Skip to main content
Top
Gepubliceerd in:

17-08-2016

Recent viral infection in US blood donors and health-related quality of life (HRQOL)

Auteurs: Farnaz Vahidnia, Susan L. Stramer, Debra Kessler, Beth Shaz, German Leparc, David E. Krysztof, Simone A. Glynn, Brian Custer

Gepubliceerd in: Quality of Life Research | Uitgave 2/2017

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Purpose

Blood donors are considered to be one of the healthiest populations, but relatively little is known about their perceived quality of life. The objective was to examine HRQOL in donors infected with HIV, HBV, HCV or HTLV and a comparison group.

Methods

Donors with confirmed viral infection (cases) and donors who tested false-positive (controls) participated in a multicenter study of US blood donors (2010–2013), funded by the National Heart, Lung and Blood Institute (NHLBI). HRQOL was measured by the EuroQol Five Dimension (EQ-5D) instrument and EQ-5D visual analogue scale (VAS). The lower 25th ‰ of EQ-5D index or VAS score of controls was defined as a “lower HRQOL.”

Results

A total of 1574 controls completed the HRQOL assessment with a mean EQ-5D index of 0.94 (SD = 0.10) and EQ-VAS of 87.6 (SD = 10.6). Mean EQ-5D index for 192 HIV-, 315 HCV- and 195 HTLV-positive donors were significantly lower than the controls (0.86, 0.83 and 0.87; SD = 0.18, 0.20 and 0.16, respectively, p < 0.001). HBV-positive donors (n = 290) had a similar mean EQ-5D index (0.93, SD = 0.14, p = 0.05) to controls. Anxiety/depression was reported by 34 % of cases, compared with 13 % of controls. In multivariable modeling, the odds of lower HRQOL in HIV, HBV, HCV and HTLV cases were 2.1, 1.6, 2.6 and 2.3 times that of controls, respectively (p < 0.05).

