Definition
A large family of acidic adaptor proteins of ∼30 kDa that mainly (but not solely) interact with phosphoserine or -threonine sites on target proteins to facilitate their activity. 14-3-3 proteins have 9–10 alpha helices, generally form homo- or heterodimers, and contain a number of common modification sites (e.g. phosphorylation, divalent cation binding, and so forth) to regulate their activities, interactions, and localizations.
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© 2008 Springer-Verlag GmbH Berlin Heidelberg
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(2008). 14-3-3. In: Binder, M.D., Hirokawa, N., Windhorst, U. (eds) Encyclopedia of Neuroscience. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29678-2_3
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DOI: https://doi.org/10.1007/978-3-540-29678-2_3
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-23735-8
Online ISBN: 978-3-540-29678-2
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