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Gepubliceerd in: Journal of Autism and Developmental Disorders 3/2009

01-03-2009 | Original Paper

Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism

Auteurs: Flora M. Vaccarino, Elena L. Grigorenko, Karen Müller Smith, Hanna E. Stevens

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2009

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Abstract

Increased brain size is common in children with autism spectrum disorders. Here we propose that an increased number of cortical excitatory neurons may underlie the increased brain volume, minicolumn pathology and excessive network excitability, leading to sensory hyper-reactivity and seizures, which are often found in autism. We suggest that Fibroblast Growth Factors (FGF), a family of genes that regulate cortical size and connectivity, may be responsible for these developmental alterations. Studies in animal models suggest that mutations in FGF genes lead to altered cortical volume, excitatory cortical neuron number, minicolum pathology, hyperactivity and social deficits. Thus, many risk factors may converge upon FGF-regulated pathogenetic pathways, which alter excitatory/inhibitory balance and cortical modular architecture, and predispose to autism spectrum disorders.
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Metagegevens
Titel
Regulation of Cerebral Cortical Size and Neuron Number by Fibroblast Growth Factors: Implications for Autism
Auteurs
Flora M. Vaccarino
Elena L. Grigorenko
Karen Müller Smith
Hanna E. Stevens
Publicatiedatum
01-03-2009
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-008-0653-8

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