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Bone development, casein-free diet use, supplements, and medications were assessed for 75 boys with autism or autism spectrum disorder, ages 4–8 years. Second metacarpal bone cortical thickness (BCT), measured on hand-wrist radiographs, and % deviations in BCT from reference medians were derived. BCT increased with age, but % deviations evidenced a progressive fall-off (p = .02): +3.1 ± 4.7%, −6.5 ± 4.0%, −16.6 ± 3.4%, −19.4 ± 3.7%, −24.1 ± 4.4%, at ages 4–8, respectively, adjusting for height. The 12% of the boys on casein-free diets had an overall % deviation of −18.9 ± 3.7%, nearly twice that of boys on minimally restricted or unrestricted diets (−10.5 ± 1.3%, p < .04), although even for boys on minimally restricted or unrestricted diets the % deviation was highly significant (p < .001). Our data suggest that the bone development of autistic boys should be monitored as part of routine care, especially if they are on casein-free diets.
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Aman, M. G., Lam, K. S. L., & Van Bourgondien, M. E. (2005). Medication patterns in patients with autism: Temporal, regional, and demographic influences. Journal of Child and Adolescnt Psychopharmacology, 15, 116–126. CrossRef
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders, 4th ed. Washington, DC: American Psychiatric Association.
Centers for Disease Control and Prevention (CDC). (2007). Prevalence of autism spectrum disorders—Autism and Developmental Disabilities Monitoring Network, six sites, United States, 2000. In: Surveillance Summaries, February 9, 2007. Morbidity and Mortality Weekly Report, 56(No. SS-1), 1–11.
Davies, J. H., Evans, B. A. J., & Gregory, J. W. (2005). Bone mass acquisition in healthy children. Archives of Diseases in Childhood, 90, 373–378. CrossRef
Dunn, H. G., & MacLeod, P. M. (2001). Rett syndrome: review of biological abnormalities. Canadian Journal of Neurological Sciences, 28, 16–29. PubMed
Garn, S. M., Poznanski, A. K., & Nagy, J. M. (1971). Bone measurement in the differential diagnosis of osteopenia and osteoporosis. Radiology, 100, 500–518.
Garn, S. M., Rohmann, C. G., & Silverman, F. N. (1967). Radiographic standards for postnatal ossification and tooth calcification. Medical Radiography and Photography, 43, 45–66. PubMed
Gerrior, S. (2001). Nutrient content of the US food supply. Home Economics Research Report no. 53. Washington, DC: United States Department of Agriculture, Center of Nutrition Policy and Promotion.
Gordon, C. C., Chumlea, W. C., & Roche, A. F. (1988). Stature, recumbent length, and weight. In: T. G. Lohman, A. F. Roche, & R. Martorell (Eds.), Anthropometric standardization reference manual (pp. 3–8). Champaign: Human Kinetics Books.
Helelä, T. (1969). Cortical thickness of metacarpal bones as an estimate of mineral content. Annals of Clinical Research, 1, 144–145. PubMed
Knivsberg, A. M., Reichelt, K. L., & Nødland, M. (2001). Reports on dietary intervention in autistic disorders. Nutritional Neuroscience, 4, 25–37.
Kuczmarski, R. J., Ogden, C. L., Grummer-Strawn, L. M., Flegal, K. M., Guo, S. S., Wei, R., et al. (2000). CDC growth charts: United States. Advance data from vital and health statistics; no. 314. Hyattsville, MD: National Center for Health Statistics. URL: http://www.cdc.gov/growthcharts/
Kumandas, S., Koklu, E., Gumus, H., Koklu, S., Kurtoglu, S., Karakukcu, M., & Keskin, M. (2006). Effect of carbamezapine and valproic acid on bone mineral density, IGF-I and IGFBP-3. Journal of Pediatric Endocrinology and Metabolism, 19, 529–534. PubMed
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223. PubMedCrossRef
Millward, C., Ferriter, M., Calver, S., & Connell-Jones, G. (2004). Gluten- and casein free diets for autistic spectrum disorder (review). The Cochrane Database of Systematic Reviews, Issue 2, Art. No. CD003498.pub2. DOI: 10.1002/14651858.CD003498.pub2.
Newschaffer, C. J., Falb, M. D., & Gurney, J. G. (2005). National autism prevalence trends from United States special education data. Pediatrics, 115, e277–e282. URL: http://www.pediatrics.org/cgi/doi/10.1542/peds.2004–1958
Niehus, R., & Lord, C. (2006). Early medical history of children with autism spectrum disorders. Journal of Developmental and Behavioral Pediatrics, 27, 120–127. CrossRef
Pack, A. M., Gidal, B., & Vazquez, B. (2004). Bone disease associated with antiepileptic drugs. Cleveland Clinical Journal of Medicine, 71, S42–S48. CrossRef
Poznanski, A. K. (1991). Useful measurements in the evaluation of hand radiographs. Hand Clinics, 7, 21–36. PubMed
Roche A. F., & Malina R. M., Eds. (1983). Manual of physical status and performance in childhood. Volume 1B: physical status (p. 1188). New York: Plenum Press.
Tanner, J. M., Healy, M. J. R., Goldstein, H., & Cameron, N. (2001). Assessment of skeletal maturity and prediction of adult height (TW3 method), 3rd ed. Philadelphia: W. B. Saunders.
Williams, P. G., Dalrymple, N., & Neal, J. (2000). Eating habits of children with autism. Pediatric Nursing, 26, 259–264. PubMed
- Reduced Bone Cortical Thickness in Boys with Autism or Autism Spectrum Disorder
Mary L. Hediger
Lucinda J. England
Cynthia A. Molloy
Kai F. Yu
James L. Mills
- Springer US