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Journal of Autism and Developmental Disorders

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01-03-2009 | Original Paper

Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism

Auteurs: Flora M. Vaccarino, Elena L. Grigorenko, Karen Müller Smith, Hanna E. Stevens

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2009

Abstract

Increased brain size is common in children with autism spectrum disorders. Here we propose that an increased number of cortical excitatory neurons may underlie the increased brain volume, minicolumn pathology and excessive network excitability, leading to sensory hyper-reactivity and seizures, which are often found in autism. We suggest that Fibroblast Growth Factors (FGF), a family of genes that regulate cortical size and connectivity, may be responsible for these developmental alterations. Studies in animal models suggest that mutations in FGF genes lead to altered cortical volume, excitatory cortical neuron number, minicolum pathology, hyperactivity and social deficits. Thus, many risk factors may converge upon FGF-regulated pathogenetic pathways, which alter excitatory/inhibitory balance and cortical modular architecture, and predispose to autism spectrum disorders.

vorige artikel Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

volgende artikel Intrinsic and Extrinsic Motivation for Stereotypic and Repetitive Behavior

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Titel: Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism
Auteurs: Flora M. Vaccarino
Elena L. Grigorenko
Karen Müller Smith
Hanna E. Stevens
Publicatiedatum: 01-03-2009
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 3/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-008-0653-8

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