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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-04-2014 | Original Paper

Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders

Auteurs: Leonardo Emberti Gialloreti, Matteo Pardini, Francesca Benassi, Sara Marciano, Mario Amore, Maria Giulia Mutolo, Maria Cristina Porfirio, Paolo Curatolo

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2014

Abstract

Recent years have seen an increase in the use of retinal nerve fiber layer (RNFL) evaluation as an easy-to-use, reproducible, proxy-measure of brain structural abnormalities. Here, we evaluated RNFL thickness in a group of subjects with high functioning autism (HFA) or with Asperger Syndrome (AS) to its potential as a tool to study autism pathophysiology. All subjects underwent high-resolution spectral domain optical coherence tomography to evaluate RNFL thickness. HFA subjects presented with reduced global RNFL thickness compared both to AS subjects and controls. AS subjects showed a reduced nasal quadrant RNFL thickness compared to controls. Verbal-IQ/performance-IQ discrepancy correlated with RNFL thickness. Our data suggest that RNFL evaluation could help in the development of biological markers of autism pathophysiology.

vorige artikel Using Self- and Parent-Reports to Test the Association Between Peer Victimization and Internalizing Symptoms in Verbally Fluent Adolescents with ASD

volgende artikel Use of a Peer Support Intervention for Promoting Academic Engagement of Students with Autism in General Education Settings

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Titel: Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders
Auteurs: Leonardo Emberti Gialloreti
Matteo Pardini
Francesca Benassi
Sara Marciano
Mario Amore
Maria Giulia Mutolo
Maria Cristina Porfirio
Paolo Curatolo
Publicatiedatum: 01-04-2014
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 4/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-013-1939-z

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