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01-02-2015 | Original Paper

Reduced Interhemispheric Connectivity in Childhood Autism Detected by Electroencephalographic Photic Driving Coherence

Auteurs: Vladimir V. Lazarev, Adailton Pontes, Andrey A. Mitrofanov, Leonardo C. deAzevedo

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2015

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Abstract

The EEG coherence among 14 scalp points during intermittent photic stimulation at 11 fixed frequencies of 3–24 Hz was studied in 14 boys with autism, aged 6–14 years, with relatively intact verbal and intellectual functions, and 19 normally developing boys. The number of interhemispheric coherent connections pertaining to the 20 highest connections of each individual was significantly lower in autistic patients than in the control group at all the EEG beta frequencies corresponding to those of stimulation. The coefficient of coherence values between homologous occipital, parietal and central areas at the same frequencies were also lower in the autistic group in both mono- and bipolar montages due to a deficit in reactive photic driving increase. No differences between the groups were observed in the spontaneous EEG.
Literatuur
go back to reference American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, DSM-IV-TR (4th ed.). Washington, DC: American Psychiatric Press. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, DSM-IV-TR (4th ed.). Washington, DC: American Psychiatric Press.
go back to reference Anderson, J. S., Druzgal, T. J., Froehlich, A., DuBray, M. B., Lange, N., Alexander, A. L., et al. (2011). Decreased interhemispheric functional connectivity in autism. Cerebral Cortex, 21, 1134–1146.PubMedCentralPubMedCrossRef Anderson, J. S., Druzgal, T. J., Froehlich, A., DuBray, M. B., Lange, N., Alexander, A. L., et al. (2011). Decreased interhemispheric functional connectivity in autism. Cerebral Cortex, 21, 1134–1146.PubMedCentralPubMedCrossRef
go back to reference Anokhin, P. K. (1974). Biology and neurophysiology of the conditioned reflex and its role in adaptive behavior. Oxford: Pergamon. Anokhin, P. K. (1974). Biology and neurophysiology of the conditioned reflex and its role in adaptive behavior. Oxford: Pergamon.
go back to reference Belmonte, M. K., Cook, E. H., Jr, Anderson, G. M., Rubenstein, J. L., Greenough, W. T., Beckel-Mitchener, A., et al. (2004). Autism as a disorder of neural information processing: Directions for research and targets for therapy. Molecular Psychiatry, 9, 646–663.PubMed Belmonte, M. K., Cook, E. H., Jr, Anderson, G. M., Rubenstein, J. L., Greenough, W. T., Beckel-Mitchener, A., et al. (2004). Autism as a disorder of neural information processing: Directions for research and targets for therapy. Molecular Psychiatry, 9, 646–663.PubMed
go back to reference Carter, G. C. (1987). Coherence and time delay estimation. Proceedings of the IEEE, 75, 236–255.CrossRef Carter, G. C. (1987). Coherence and time delay estimation. Proceedings of the IEEE, 75, 236–255.CrossRef
go back to reference Coben, R., Clarke, A. R., Hudspeth, W., & Barry, R. J. (2008). EEG power and coherence in autistic spectrum disorder. Clinical Neurophysiology, 119, 1002–1009.PubMedCrossRef Coben, R., Clarke, A. R., Hudspeth, W., & Barry, R. J. (2008). EEG power and coherence in autistic spectrum disorder. Clinical Neurophysiology, 119, 1002–1009.PubMedCrossRef
go back to reference Fedotchev, A. I., Bondar, A. T., & Konovalov, V. F. (1990). Stability of resonance EEG reactions to flickering light in humans. International Journal of Psychophysiology, 9, 189–193.PubMedCrossRef Fedotchev, A. I., Bondar, A. T., & Konovalov, V. F. (1990). Stability of resonance EEG reactions to flickering light in humans. International Journal of Psychophysiology, 9, 189–193.PubMedCrossRef
