Top

Gepubliceerd in:

08-05-2018

Quality of life, problems, and needs of disease-free breast cancer survivors 5 years after diagnosis

Auteurs: Martina E. Schmidt, Joachim Wiskemann, Karen Steindorf

Gepubliceerd in: Quality of Life Research | Uitgave 8/2018

Abstract

Purpose

After cancer treatment, it is desirable to maintain or regain a high quality of life (QoL) and the ability to accomplish everyday tasks well. Therefore, we substantiated the scarce knowledge regarding long-term QoL after breast cancer, burdensome problems, and unmet needs for more support.

Methods

Disease-free breast cancer survivors (n = 190) who had participated in two randomized controlled exercise trials during primary treatment were followed up to 5 years post-diagnosis. QoL-related functions and symptoms (EORTC QLQ-C30/-BR23), health problems, and support needs were assessed. EORTC-QLQ scores were compared with age-matched normative values from the general population in Germany.

Results

QoL-related functions and symptoms in patients during cancer treatment were worse compared to healthy references, but largely improved over time. Yet, cognitive function and sleep were still significantly impaired at 5-year follow-up. Other common long-term problems included sexual issues (45% of survivors), hot flashes (38%), pain (34%), fatigue (24%), and polyneuropathy (21%). Regression analyses indicated fatigue having the strongest impact on global QoL. Support needs were expressed mainly for menopausal disorders (43%), physical performance (39%), sleep problems (38%), arthralgia (37%), cognitive problems (36%), weight problems (32%), and fatigue (31%).

Conclusions

While QoL in disease-free breast cancer survivors 5 years post-diagnosis was largely comparable to the general population on average, still many survivors suffered from adverse effects. There appears to be a need for ongoing screening and support regarding fatigue, sleep problems, cognitive problems, arthralgia/pain, menopausal/sexual symptoms, physical performance, and weight problems during and several years following breast cancer therapy.

vorige artikel Health-related quality of life of African-American female breast cancer survivors, survivors of other cancers, and those without cancer

volgende artikel Diabetic retinopathy and health-related quality of life among Chinese with known type 2 diabetes mellitus

American Cancer Society. (2016). Cancer treatment & survivorship facts & figuress. 2016-2017. Atlanta: American Cancer Society.

Aubin, M., Giguere, A., Martin, M., Verreault, R., Fitch, M. I., Kazanjian, A., et al. (2012). Interventions to improve continuity of care in the follow-up of patients with cancer. The Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD007672.PubMedCrossRef

Nyarko, E., Metz, J. M., Nguyen, G. T., Hampshire, M. K., Jacobs, L. A., & Mao, J. J. (2015). Cancer survivors’ perspectives on delivery of survivorship care by primary care physicians: An internet-based survey. BMC Family Practice, 16, 143. https://doi.org/10.1186/s12875-015-0367-x.CrossRefPubMedPubMedCentral

Mao, J. J., Bowman, M. A., Stricker, C. T., DeMichele, A., Jacobs, L., Chan, D., et al. (2009). Delivery of survivorship care by primary care physicians: The perspective of breast cancer patients. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 27(6), 933–938. https://doi.org/10.1200/JCO.2008.18.0679.CrossRef

Berger, A. M., Mitchell, S. A., Jacobsen, P. B., & Pirl, W. F. (2015). Screening, evaluation, and management of cancer-related fatigue: Ready for implementation to practice? CA: A Cancer Journal for Clinicians, 65(3), 190–211. https://doi.org/10.3322/caac.21268.CrossRef

Selamat, M. H., Loh, S. Y., Mackenzie, L., & Vardy, J. (2014). Chemobrain experienced by breast cancer survivors: A meta-ethnography study investigating research and care implications. PLoS One, 9(9), e108002. https://doi.org/10.1371/journal.pone.0108002.CrossRefPubMedPubMedCentral

Bijker, R., Duijts, S. F. A., Smith, S. N., de Wildt-Liesveld, R., Anema, J. R., & Regeer, B. J. (2017). Functional impairments and work-related outcomes in breast cancer survivors: A systematic review. Journal of Occupational Rehabilitation. https://doi.org/10.1007/s10926-017-9736-8.PubMedCrossRefPubMedCentral

Koch, L., Jansen, L., Herrmann, A., Stegmaier, C., Holleczek, B., Singer, S., et al. (2013). Quality of life in long-term breast cancer survivors—A 10-year longitudinal population-based study. Acta Oncologica, 52(6), 1119–1128. https://doi.org/10.3109/0284186X.2013.774461.CrossRefPubMed

Arndt, V., Koch-Gallenkamp, L., Jansen, L., Bertram, H., Eberle, A., Holleczek, B., et al. (2017). Quality of life in long-term and very long-term cancer survivors versus population controls in Germany. Acta Oncologica, 56(2), 190–197. https://doi.org/10.1080/0284186X.2016.1266089.CrossRefPubMed

10.

