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Gepubliceerd in: Journal of Autism and Developmental Disorders 5/2008

01-05-2008 | Original Paper

Reduced Bone Cortical Thickness in Boys with Autism or Autism Spectrum Disorder

Auteurs: Mary L. Hediger, Lucinda J. England, Cynthia A. Molloy, Kai F. Yu, Patricia Manning-Courtney, James L. Mills

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2008

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Abstract

Bone development, casein-free diet use, supplements, and medications were assessed for 75 boys with autism or autism spectrum disorder, ages 4–8 years. Second metacarpal bone cortical thickness (BCT), measured on hand-wrist radiographs, and % deviations in BCT from reference medians were derived. BCT increased with age, but % deviations evidenced a progressive fall-off (= .02): +3.1 ± 4.7%, −6.5 ± 4.0%, −16.6 ± 3.4%, −19.4 ± 3.7%, −24.1 ± 4.4%, at ages 4–8, respectively, adjusting for height. The 12% of the boys on casein-free diets had an overall % deviation of −18.9 ± 3.7%, nearly twice that of boys on minimally restricted or unrestricted diets (−10.5 ± 1.3%, < .04), although even for boys on minimally restricted or unrestricted diets the % deviation was highly significant (< .001). Our data suggest that the bone development of autistic boys should be monitored as part of routine care, especially if they are on casein-free diets.

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Metagegevens
Titel
Reduced Bone Cortical Thickness in Boys with Autism or Autism Spectrum Disorder
Auteurs
Mary L. Hediger
Lucinda J. England
Cynthia A. Molloy
Kai F. Yu
Patricia Manning-Courtney
James L. Mills
Publicatiedatum
01-05-2008
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2008
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-007-0453-6