go back to reference Filipek, P. A., Accardo, P. J., Ashwal, S., Baranek, G. T., Cook, E. H., Jr, Dawson, G., et al. (2000). Practice parameter: Screening and diagnosis of autism: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology, 55, 468–479.PubMedCrossRef Filipek, P. A., Accardo, P. J., Ashwal, S., Baranek, G. T., Cook, E. H., Jr, Dawson, G., et al. (2000). Practice parameter: Screening and diagnosis of autism: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology, 55, 468–479.PubMedCrossRef
go back to reference Filipek, P. A., Accardo, P. J., Baranek, G. T., Cook, E. H., Jr, Dawson, G., Gordon, B., et al. (1999). The screening and diagnosis of autistic spectrum disorders. Journal of Autism and Developmental Disorders, 29, 439–484.PubMedCrossRef Filipek, P. A., Accardo, P. J., Baranek, G. T., Cook, E. H., Jr, Dawson, G., Gordon, B., et al. (1999). The screening and diagnosis of autistic spectrum disorders. Journal of Autism and Developmental Disorders, 29, 439–484.PubMedCrossRef
go back to reference French, C. C., & Beaumont, J. C. (1984). A critical review of EEG coherence studies of hemisphere function. International Journal of Psychophysiology, 1, 241–254.PubMedCrossRef French, C. C., & Beaumont, J. C. (1984). A critical review of EEG coherence studies of hemisphere function. International Journal of Psychophysiology, 1, 241–254.PubMedCrossRef
go back to reference Grice, S. J., Spratling, M. W., Karmiloff-Smith, A., Halit, H., Csibra, G., de Haan, M., et al. (2001). Disordered visual processing and oscillatory brain activity in autism and Williams syndrome. Neuroreport, 12, 2697–2700.PubMedCrossRef Grice, S. J., Spratling, M. W., Karmiloff-Smith, A., Halit, H., Csibra, G., de Haan, M., et al. (2001). Disordered visual processing and oscillatory brain activity in autism and Williams syndrome. Neuroreport, 12, 2697–2700.PubMedCrossRef
go back to reference Herrmann, C. S., & Demiralp, T. (2005). Human EEG gamma oscillations in neuropsychiatric disorders. Clinical Neurophysiology, 116, 2719–2733.PubMedCrossRef Herrmann, C. S., & Demiralp, T. (2005). Human EEG gamma oscillations in neuropsychiatric disorders. Clinical Neurophysiology, 116, 2719–2733.PubMedCrossRef
go back to reference Hirota, T., Yagyu, T., Pascual-Marqui, R. D., Saito, N., & Kinoshita, T. (2001). Spatial structure of brain electric fields during intermittent photic stimulation. Neuropsychobiology, 44, 108–112.PubMedCrossRef Hirota, T., Yagyu, T., Pascual-Marqui, R. D., Saito, N., & Kinoshita, T. (2001). Spatial structure of brain electric fields during intermittent photic stimulation. Neuropsychobiology, 44, 108–112.PubMedCrossRef
go back to reference Honaga, E., Ishii, R., Kurimoto, R., Canuet, L., Ikezawa, K., Takahashi, H., et al. (2010). Post-movement beta rebound abnormality as indicator of mirror neuron system dysfunction in autistic spectrum disorder: An MEG study. Neuroscience Letters, 478, 141–145.PubMedCrossRef Honaga, E., Ishii, R., Kurimoto, R., Canuet, L., Ikezawa, K., Takahashi, H., et al. (2010). Post-movement beta rebound abnormality as indicator of mirror neuron system dysfunction in autistic spectrum disorder: An MEG study. Neuroscience Letters, 478, 141–145.PubMedCrossRef
go back to reference Isler, J. R., Martien, K. M., Grieve, P. G., Stark, R. I., & Herbert, M. R. (2010). Reduced functional connectivity in visual evoked potentials in children with autism spectrum disorder. Clinical Neurophysiology, 121, 2035–2043.PubMedCrossRef Isler, J. R., Martien, K. M., Grieve, P. G., Stark, R. I., & Herbert, M. R. (2010). Reduced functional connectivity in visual evoked potentials in children with autism spectrum disorder. Clinical Neurophysiology, 121, 2035–2043.PubMedCrossRef
go back to reference Jenkins, G. M., & Watts, D. G. (1968). Spectral analysis and its application. San Francisco: Holden-Day. Jenkins, G. M., & Watts, D. G. (1968). Spectral analysis and its application. San Francisco: Holden-Day.