Conclusions

HRQOL reported by blood donors with recent viral infections was relatively high but lower than controls. On average, HRQOL among HCV-positive donors was the lowest and HBV-positive donors reported scores similar to donors without infection.
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
Literatuur
2.
go back to reference Centers for Disease Control and Prevention (CDC). (1991). Public health service inter-agency guidelines for screening donors of blood, plasma, organs, tissues, and semen for evidence of hepatitis B and hepatitis C. MMWR, 40(RR-4), 1–17. Centers for Disease Control and Prevention (CDC). (1991). Public health service inter-agency guidelines for screening donors of blood, plasma, organs, tissues, and semen for evidence of hepatitis B and hepatitis C. MMWR, 40(RR-4), 1–17.
4.
go back to reference Brown, L. K., Whiteley, L., Harper, G. W., Nichols, S., Nieves, A., & Protocol Team for The Adolescent Medicine Trials Network for HIV/AIDS Interventions. (2015). Psychological symptoms among 2032 youth living with HIV: A multisite study. AIDS Patient Care STDS, 29(4), 212–219.CrossRefPubMedPubMedCentral Brown, L. K., Whiteley, L., Harper, G. W., Nichols, S., Nieves, A., & Protocol Team for The Adolescent Medicine Trials Network for HIV/AIDS Interventions. (2015). Psychological symptoms among 2032 youth living with HIV: A multisite study. AIDS Patient Care STDS, 29(4), 212–219.CrossRefPubMedPubMedCentral
5.
go back to reference Honiden, S., Sundaram, V., Nease, R. F., Holodniy, M., Lazzeroni, L. C., Zolopa, A., et al. (2006). The effect of diagnosis with HIV infection on health-related quality of life. Quality of Life Research, 15(1), 69–82.CrossRefPubMed Honiden, S., Sundaram, V., Nease, R. F., Holodniy, M., Lazzeroni, L. C., Zolopa, A., et al. (2006). The effect of diagnosis with HIV infection on health-related quality of life. Quality of Life Research, 15(1), 69–82.CrossRefPubMed
6.
go back to reference Rodger, A. J., Jolley, D., Thompson, S. C., Lanigan, A., & Crofts, N. (1999). The impact of diagnosis of hepatitis C virus on quality of life. Hepatology, 30(5), 1299–1301.CrossRefPubMed Rodger, A. J., Jolley, D., Thompson, S. C., Lanigan, A., & Crofts, N. (1999). The impact of diagnosis of hepatitis C virus on quality of life. Hepatology, 30(5), 1299–1301.CrossRefPubMed
7.
go back to reference Stasi, C., Silvestri, C., Voller, F., & Cipriani, F. (2015). The epidemiological changes of HCV and HBV infections in the era of new antiviral therapies and the anti-HBV vaccine. Journal of Infection and Public Health, 9(4), 389–395.CrossRefPubMed Stasi, C., Silvestri, C., Voller, F., & Cipriani, F. (2015). The epidemiological changes of HCV and HBV infections in the era of new antiviral therapies and the anti-HBV vaccine. Journal of Infection and Public Health, 9(4), 389–395.CrossRefPubMed
8.
go back to reference Atsma, F., Veldhuizen, I., Verbeek, A., de Kort, W., & de Vegt, F. (2011). Healthy donor effect: Its magnitude in health research among blood donors. Transfusion, 51(8), 1820–1828.CrossRefPubMed Atsma, F., Veldhuizen, I., Verbeek, A., de Kort, W., & de Vegt, F. (2011). Healthy donor effect: Its magnitude in health research among blood donors. Transfusion, 51(8), 1820–1828.CrossRefPubMed
9.
go back to reference Edgren, G., Tran, T. N., Hjalgrim, H., Rostgaard, K., Shanwell, A., Titlestad, K., et al. (2007). Improving health profile of blood donors as a consequence of transfusion safety efforts. Transfusion, 47(11), 2017–2024.CrossRefPubMed Edgren, G., Tran, T. N., Hjalgrim, H., Rostgaard, K., Shanwell, A., Titlestad, K., et al. (2007). Improving health profile of blood donors as a consequence of transfusion safety efforts. Transfusion, 47(11), 2017–2024.CrossRefPubMed
10.
