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Gepubliceerd in: Journal of Autism and Developmental Disorders 6/2018

30-01-2018 | Original Paper

Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia

Auteurs: Enrico Danzer, Casey Hoffman, Jo Ann D’Agostino, Judith S. Miller, Lindsay N. Waqar, Marsha Gerdes, Judy C. Bernbaum, Hannah Rosenthal, Natalie E. Rintoul, Lisa M. Herkert, William H. Peranteau, Alan W. Flake, N. Scott Adzick, Holly L. Hedrick

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2018

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Abstract

To determine the rate and predictors of autism spectrum disorder (ASD) in congenital diaphragmatic hernia (CDH). Between 06/2004 and 09/2015 a total of 110 CDH survivors underwent neurodevelopmental (ND) testing and screening for ASD, followed by a full autism diagnostic evaluation if indicated at our institution. We found a 9 time higher rate of ASD in CDH children compared to the general population (P = 0.0002). Multiple patient-related and clinical variables risk factors of ASD were identified by univariate analysis. However, only short-term and long-term neurodevelopmental delays were strongly associated with ASD in CDH by multivariate comparisons. There is a striking prevalence of ASD in CDH survivors and our findings suggest that all CDH children should be regularly screened for ASD.
Literatuur
go back to reference Christensen, D.L., et al. (2016). Prevalence and characteristics of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2012. Morbidity and Mortality Weekly Report: Surveillance Summaries, 65, 1–23. https://doi.org/10.15585/mmwr.ss6503a1. Christensen, D.L., et al. (2016). Prevalence and characteristics of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2012. Morbidity and Mortality Weekly Report: Surveillance Summaries, 65, 1–23. https://​doi.​org/​10.​15585/​mmwr.​ss6503a1.
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Metagegevens
Titel
Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia
Auteurs
Enrico Danzer
Casey Hoffman
Jo Ann D’Agostino
Judith S. Miller
Lindsay N. Waqar
Marsha Gerdes
Judy C. Bernbaum
Hannah Rosenthal
Natalie E. Rintoul
Lisa M. Herkert
William H. Peranteau
Alan W. Flake
N. Scott Adzick
Holly L. Hedrick
Publicatiedatum
30-01-2018
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 6/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-018-3472-6

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