Hsu, T., Ennis, M., Hood, N., Graham, M., & Goodwin, P. J. (2013). Quality of life in long-term breast cancer survivors. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 31(28), 3540–3548. https://doi.org/10.1200/JCO.2012.48.1903.CrossRef

11.

Muzzatti, B., Flaiban, C., Surbone, A., & Annunziata, M. A. (2015) Quality of life profile in Italian long-term cancer survivors. Quality of life research: An international journal of quality of life aspects of treatment. Care and Rehabilitation, 24(4), 959–967. https://doi.org/10.1007/s11136-014-0831-4.CrossRef

12.

Minton, O., & Stone, P. (2008). How common is fatigue in disease-free breast cancer survivors? A systematic review of the literature. Breast Cancer Research and Treatment, 112(1), 5–13. https://doi.org/10.1007/s10549-007-9831-1.CrossRefPubMed

13.

Schmidt, M. E., Wiskemann, J., Armbrust, P., Schneeweiss, A., Ulrich, C. M., & Steindorf, K. (2015). Effects of resistance exercise on fatigue and quality of life in breast cancer patients undergoing adjuvant chemotherapy: A randomized controlled trial. International Journal of Cancer, 137(2), 471–480. https://doi.org/10.1002/ijc.29383.CrossRefPubMed

14.

Steindorf, K., Schmidt, M. E., Klassen, O., Ulrich, C. M., Oelmann, J., Habermann, N., et al. (2014). Randomized controlled trial of resistance training in breast cancer patients receiving adjuvant radiotherapy: Results on cancer-related fatigue and quality of life. Annals of Oncology: Official Journal of the European Society for Medical Oncology/ESMO. https://doi.org/10.1093/annonc/mdu374.CrossRef

15.

Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., et al. (1993). The European organization for research and treatment of cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85(5), 365–376.CrossRefPubMed

16.

Fayers, P. M., Aaronson, N. K., Bjordal, K., Curran, D., Groenvold, M., Curran, D., et al. (2001). EORTC Scoring Manual. 3rd edn. Brussels: European Organisation for Research and Treatment of Cancer. Report No.: 2-930064-16-1.

17.

Waldmann, A., Schubert, D., & Katalinic, A. (2013). Normative data of the EORTC QLQ-C30 for the German population: A population-based survey. PLoS ONE, 8(9), e74149. https://doi.org/10.1371/journal.pone.0074149.CrossRefPubMedPubMedCentral

18.

Fabrigar, L. R. W., Duane, T., MacCallum, R. C., & Strahan, E. J. (1999). Evaluating the use of exploratory factor analysis in psychological research. Psychological Methods, 4(3), 272–299.CrossRef

19.

Ousmen, A., Conroy, T., Guillemin, F., Velten, M., Jolly, D., Mercier, M., et al. (2016). Impact of the occurrence of a response shift on the determination of the minimal important difference in a health-related quality of life score over time. Health and Quality of Life Outcomes, 14(1), 167. https://doi.org/10.1186/s12955-016-0569-5.CrossRefPubMedPubMedCentral

20.

Joly, F., Giffard, B., Rigal, O., De Ruiter, M. B., Small, B. J., Dubois, M., et al. (2015). Impact of cancer and its treatments on cognitive function: Advances in research from the Paris International Cognition and Cancer Task Force Symposium and update since 2012. Journal of Pain and Symptom Management, 50(6), 830–841. https://doi.org/10.1016/j.jpainsymman.2015.06.019.CrossRefPubMed

21.

Wefel, J. S., Kesler, S. R., Noll, K. R., & Schagen, S. B. (2015). Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer-related cognitive impairment in adults. CA: A Cancer Journal for Clinicians, 65(2), 123–138. https://doi.org/10.3322/caac.21258.CrossRef

22.

Treanor, C. J., McMenamin, U. C., O’Neill, R. F., Cardwell, C. R., Clarke, M. J., Cantwell, M., et al. (2016). Non-pharmacological interventions for cognitive impairment due to systemic cancer treatment. The Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD011325.PubMedCrossRef

23.

Lowery-Allison, A. E., Passik, S. D., Cribbet, M. R., Reinsel, R. A., O’Sullivan, B., Norton, L., et al. (2017) Sleep problems in breast cancer survivors 1-10 years posttreatment. Palliative & Supportive Care. https://doi.org/10.1017/S1478951517000311.CrossRef

24.

Jim, H. S., Jacobsen, P. B., Phillips, K. M., Wenham, R. M., Roberts, W., & Small, B. J. (2013). Lagged relationships among sleep disturbance, fatigue, and depressed mood during chemotherapy. Health Psychology, 32(7), 768–774. https://doi.org/10.1037/a0031322.CrossRefPubMedPubMedCentral

25.

Fortier-Brochu, E., & Morin, C. M. (2014). Cognitive impairment in individuals with insomnia: Clinical significance and correlates. Sleep, 37(11), 1787–1798. https://doi.org/10.5665/sleep.4172.CrossRefPubMedPubMedCentral

26.

Lim, J., & Dinges, D. F. (2010). A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. Psychological Bulletin, 136(3), 375–389. https://doi.org/10.1037/a0018883.CrossRefPubMedPubMedCentral

27.

Henneghan, A., Stuifbergen, A., Becker, H., Kesler, S., & King, E. (2017). Modifiable correlates of perceived cognitive function in breast cancer survivors up to 10 years after chemotherapy completion. Journal of Cancer Survivorship: Research and Practice. https://doi.org/10.1007/s11764-017-0661-9.CrossRef

28.

Trudel-Fitzgerald, C., Zhou, E. S., Poole, E. M., Zhang, X., Michels, K. B., Eliassen, A. H., et al. (2017). Sleep and survival among women with breast cancer: 30 years of follow-up within the Nurses’ Health Study. British Journal of Cancer, 116(9), 1239–1246. https://doi.org/10.1038/bjc.2017.85.CrossRefPubMedPubMedCentral

29.

Steindorf, K., Wiskemann, J., Ulrich, C. M., & Schmidt, M. E. (2017). Effects of exercise on sleep problems in breast cancer patients receiving radiotherapy: A randomized clinical trial. Breast Cancer Research and Treatment, 162, 489–499. https://doi.org/10.1007/s10549-017-4141-8.CrossRefPubMed

30.

Courneya, K. S., Segal, R. J., Mackey, J. R., Gelmon, K., Friedenreich, C. M., Yasui, Y., et al. (2014). Effects of exercise dose and type on sleep quality in breast cancer patients receiving chemotherapy: A multicenter randomized trial. Breast Cancer Research and Treatment, 144(2), 361–369. https://doi.org/10.1007/s10549-014-2883-0.CrossRefPubMed

31.

Berger, A. M., & Mooney, K. (2016). Dissemination and implementation of guidelines for cancer-related fatigue. Journal of the National Comprehensive Cancer Network: JNCCN, 14(11), 1336–1338.CrossRefPubMed

32.

Berger, A. M., Mooney, K., Alvarez-Perez, A., Breitbart, W. S., Carpenter, K. M., Cella, D., et al. (2015). Cancer-related fatigue, version 2.2015. Journal of the National Comprehensive Cancer Network: JNCCN, 13(8), 1012–1039.CrossRefPubMed

33.

Ho, S. Y., Rohan, K. J., Parent, J., Tager, F. A., & McKinley, P. S. (2015). A longitudinal study of depression, fatigue, and sleep disturbances as a symptom cluster in women with breast cancer. Journal of Pain and Symptom Management, 49(4), 707–715. https://doi.org/10.1016/j.jpainsymman.2014.09.009.CrossRefPubMed

34.

Donovan, K. A., & Jacobsen, P. B. (2007). Fatigue, depression, and insomnia: Evidence for a symptom cluster in cancer. Seminars in Oncology Nursing, 23(2), 127–135. https://doi.org/10.1016/j.soncn.2007.01.004.CrossRefPubMed

35.

Barsevick, A. M. (2007). The elusive concept of the symptom cluster. Oncology Nursing Forum, 34(5), 971–980. https://doi.org/10.1188/07.ONF.971-980.CrossRefPubMed

36.

Gupta, P., Sturdee, D. W., Palin, S. L., Majumder, K., Fear, R., Marshall, T., et al. (2006). Menopausal symptoms in women treated for breast cancer: The prevalence and severity of symptoms and their perceived effects on quality of life. Climacteric, 9(1), 49–58. https://doi.org/10.1080/13697130500487224.CrossRefPubMed

37.

Davis, S. R., Panjari, M., Robinson, P. J., Fradkin, P., & Bell, R. J. (2014). Menopausal symptoms in breast cancer survivors nearly 6 years after diagnosis. Menopause, 21(10), 1075–1081. https://doi.org/10.1097/GME.0000000000000219.CrossRefPubMed

38.