go back to reference John, E. R., & Schwartz, E. L. (1978). The neurophysiology of information processing and cognition. Annual Review of Psychology, 29, 1–29.PubMedCrossRef John, E. R., & Schwartz, E. L. (1978). The neurophysiology of information processing and cognition. Annual Review of Psychology, 29, 1–29.PubMedCrossRef
go back to reference Johnson, C. P., Myers, S. M., & American Academy of Pediatrics Council on Children With Disabilities. (2007). Identification and evaluation of children with autism spectrum disorders. Review. Pediatrics, 120, 1183–1215.PubMedCrossRef Johnson, C. P., Myers, S. M., & American Academy of Pediatrics Council on Children With Disabilities. (2007). Identification and evaluation of children with autism spectrum disorders. Review. Pediatrics, 120, 1183–1215.PubMedCrossRef
go back to reference Just, M. A., Cherkassky, V. L., Keller, T. A., Kana, R. K., & Minshew, N. J. (2007). Functional and anatomical cortical underconnectivity in autism: Evidence from an FMRI study of an executive function task and corpus callosum morphometry. Cerebral Cortex, 17, 951–961.PubMedCrossRef Just, M. A., Cherkassky, V. L., Keller, T. A., Kana, R. K., & Minshew, N. J. (2007). Functional and anatomical cortical underconnectivity in autism: Evidence from an FMRI study of an executive function task and corpus callosum morphometry. Cerebral Cortex, 17, 951–961.PubMedCrossRef
go back to reference Kaiser, J., & Gruzelier, J. H. (1996). Timing of puberty and EEG coherence during photic stimulation. International Journal of Psychophysiology, 21, 135–149.PubMedCrossRef Kaiser, J., & Gruzelier, J. H. (1996). Timing of puberty and EEG coherence during photic stimulation. International Journal of Psychophysiology, 21, 135–149.PubMedCrossRef
go back to reference Knyazeva, M. G., & Innocenti, G. M. (2001). EEG coherence studies in the normal brain and after early-onset cortical pathologies. Review. Brain Research Reviews, 36, 119–128.PubMedCrossRef Knyazeva, M. G., & Innocenti, G. M. (2001). EEG coherence studies in the normal brain and after early-onset cortical pathologies. Review. Brain Research Reviews, 36, 119–128.PubMedCrossRef
go back to reference Lazarev, V. V. (2006). The relationship of theory and methodology in EEG studies of mental activity. International Journal of Psychophysiology, 62, 384–393.PubMedCrossRef Lazarev, V. V. (2006). The relationship of theory and methodology in EEG studies of mental activity. International Journal of Psychophysiology, 62, 384–393.PubMedCrossRef
go back to reference Lazarev, V. V., Infantosi, A. F. C., Valencio-de-Campos, D., & deAzevedo, L. C. (2004). Topographic aspects of photic driving in the electroencephalogram of children and adolescents. Brazilian Journal of Medical and Biological Research, 37, 879–891.PubMedCrossRef Lazarev, V. V., Infantosi, A. F. C., Valencio-de-Campos, D., & deAzevedo, L. C. (2004). Topographic aspects of photic driving in the electroencephalogram of children and adolescents. Brazilian Journal of Medical and Biological Research, 37, 879–891.PubMedCrossRef
go back to reference Lazarev, V. V., Pontes, A., & deAzevedo, L. C. (2009). EEG photic driving: Right-hemisphere reactivity deficit in childhood autism. A pilot study. International Journal of Psychophysiology, 71, 177–183.PubMedCrossRef Lazarev, V. V., Pontes, A., & deAzevedo, L. C. (2009). EEG photic driving: Right-hemisphere reactivity deficit in childhood autism. A pilot study. International Journal of Psychophysiology, 71, 177–183.PubMedCrossRef
go back to reference Lazarev, V. V., Pontes, A., Mitrofanov, A. A., & deAzevedo, L. C. (2010). Interhemispheric asymmetry in EEG photic driving coherence in childhood autism. Clinical Neurophysiology, 121, 145–152.PubMedCrossRef Lazarev, V. V., Pontes, A., Mitrofanov, A. A., & deAzevedo, L. C. (2010). Interhemispheric asymmetry in EEG photic driving coherence in childhood autism. Clinical Neurophysiology, 121, 145–152.PubMedCrossRef
go back to reference Lazarev, V. V., Simpson, D. M., Schubsky, B. M., & deAzevedo, L. C. (2001). Photic driving in the electroencephalogram of children and adolescents: harmonic structure and relation to the resting state. Brazilian Journal of Medical and Biological Research, 34, 1573–1584.PubMedCrossRef Lazarev, V. V., Simpson, D. M., Schubsky, B. M., & deAzevedo, L. C. (2001). Photic driving in the electroencephalogram of children and adolescents: harmonic structure and relation to the resting state. Brazilian Journal of Medical and Biological Research, 34, 1573–1584.PubMedCrossRef
go back to reference Léveillé, C., Barbeau, E. B., Bolduc, C., Limoges, E., Berthiaume, C., Chevrier, E., et al. (2010). Enhanced connectivity between visual cortex and other regions of the brain in autism: A REM sleep EEG coherence study. Autism Research, 3, 280–285.PubMedCrossRef Léveillé, C., Barbeau, E. B., Bolduc, C., Limoges, E., Berthiaume, C., Chevrier, E., et al. (2010). Enhanced connectivity between visual cortex and other regions of the brain in autism: A REM sleep EEG coherence study. Autism Research, 3, 280–285.PubMedCrossRef
go back to reference Livanov, M. N. (1977). Spatial organization of cerebral processes. New York: Wiley. Livanov, M. N. (1977). Spatial organization of cerebral processes. New York: Wiley.
