Synonyms
Definition
It is the non-methylable analogue of cytosine base. It is not a naturally occurring base but can be incorporated into DNA during replication and into RNA during transcription by growing the cells in media containing 5-azacytidine as a drug or incorporated during in vitro reaction. It is also known to inhibit DNA methyltransferases (DNMTs) thereby, causing lack of methylation in DNA sequence, affecting the interaction between regulatory protein and the nucleic acid target. The inhibition of methylation occurs through the formation of stable complexes between the molecule and DNMTs, thereby saturating cell methylation machinery. It is known to target the CpG islands in the human genome, especially in the promoter regions of genes susceptible to aberrant hypermethylation. Such analogues can be used for modulation of DNA methylation (Kaminskas et al. 2005).
Cross-References
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kaminskas E, Farrell AT, Wang YC, Sridhara R, Pazdur R (2005) FDA drug approval summary: azacitidine (5-azacytidine, Vidaza) for injectable suspension. Oncologist 10(3):176–182
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media, LLC
About this entry
Cite this entry
Brahmachari, V., Jain, S. (2013). 5-azaCytosine. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_862
Download citation
DOI: https://doi.org/10.1007/978-1-4419-9863-7_862
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-9862-0
Online ISBN: 978-1-4419-9863-7
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences