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Journal of Autism and Developmental Disorders

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01-11-2009 | Original Paper

Quantitative Architectural Analysis: A New Approach to Cortical Mapping

Auteurs: Axel Schleicher, Patricia Morosan, Katrin Amunts, Karl Zilles

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2009

Abstract

Results from functional imaging studies are often still interpreted using the classical architectonic brain maps of Brodmann and his successors. One obvious weakness in traditional, architectural mapping is the subjective nature of localizing borders between cortical areas by means of a purely visual, microscopical examination of histological specimens. To overcome this limitation, objective mapping procedures based on quantitative cytoarchitecture have been generated. As a result, new maps for various species including man were established. In our contribution, principles of quantitative cytoarchitecture and algorithm-based cortical mapping are described for a cytoarchitectural parcellation of the human auditory cortex. Defining cortical borders based on quantified changes in cortical lamination is the decisive step towards a novel, highly improved probabilistic brain atlas.

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Titel: Quantitative Architectural Analysis: A New Approach to Cortical Mapping
Auteurs: Axel Schleicher
Patricia Morosan
Katrin Amunts
Karl Zilles
Publicatiedatum: 01-11-2009
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-009-0790-8

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