go back to reference Luria, A. R. (1966). Higher cortical functions in Man. New York: Basic Books. Luria, A. R. (1966). Higher cortical functions in Man. New York: Basic Books.
go back to reference Miranda de Sa, A. M. F. L., Infantosi, A. F. C., & Simpson, D. M. (2001). A statistical technique for measuring synchronism between cortical regions in the EEG during rhythmic stimulation. IEEE Transactions on Biomedical Engineering, 48, 1211–1215.PubMedCrossRef Miranda de Sa, A. M. F. L., Infantosi, A. F. C., & Simpson, D. M. (2001). A statistical technique for measuring synchronism between cortical regions in the EEG during rhythmic stimulation. IEEE Transactions on Biomedical Engineering, 48, 1211–1215.PubMedCrossRef
go back to reference Nunez, P. L., Srinivasan, R., Westdorp, A. F., Wijesinghe, R. S., Tucker, D. M., Silberstein, R. B., et al. (1997). EEG coherency. I: Statistics, reference electrode, volume conduction, Laplacians, cortical imaging, and interpretation at multiple scales. Electroencephalography and Clinical Neurophysiology, 103, 499–515.PubMedCrossRef Nunez, P. L., Srinivasan, R., Westdorp, A. F., Wijesinghe, R. S., Tucker, D. M., Silberstein, R. B., et al. (1997). EEG coherency. I: Statistics, reference electrode, volume conduction, Laplacians, cortical imaging, and interpretation at multiple scales. Electroencephalography and Clinical Neurophysiology, 103, 499–515.PubMedCrossRef
go back to reference Oberman, L. M., Hubbard, E. M., McCleery, J. P., Altschuler, E. L., Ramachandran, V. S., & Pineda, J. A. (2005). EEG evidence for mirror neuron dysfunction in autism spectrum disorders. Cognitive Brain Research, 24, 190–198.PubMedCrossRef Oberman, L. M., Hubbard, E. M., McCleery, J. P., Altschuler, E. L., Ramachandran, V. S., & Pineda, J. A. (2005). EEG evidence for mirror neuron dysfunction in autism spectrum disorders. Cognitive Brain Research, 24, 190–198.PubMedCrossRef
go back to reference Petsche, H., Etlinger, S. C., & Filz, O. (1993). Brain electrical mechanisms of bilingual speech management: an initial investigation. Electroencephalography and Clinical Neurophysiology, 86, 385–394.PubMedCrossRef Petsche, H., Etlinger, S. C., & Filz, O. (1993). Brain electrical mechanisms of bilingual speech management: an initial investigation. Electroencephalography and Clinical Neurophysiology, 86, 385–394.PubMedCrossRef
go back to reference Rizzolatti, G., & Fabbri-Destro, M. (2010). Mirror neurons: From discovery to autism. Experimental Brain Research, 200, 223–237.PubMedCrossRef Rizzolatti, G., & Fabbri-Destro, M. (2010). Mirror neurons: From discovery to autism. Experimental Brain Research, 200, 223–237.PubMedCrossRef
go back to reference Singer, W. (1999). Neuronal synchrony: A versatile code for the definition of relations? Neuron, 24, 49–65.PubMedCrossRef Singer, W. (1999). Neuronal synchrony: A versatile code for the definition of relations? Neuron, 24, 49–65.PubMedCrossRef
go back to reference Stroganova, T. A., Orekhova, E. V., Prokofyev, A. O., Tsetlin, M. M., Gratchev, V. V., Morozov, A. A., et al. (2012). High-frequency oscillatory response to illusory contour in typically developing boys and boys with autism spectrum disorders. Córtex, 48, 701–717.PubMed Stroganova, T. A., Orekhova, E. V., Prokofyev, A. O., Tsetlin, M. M., Gratchev, V. V., Morozov, A. A., et al. (2012). High-frequency oscillatory response to illusory contour in typically developing boys and boys with autism spectrum disorders. Córtex, 48, 701–717.PubMed
go back to reference Takahashi, T. (1987). Activation methods. In E. Niedermeyer & F. H. Lopes da Silva (Eds.), Electroencephalography: basic principles, clinical applications and related fields (2nd ed., pp. 209–227). Baltimore: Urban-Schwarzenberg. Takahashi, T. (1987). Activation methods. In E. Niedermeyer & F. H. Lopes da Silva (Eds.), Electroencephalography: basic principles, clinical applications and related fields (2nd ed., pp. 209–227). Baltimore: Urban-Schwarzenberg.
