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Gepubliceerd in: Journal of Autism and Developmental Disorders 4/2014

01-04-2014 | Original Paper

Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders

Auteurs: Leonardo Emberti Gialloreti, Matteo Pardini, Francesca Benassi, Sara Marciano, Mario Amore, Maria Giulia Mutolo, Maria Cristina Porfirio, Paolo Curatolo

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2014

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Abstract

Recent years have seen an increase in the use of retinal nerve fiber layer (RNFL) evaluation as an easy-to-use, reproducible, proxy-measure of brain structural abnormalities. Here, we evaluated RNFL thickness in a group of subjects with high functioning autism (HFA) or with Asperger Syndrome (AS) to its potential as a tool to study autism pathophysiology. All subjects underwent high-resolution spectral domain optical coherence tomography to evaluate RNFL thickness. HFA subjects presented with reduced global RNFL thickness compared both to AS subjects and controls. AS subjects showed a reduced nasal quadrant RNFL thickness compared to controls. Verbal-IQ/performance-IQ discrepancy correlated with RNFL thickness. Our data suggest that RNFL evaluation could help in the development of biological markers of autism pathophysiology.
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Metagegevens
Titel
Reduction in Retinal Nerve Fiber Layer Thickness in Young Adults with Autism Spectrum Disorders
Auteurs
Leonardo Emberti Gialloreti
Matteo Pardini
Francesca Benassi
Sara Marciano
Mario Amore
Maria Giulia Mutolo
Maria Cristina Porfirio
Paolo Curatolo
Publicatiedatum
01-04-2014
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 4/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-1939-z

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