go back to reference Shehu, E., Hofmann, A., Clement, M., & Langmaack, A. C. (2015). Healthy donor effect and satisfaction with health: The role of selection effects related to blood donation behavior. The European Journal of Health Economics, 16(7), 733–745.CrossRefPubMed Shehu, E., Hofmann, A., Clement, M., & Langmaack, A. C. (2015). Healthy donor effect and satisfaction with health: The role of selection effects related to blood donation behavior. The European Journal of Health Economics, 16(7), 733–745.CrossRefPubMed
11.
go back to reference Ullum, H., Rostgaard, K., Kamper-Jorgensen, M., Reilly, M., Melbye, M., Nyren, O., et al. (2015). Blood donation and blood donor mortality after adjustment for a healthy donor effect. Transfusion, 55(10), 2479–2485.CrossRefPubMed Ullum, H., Rostgaard, K., Kamper-Jorgensen, M., Reilly, M., Melbye, M., Nyren, O., et al. (2015). Blood donation and blood donor mortality after adjustment for a healthy donor effect. Transfusion, 55(10), 2479–2485.CrossRefPubMed
12.
go back to reference Guiltinan, A. M., Murphy, E. L., Horton, J. A., Nass, C. C., McEntire, R. L., & Watanabe, K. (1998). Psychological distress in blood donors notified of HTLV-I/II infection. Retrovirus epidemiology donor study. Transfusion, 38(11–12), 1056–1062.PubMed Guiltinan, A. M., Murphy, E. L., Horton, J. A., Nass, C. C., McEntire, R. L., & Watanabe, K. (1998). Psychological distress in blood donors notified of HTLV-I/II infection. Retrovirus epidemiology donor study. Transfusion, 38(11–12), 1056–1062.PubMed
13.
go back to reference Kanwal, F., Gralnek, I. M., Martin, P., Dulai, G. S., Farid, M., & Spiegel, B. M. (2005). Treatment alternatives for chronic hepatitis B virus infection: A cost-effectiveness analysis. Annals of Internal Medicine, 142(10), 821–831.CrossRefPubMed Kanwal, F., Gralnek, I. M., Martin, P., Dulai, G. S., Farid, M., & Spiegel, B. M. (2005). Treatment alternatives for chronic hepatitis B virus infection: A cost-effectiveness analysis. Annals of Internal Medicine, 142(10), 821–831.CrossRefPubMed
14.
go back to reference Ong, S. C., Mak, B., Aung, M. O., Li, S. C., & Lim, S. G. (2008). Health-related quality of life in chronic hepatitis B patients. Hepatology, 47(4), 1108–1117.CrossRefPubMed Ong, S. C., Mak, B., Aung, M. O., Li, S. C., & Lim, S. G. (2008). Health-related quality of life in chronic hepatitis B patients. Hepatology, 47(4), 1108–1117.CrossRefPubMed
15.
go back to reference Woo, G., Tomlinson, G., Yim, C., Lilly, L., Therapondos, G., Wong, D. K., et al. (2012). Health state utilities and quality of life in patients with hepatitis B. Canadian Journal of Gastroenterology and Hepatology, 26(7), 445–451. Woo, G., Tomlinson, G., Yim, C., Lilly, L., Therapondos, G., Wong, D. K., et al. (2012). Health state utilities and quality of life in patients with hepatitis B. Canadian Journal of Gastroenterology and Hepatology, 26(7), 445–451.
16.
go back to reference El Khoury, A. C., Vietri, J., & Prajapati, G. (2012). The burden of untreated hepatitis C virus infection: A US patients’ perspective. Digestive Diseases and Sciences, 57(11), 2995–3003.CrossRefPubMed El Khoury, A. C., Vietri, J., & Prajapati, G. (2012). The burden of untreated hepatitis C virus infection: A US patients’ perspective. Digestive Diseases and Sciences, 57(11), 2995–3003.CrossRefPubMed
17.
go back to reference Spiegel, B. M., Younossi, Z. M., Hays, R. D., Revicki, D., Robbins, S., & Kanwal, F. (2005). Impact of hepatitis C on health related quality of life: A systematic review and quantitative assessment. Hepatology, 41(4), 790–800.CrossRefPubMed Spiegel, B. M., Younossi, Z. M., Hays, R. D., Revicki, D., Robbins, S., & Kanwal, F. (2005). Impact of hepatitis C on health related quality of life: A systematic review and quantitative assessment. Hepatology, 41(4), 790–800.CrossRefPubMed
