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Roof Plate in Cerebellar Neurogenesis

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Handbook of the Cerebellum and Cerebellar Disorders

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Abstract

The roof plate is a distinct group of cells located at the dorsal midline of the developing central nervous system extending along its entire anterior–posterior axis. In the developing hindbrain, the roof plate comprises a simple epithelial layer covering the dorsal opening of the 4th ventricle. As development proceeds, the 4th ventricle roof plate differentiates into choroid plexus epithelium, which produces cerebrospinal fluid and serves as a blood-cerebrospinal fluid barrier. A growing amount of evidence indicates that both the 4th ventricle roof plate and its later derivative, the hindbrain choroid plexus, produce various secreted molecules, which critically regulate development of the adjacent cerebellum. Bone morphogenetic proteins secreted from the roof plate are crucial to the induction of the cerebellar rhombic lip. Signals from the early roof plate and later secretion of Sonic hedgehog from the choroid plexus promote proliferation of progenitors in the cerebellar ventricular zone. This chapter discusses recent studies that established the roles of the 4th ventricle roof plate and the hindbrain choroid plexus in cerebellar neurogenesis and the molecular mechanisms of their action.

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Authors and Affiliations

  1. Center for Integrative Brain Research, Seattle Children’s Hospital Research Institute, 1900, 9th Avenue, Mailstop C9S-10, Seattle, WA, 98101, USA

    Dr. Victor V. Chizhikov

Authors
  1. Dr. Victor V. Chizhikov
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Correspondence to Victor V. Chizhikov .

Editor information

Editors and Affiliations

  1. Unité d'Etude du Mouvement (UEM), FNRS, Neurologie ULB Erasme, Bruxelles, Belgium

    Mario Manto

  2. Ataxia Unit, Cognitive and Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

  3. Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), University of Turin, Orbassano, Turin, Italy

    Ferdinando Rossi

  4. Molecular and Integrative Neuroscience Department (MIND), The Scripps Research Institute, California, CA, USA

    Donna L. Gruol

  5. Department of Integrative Physiolgy, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

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Chizhikov, V.V. (2013). Roof Plate in Cerebellar Neurogenesis. In: Manto, M., Schmahmann, J.D., Rossi, F., Gruol, D.L., Koibuchi, N. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1333-8_4

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