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Development of Glutamatergic and GABAergic Synapses

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Handbook of the Cerebellum and Cerebellar Disorders

Abstract

More than a century ago, Ramón y Cajal based on the cerebellum his initial description of neurons labeled with the silver impregnation method, obtaining evidence in favor of the neuron doctrine. It is perhaps less known that Cajal also made an accurate description of cerebellar development, laying the foundation for successive studies of cell migration, neuronal differentiation, and synaptogenesis. Building on this work, subsequent analyses of cerebellar development have greatly increased the understanding of cellular and molecular events that regulate the assembly of synaptic circuits in the central nervous system. What makes the cerebellum a particularly useful model system is its delayed course of development, largely extending into postnatal life. This chapter describes the current state of knowledge relating to cerebellar synapse development, and reviews recent studies on the molecular and activity-dependent mechanisms that control the spatial specificity of synaptogenesis.

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Authors and Affiliations

  1. Department of Anatomy, Pharmacology, and Forensic Medicine, National Institute of Neuroscience–Italy, C.so Massimo d’Azeglio, 52, I-10126, Turin, Italy

    Marco Sassoè-Pognetto & Annarita Patrizi

  2. F.M. Kirby Neurobiology Center, Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, CLS 13034, Boston, MA, 02115, USA

    Annarita Patrizi

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  1. Marco Sassoè-Pognetto
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  2. Annarita Patrizi
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Correspondence to Marco Sassoè-Pognetto .

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Editors and Affiliations

  1. Unité d'Etude du Mouvement (UEM), FNRS, Neurologie ULB Erasme, Bruxelles, Belgium

    Mario Manto

  2. Ataxia Unit, Cognitive and Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

  3. Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), University of Turin, Orbassano, Turin, Italy

    Ferdinando Rossi

  4. Molecular and Integrative Neuroscience Department (MIND), The Scripps Research Institute, California, CA, USA

    Donna L. Gruol

  5. Department of Integrative Physiolgy, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

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Sassoè-Pognetto, M., Patrizi, A. (2013). Development of Glutamatergic and GABAergic Synapses. In: Manto, M., Schmahmann, J.D., Rossi, F., Gruol, D.L., Koibuchi, N. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1333-8_12

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