18.
go back to reference Whiteley, D., Elliott, L., Cunningham-Burley, S., & Whittaker, A. (2015). Health-related quality of life for individuals with hepatitis C: A narrative review. International Journal of Drug Policy, 26(10), 936–949.CrossRefPubMed Whiteley, D., Elliott, L., Cunningham-Burley, S., & Whittaker, A. (2015). Health-related quality of life for individuals with hepatitis C: A narrative review. International Journal of Drug Policy, 26(10), 936–949.CrossRefPubMed
19.
go back to reference Carvalho, A. G., Galvao-Phileto, A. V., Lima, N. S., Jesus, R. S., Galvao-Castro, B., & Lima, M. G. (2009). Frequency of mental disturbances in HTLV-1 patients in the state of Bahia, Brazil. Brazilian Journal of Infectious Diseases, 13(1), 5–8.CrossRefPubMed Carvalho, A. G., Galvao-Phileto, A. V., Lima, N. S., Jesus, R. S., Galvao-Castro, B., & Lima, M. G. (2009). Frequency of mental disturbances in HTLV-1 patients in the state of Bahia, Brazil. Brazilian Journal of Infectious Diseases, 13(1), 5–8.CrossRefPubMed
20.
go back to reference Guiltinan, A. M., Kaidarova, Z., Behan, D., Marosi, C., Hutching, S., Kaiser, M., et al. (2013). Major depression and generalized anxiety disorder among human T-lymphotropic virus types I- and II-infected former blood donors. Transfusion, 53(1), 60–68.CrossRefPubMed Guiltinan, A. M., Kaidarova, Z., Behan, D., Marosi, C., Hutching, S., Kaiser, M., et al. (2013). Major depression and generalized anxiety disorder among human T-lymphotropic virus types I- and II-infected former blood donors. Transfusion, 53(1), 60–68.CrossRefPubMed
21.
go back to reference Gillis, J., Cooper, C., Rourke, S., Rueda, S., O’Brien, K., Collins, E., et al. (2013). Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals. Quality of Life Research, 22(7), 1525–1535.CrossRefPubMed Gillis, J., Cooper, C., Rourke, S., Rueda, S., O’Brien, K., Collins, E., et al. (2013). Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals. Quality of Life Research, 22(7), 1525–1535.CrossRefPubMed
22.
go back to reference Kanwal, F., Gralnek, I. M., Hays, R. D., Dulai, G. S., Spiegel, B. M., Bozzette, S., et al. (2005). Impact of chronic viral hepatitis on health-related quality of life in HIV: Results from a nationally representative sample. American Journal of Gastroenterology, 100(9), 1984–1994.CrossRefPubMed Kanwal, F., Gralnek, I. M., Hays, R. D., Dulai, G. S., Spiegel, B. M., Bozzette, S., et al. (2005). Impact of chronic viral hepatitis on health-related quality of life in HIV: Results from a nationally representative sample. American Journal of Gastroenterology, 100(9), 1984–1994.CrossRefPubMed
23.
go back to reference Rabin, R., & de Charro, F. (2001). EQ-5D: A measure of health status from the EuroQol Group. Annals of Medicine, 33(5), 337–343.CrossRefPubMed Rabin, R., & de Charro, F. (2001). EQ-5D: A measure of health status from the EuroQol Group. Annals of Medicine, 33(5), 337–343.CrossRefPubMed
24.
go back to reference Janssen, M. F., Pickard, A. S., Golicki, D., Gudex, C., Niewada, M., Scalone, L., et al. (2013). Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L across eight patient groups: A multi-country study. Quality of Life Research, 22(7), 1717–1727.CrossRefPubMed Janssen, M. F., Pickard, A. S., Golicki, D., Gudex, C., Niewada, M., Scalone, L., et al. (2013). Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L across eight patient groups: A multi-country study. Quality of Life Research, 22(7), 1717–1727.CrossRefPubMed
25.
go back to reference Johnson, J. A., & Pickard, A. S. (2000). Comparison of the EQ-5D and SF-12 health surveys in a general population survey in Alberta, Canada. Medical Care, 38(1), 115–121.CrossRefPubMed Johnson, J. A., & Pickard, A. S. (2000). Comparison of the EQ-5D and SF-12 health surveys in a general population survey in Alberta, Canada. Medical Care, 38(1), 115–121.CrossRefPubMed
