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01-02-2015 | Original Article | Uitgave 2/2015 Open Access

Netherlands Heart Journal 2/2015

Rationale and design of the Measuring Athlete’s Risk of Cardiovascular events (MARC) study

The role of coronary CT in the cardiovascular evaluation of middle-aged sportsmen

Tijdschrift:
Netherlands Heart Journal > Uitgave 2/2015
Auteurs:
T. L. Braber, A. Mosterd, N. H. J. Prakken, P. A. F. M. Doevendans, W. P. Th. M. Mali, F. J. G. Backx, D. E. Grobbee, R. Rienks, H. M. Nathoe, M. L. Bots, B. K. Velthuis
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Electronic supplementary material

The online version of this article (doi:10.​1007/​s12471-014-0630-0) contains supplementary material, which is available to authorized users.

Abstract

Background

More than 90 % of exercise-related cardiac arrests occur in men, predominantly those aged 45 years and older with coronary artery disease (CAD) as the main cause. The current sports medical evaluation (SME) of middle-aged recreational athletes consists of a medical history, physical examination, and resting and exercise electrocardiography. Coronary CT (CCT) provides a minimally invasive low radiation dose opportunity to image the coronary arteries. We present the study protocol of the Measuring Athlete’s Risk of Cardiovascular events (MARC) study. MARC aims to assess the additional value of CCT to a routine SME in asymptomatic sportsmen ≥45 years without known CAD.

Design

MARC is a prospective study of 300 asymptomatic sportsmen ≥45 years who will undergo CCT if the SME does not reveal any cardiac abnormalities. The prevalence and determinants of CAD (coronary artery calcium score ≥100 Agatston Units (AU) or ≥50 % luminal stenosis) will be reported. The number needed to screen to prevent the occurrence of one cardiovascular event in the next 5 years, conditional to adequate treatment, will be estimated.

Discussion

We aim to determine the prevalence and severity of CAD and the additional value of CCT in asymptomatic middle-aged (≥45 years) sportsmen whose routine SME revealed no cardiac abnormalities.

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Netherlands Heart Journal

Het Netherlands Heart Journal wordt uitgegeven in samenwerking met de Nederlandse Vereniging voor Cardiologie en de Nederlandse Hartstichting. Het tijdschrift is Engelstalig en wordt gratis beschikbaa ...

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