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Gepubliceerd in: Journal of Autism and Developmental Disorders 3/2007

01-03-2007 | Original Paper

Quantitative Assessment of Autism Symptom-related Traits in Probands and Parents: Broader Phenotype Autism Symptom Scale

Auteurs: Geraldine Dawson, Annette Estes, Jeffrey Munson, Gerard Schellenberg, Raphael Bernier, Robert Abbott

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2007

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Abstract

Autism susceptibility genes likely have effects on continuously distributed autism-related traits, yet few measures of such traits exist. The Broader Phenotype Autism Symptom Scale (BPASS), developed for use with affected children and family members, measures social motivation, social expressiveness, conversational skills, and flexibility. Based on 201 multiplex families, psychometric data on the BPASS are reported. Adequate inter-rater reliability and internal consistency were found. Parents had lower BPASS scores than affected children, after controlling for IQ. Parents and affected children showed overlapping distributions suggesting the BPASS captured variability in traits across groups. BPASS scores were not correlated with ethnicity or parent education; however, some domains were correlated with IQ. The BPASS holds promise as a quantitative phenotypic assessment for genetic studies.
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Metagegevens
Titel
Quantitative Assessment of Autism Symptom-related Traits in Probands and Parents: Broader Phenotype Autism Symptom Scale
Auteurs
Geraldine Dawson
Annette Estes
Jeffrey Munson
Gerard Schellenberg
Raphael Bernier
Robert Abbott
Publicatiedatum
01-03-2007
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2007
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-006-0182-2