27.
go back to reference Custer, B., Kessler, D., Vahidnia, F., Leparc, G., Krysztof, D. E., Shaz, B., et al. (2015). Risk factors for retrovirus and hepatitis virus infections in accepted blood donors. Transfusion, 55(5), 1098–1107.CrossRefPubMed Custer, B., Kessler, D., Vahidnia, F., Leparc, G., Krysztof, D. E., Shaz, B., et al. (2015). Risk factors for retrovirus and hepatitis virus infections in accepted blood donors. Transfusion, 55(5), 1098–1107.CrossRefPubMed
28.
go back to reference Sharma, U. K., Stramer, S. L., Wright, D. J., Glynn, S. A., Hermansen, S., Schreiber, G. B., et al. (2003). Impact of changes in viral marker screening assays. Transfusion, 43(2), 202–214.CrossRefPubMed Sharma, U. K., Stramer, S. L., Wright, D. J., Glynn, S. A., Hermansen, S., Schreiber, G. B., et al. (2003). Impact of changes in viral marker screening assays. Transfusion, 43(2), 202–214.CrossRefPubMed
29.
go back to reference Custer, B., Kamel, H., Kiely, N. E., Murphy, E. L., & Busch, M. P. (2009). Associations between West Nile virus infection and symptoms reported by blood donors identified through nucleic acid test screening. Transfusion, 49(2), 278–288.CrossRefPubMed Custer, B., Kamel, H., Kiely, N. E., Murphy, E. L., & Busch, M. P. (2009). Associations between West Nile virus infection and symptoms reported by blood donors identified through nucleic acid test screening. Transfusion, 49(2), 278–288.CrossRefPubMed
30.
go back to reference The EuroQol Group. (1990). EuroQol—a new facility for the measurement of health-related quality of life. Health Policy, 16(3), 199–208.CrossRef The EuroQol Group. (1990). EuroQol—a new facility for the measurement of health-related quality of life. Health Policy, 16(3), 199–208.CrossRef
31.
go back to reference Oemar, M., & Oppe, M. (2013). EQ-5D-3L user guide, basic information on how to use the EQ-5D-3L instrument (5.0th ed.). The Netherlands: EuroQoL Group. Oemar, M., & Oppe, M. (2013). EQ-5D-3L user guide, basic information on how to use the EQ-5D-3L instrument (5.0th ed.). The Netherlands: EuroQoL Group.
32.
go back to reference Shaw, J. W., Johnson, J. A., & Coons, S. J. (2005). US valuation of the EQ-5D health states: Development and testing of the D1 valuation model. Medical Care, 43(3), 203–220.CrossRefPubMed Shaw, J. W., Johnson, J. A., & Coons, S. J. (2005). US valuation of the EQ-5D health states: Development and testing of the D1 valuation model. Medical Care, 43(3), 203–220.CrossRefPubMed
33.
go back to reference Revicki, D. A. (1992). Relationship between health utility and psychometric health status measures. Medical Care, 30(5 Suppl), MS274–MS282.PubMed Revicki, D. A. (1992). Relationship between health utility and psychometric health status measures. Medical Care, 30(5 Suppl), MS274–MS282.PubMed
34.
go back to reference Ferreira, F. A., de Almeida-Neto, C., Teixeira, M. C., & Strauss, E. (2015). Health-related quality of life among blood donors with hepatitis B and hepatitis C: Longitudinal study before and after diagnosis. Revista Brasileira de Hematologia e Hemoterapia, 37(6), 381–387.CrossRefPubMedPubMedCentral Ferreira, F. A., de Almeida-Neto, C., Teixeira, M. C., & Strauss, E. (2015). Health-related quality of life among blood donors with hepatitis B and hepatitis C: Longitudinal study before and after diagnosis. Revista Brasileira de Hematologia e Hemoterapia, 37(6), 381–387.CrossRefPubMedPubMedCentral
35.
go back to reference McAuley, J. D., Caglioti, S., Williams, R. C., Robertson, G. F., Morgan, L., Tobler, L. H., et al. (2004). Clinical significance of nondiscriminated reactive results with the Chiron Procleix HIV-1 and HCV assay. Transfusion, 44(1), 91–96.CrossRefPubMed McAuley, J. D., Caglioti, S., Williams, R. C., Robertson, G. F., Morgan, L., Tobler, L. H., et al. (2004). Clinical significance of nondiscriminated reactive results with the Chiron Procleix HIV-1 and HCV assay. Transfusion, 44(1), 91–96.CrossRefPubMed
