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Gepubliceerd in: Journal of Autism and Developmental Disorders 7/2014

01-07-2014 | Original Paper

Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11

Auteurs: Judith S. Nijmeijer, Alejandro Arias-Vásquez, Nanda N. J. Rommelse, Marieke E. Altink, Cathelijne J. M. Buschgens, Ellen A. Fliers, Barbara Franke, Ruud B. Minderaa, Joseph A. Sergeant, Jan K. Buitelaar, Pieter J. Hoekstra, Catharina A. Hartman

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 7/2014

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Abstract

We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children’s Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing.
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Metagegevens
Titel
Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11
Auteurs
Judith S. Nijmeijer
Alejandro Arias-Vásquez
Nanda N. J. Rommelse
Marieke E. Altink
Cathelijne J. M. Buschgens
Ellen A. Fliers
Barbara Franke
Ruud B. Minderaa
Joseph A. Sergeant
Jan K. Buitelaar
Pieter J. Hoekstra
Catharina A. Hartman
Publicatiedatum
01-07-2014
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 7/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-014-2039-4