go back to reference Uhlhaas, P. J., & Singer, W. (2007). Editorial. What do disturbances in neural synchrony tell us about autism? Biological Psychiatry, 62, 190–191.PubMedCrossRef Uhlhaas, P. J., & Singer, W. (2007). Editorial. What do disturbances in neural synchrony tell us about autism? Biological Psychiatry, 62, 190–191.PubMedCrossRef
go back to reference Vissers, M. E., Cohen, M. X., & Geurts, H. M. (2012). Brain connectivity and high functioning autism: A promising path of research that needs refined models, methodological convergence, and stronger behavioral links. Neuroscience and Biobehavioral Reviews, 36, 604–625.PubMedCrossRef Vissers, M. E., Cohen, M. X., & Geurts, H. M. (2012). Brain connectivity and high functioning autism: A promising path of research that needs refined models, methodological convergence, and stronger behavioral links. Neuroscience and Biobehavioral Reviews, 36, 604–625.PubMedCrossRef
go back to reference Wada, Y., Nanbu, Y., Jiang, Z. Y., Koshino, Y., & Hashimoto, T. (1998). Interhemispheric EEG coherence in never-medicated patients with paranoid schizophrenia: Analysis at rest and during photic stimulation. Clinical Electroencephalography, 29, 170–176.PubMedCrossRef Wada, Y., Nanbu, Y., Jiang, Z. Y., Koshino, Y., & Hashimoto, T. (1998). Interhemispheric EEG coherence in never-medicated patients with paranoid schizophrenia: Analysis at rest and during photic stimulation. Clinical Electroencephalography, 29, 170–176.PubMedCrossRef
go back to reference Wada, Y., Nanbu, Y., Kadoshima, R., Jiang, Z. Y., Koshino, Y., & Hashimoto, T. (1996). Interhemispheric EEG coherence during photic stimulation: Sex differences in normal young adults. International Journal of Psychophysiology, 22, 45–51.PubMedCrossRef Wada, Y., Nanbu, Y., Kadoshima, R., Jiang, Z. Y., Koshino, Y., & Hashimoto, T. (1996). Interhemispheric EEG coherence during photic stimulation: Sex differences in normal young adults. International Journal of Psychophysiology, 22, 45–51.PubMedCrossRef
go back to reference Wang, S. Y., Liu, X., Yianni, J., Miall, R. C., Aziz, T. Z., & Stein, J. F. (2004). Optimizing coherence estimation to assess the functional correlation of tremor-related activity between the subthalamic nucleus and the forearm muscles. Journal of Neuroscience Methods, 136, 197–205.PubMedCrossRef Wang, S. Y., Liu, X., Yianni, J., Miall, R. C., Aziz, T. Z., & Stein, J. F. (2004). Optimizing coherence estimation to assess the functional correlation of tremor-related activity between the subthalamic nucleus and the forearm muscles. Journal of Neuroscience Methods, 136, 197–205.PubMedCrossRef
go back to reference Wass, S. (2011). Distortions and disconnections: Disrupted brain connectivity in autism. Brain and Cognition, 75, 18–28.PubMedCrossRef Wass, S. (2011). Distortions and disconnections: Disrupted brain connectivity in autism. Brain and Cognition, 75, 18–28.PubMedCrossRef
go back to reference Wechsler, D. (1991). Wechsler intelligence scale for children (WISC-III). manual. San Antonio, TX: Psychological Corporation. Wechsler, D. (1991). Wechsler intelligence scale for children (WISC-III). manual. San Antonio, TX: Psychological Corporation.
go back to reference Zaveri, H. P., Williams, W. J., Sackellares, J. C., Beydoun, A., Duckrow, R. B., & Spencer, S. S. (1999). Measuring the coherence of intracranial electroencephalograms. Clinical Neurophysiology, 110, 1717–1725.PubMedCrossRef Zaveri, H. P., Williams, W. J., Sackellares, J. C., Beydoun, A., Duckrow, R. B., & Spencer, S. S. (1999). Measuring the coherence of intracranial electroencephalograms. Clinical Neurophysiology, 110, 1717–1725.PubMedCrossRef
Metagegevens
Titel
Reduced Interhemispheric Connectivity in Childhood Autism Detected by Electroencephalographic Photic Driving Coherence
Auteurs
Vladimir V. Lazarev
Adailton Pontes
Andrey A. Mitrofanov
Leonardo C. deAzevedo
Publicatiedatum
01-02-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-1959-8