressiveness. Journal of Child Psychology and Psychiatry, 50, 1339–1347. doi:10.1111/j.1469-7610.2009.02158.x.PubMedCrossRef

Titel: Relational Security Moderates the Effect of Serotonin Transporter Gene Polymorphism (5-HTTLPR) on Stress Generation and Depression among Adolescents
Auteurs: Lisa R. Starr
Constance Hammen
Patricia A. Brennan
Jake M. Najman
Publicatiedatum: 01-04-2013
Uitgeverij: Springer US
Gepubliceerd in: Research on Child and Adolescent Psychopathology / Uitgave 3/2013
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI: https://doi.org/10.1007/s10802-012-9682-z

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