Definition
A DNA-binding protein that stimulates transcription of one or more genes. Most activators recruit RNA polymerase to promoter region by interacting directly with a subunit of DNA polymerase and serving as a liaison between RNA polymerase and DNA, or change DNA conformation to promote the transition to the open complex required for initiation of transcription.
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Ruan, J. (2013). Activator. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_305
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_305
Publisher Name: Springer, New York, NY
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Online ISBN: 978-1-4419-9863-7
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