36.
go back to reference Vahidnia, F., Stramer, S. L., Kessler, D., Goncalez, T. T., Shaz, B. H., Leparc, G., et al. (2016). Motivations for donating and attitudes toward screening policies in US blood donors with viral infection. Transfusion, 56(8), 2013–2020.CrossRefPubMed Vahidnia, F., Stramer, S. L., Kessler, D., Goncalez, T. T., Shaz, B. H., Leparc, G., et al. (2016). Motivations for donating and attitudes toward screening policies in US blood donors with viral infection. Transfusion, 56(8), 2013–2020.CrossRefPubMed
37.
go back to reference Tillmann, H. L., Wiese, M., Braun, Y., Wiegand, J., Tenckhoff, S., Mossner, J., et al. (2011). Quality of life in patients with various liver diseases: Patients with HCV show greater mental impairment, while patients with PBC have greater physical impairment. Journal of Viral Hepatitis, 18(4), 252–261.CrossRefPubMed Tillmann, H. L., Wiese, M., Braun, Y., Wiegand, J., Tenckhoff, S., Mossner, J., et al. (2011). Quality of life in patients with various liver diseases: Patients with HCV show greater mental impairment, while patients with PBC have greater physical impairment. Journal of Viral Hepatitis, 18(4), 252–261.CrossRefPubMed
38.
go back to reference Helbling, B., Overbeck, K., Gonvers, J. J., Malinverni, R., Dufour, J. F., Borovicka, J., et al. (2008). Host-rather than virus-related factors reduce health-related quality of life in hepatitis C virus infection. Gut, 57(11), 1597–1603.CrossRefPubMed Helbling, B., Overbeck, K., Gonvers, J. J., Malinverni, R., Dufour, J. F., Borovicka, J., et al. (2008). Host-rather than virus-related factors reduce health-related quality of life in hepatitis C virus infection. Gut, 57(11), 1597–1603.CrossRefPubMed
39.
go back to reference Rowan, P. J., Al-Jurdi, R., Tavakoli-Tabasi, S., Kunik, M. E., Satrom, S. L., & El-Serag, H. B. (2005). Physical and psychosocial contributors to quality of life in veterans with hepatitis C not on antiviral therapy. Journal of Clinical Gastroenterology, 39(8), 731–736.CrossRefPubMed Rowan, P. J., Al-Jurdi, R., Tavakoli-Tabasi, S., Kunik, M. E., Satrom, S. L., & El-Serag, H. B. (2005). Physical and psychosocial contributors to quality of life in veterans with hepatitis C not on antiviral therapy. Journal of Clinical Gastroenterology, 39(8), 731–736.CrossRefPubMed
40.
go back to reference Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., et al. (2012). Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010. Lancet, 380(9859), 2095–2128.CrossRefPubMed Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., et al. (2012). Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010. Lancet, 380(9859), 2095–2128.CrossRefPubMed
43.
go back to reference Brazier, J., Jones, N., & Kind, P. (1993). Testing the validity of the Euroqol and comparing it with the SF-36 health survey questionnaire. Quality of Life Research, 2(3), 169–180.CrossRefPubMed Brazier, J., Jones, N., & Kind, P. (1993). Testing the validity of the Euroqol and comparing it with the SF-36 health survey questionnaire. Quality of Life Research, 2(3), 169–180.CrossRefPubMed
Metagegevens
Titel
Recent viral infection in US blood donors and health-related quality of life (HRQOL)
Auteurs
Farnaz Vahidnia
Susan L. Stramer
Debra Kessler
Beth Shaz
German Leparc
David E. Krysztof
Simone A. Glynn
Brian Custer
Publicatiedatum
17-08-2016
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 2/2017
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1392-5

Andere artikelen Uitgave 2/2017

Quality of Life Research 2/2017 Naar de uitgave