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Gepubliceerd in: Child Psychiatry & Human Development 2/2013

01-04-2013 | Original Article

Reduced Prefrontal Hemodynamic Response in Pediatric Obsessive–Compulsive Disorder as Measured by Near-Infrared Spectroscopy

Auteurs: Toyosaku Ota, Junzo Iida, Masayuki Sawada, Yuko Suehiro, Kazuhiko Yamamuro, Hiroki Matsuura, Shohei Tanaka, Naoko Kishimoto, Hideki Negoro, Toshifumi Kishimoto

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 2/2013

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Abstract

Recent developments in near-infrared spectroscopy (NIRS) have enabled non-invasive clarification of brain functions in psychiatric disorders. Functional neuroimaging studies of patients with obsessive–compulsive disorder (OCD) have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of the disorder. Twelve treatment-naïve children with OCD and 12 age- and sex-matched healthy control subjects participated in the present study after giving consent. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 s during the Stroop color-word task, using 24-channel NIRS machines. During the Stroop color-word task, the oxy-Hb changes in the OCD group were significantly smaller than those in the control group in the prefrontal cortex, especially in the frontopolar cortex. The present study suggests that children with OCD have reduced prefrontal hemodynamic response as measured by NIRS.
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Metagegevens
Titel
Reduced Prefrontal Hemodynamic Response in Pediatric Obsessive–Compulsive Disorder as Measured by Near-Infrared Spectroscopy
Auteurs
Toyosaku Ota
Junzo Iida
Masayuki Sawada
Yuko Suehiro
Kazuhiko Yamamuro
Hiroki Matsuura
Shohei Tanaka
Naoko Kishimoto
Hideki Negoro
Toshifumi Kishimoto
Publicatiedatum
01-04-2013
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 2/2013
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-012-0323-0

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