Hill, E. K., Sandbo, S., Abramsohn, E., Makelarski, J., Wroblewski, K., Wenrich, E. R., et al. (2011). Assessing gynecologic and breast cancer survivors’ sexual health care needs. Cancer, 117(12), 2643–2651. https://doi.org/10.1002/cncr.25832.CrossRefPubMed

39.

Stabile, C., Goldfarb, S., Baser, R. E., Goldfrank, D. J., Abu-Rustum, N. R., Barakat, R. R., et al. (2017). Sexual health needs and educational intervention preferences for women with cancer. Breast Cancer Research and Treatment, 165(1), 77–84. https://doi.org/10.1007/s10549-017-4305-6.CrossRefPubMedPubMedCentral

40.

Santen, R. J., Stuenkel, C. A., Davis, S. R., Pinkerton, J. V., Gompel, A., & Lumsden, M. A. (2017). Managing menopausal symptoms and associated clinical issues in breast cancer survivors. The Journal of Clinical Endocrinology and Metabolism, 102(10), 3647–3661. https://doi.org/10.1210/jc.2017-01138.CrossRefPubMed

41.

Klassen, O., Schmidt, M. E., Scharhag-Rosenberger, F., Sorkin, M., Ulrich, C. M., Schneeweiss, A., et al. (2014). Cardiorespiratory fitness in breast cancer patients undergoing adjuvant therapy. Acta Oncologica, 53(10), 1356–1365. https://doi.org/10.3109/0284186X.2014.899435.CrossRefPubMed

42.

Klassen, O., Schmidt, M. E., Ulrich, C. M., Schneeweiss, A., Potthoff, K., Steindorf, K., et al. (2017). Muscle strength in breast cancer patients receiving different treatment regimes. Journal of Cachexia, Sarcopenia and Muscle, 8(2), 305–316. https://doi.org/10.1002/jcsm.12165.CrossRefPubMed

43.

Lakoski, S. G., Barlow, C. E., Koelwyn, G. J., Hornsby, W. E., Hernandez, J., Defina, L. F., et al. (2013). The influence of adjuvant therapy on cardiorespiratory fitness in early-stage breast cancer seven years after diagnosis: The Cooper Center Longitudinal Study. Breast Cancer Research and Treatment, 138(3), 909–916.CrossRefPubMedPubMedCentral

44.

Beckwee, D., Leysen, L., Meuwis, K., & Adriaenssens, N. (2017). Prevalence of aromatase inhibitor-induced arthralgia in breast cancer: A systematic review and meta-analysis. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 25(5), 1673–1686. https://doi.org/10.1007/s00520-017-3613-z.CrossRef

45.

Hershman, D. L., Shao, T., Kushi, L. H., Buono, D., Tsai, W. Y., Fehrenbacher, L., et al. (2011). Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer. Breast Cancer Research and Treatment, 126(2), 529–537. https://doi.org/10.1007/s10549-010-1132-4.CrossRefPubMed

46.

Yang, G. S., Kim, H. J., Griffith, K. A., Zhu, S., Dorsey, S. G., & Renn, C. L. (2017). Interventions for the treatment of aromatase inhibitor-associated arthralgia in breast cancer survivors: A systematic review and meta-analysis. Cancer Nursing, 40(4), E26–E41. https://doi.org/10.1097/NCC.0000000000000409.CrossRef

47.

Irwin, M. L., Cartmel, B., Gross, C. P., Ercolano, E., Li, F., Yao, X., et al. (2015). Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 33(10), 1104–1111. https://doi.org/10.1200/JCO.2014.57.1547.CrossRef

48.

Brewer, J. R., Morrison, G., Dolan, M. E., & Fleming, G. F. (2016). Chemotherapy-induced peripheral neuropathy: Current status and progress. Gynecologic Oncology, 140(1), 176–183. https://doi.org/10.1016/j.ygyno.2015.11.011.CrossRefPubMed

49.

Jiralerspong, S., & Goodwin, P. J. (2016). Obesity and breast cancer prognosis: Evidence, challenges, and opportunities. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 34(35), 4203–4216. https://doi.org/10.1200/JCO.2016.68.4480.CrossRef

50.

Steindorf, K., Schmidt, M. E., Klassen, O., Oelmann, J., Hof, H., Debus, J., et al. (2014). Progressive resistance training in breast cancer patients undergoing adjuvant radiotherapy: Results of a randomized trial. Medicine and Science in Sports and Exercise, 46(5S), 368–369.CrossRef

51.

Schmidt, M. E., Wiskemann, J., Ulrich, C. M., Schneeweiss, A., & Steindorf, K. (2017). Self-reported physical activity behavior of breast cancer survivors during and after adjuvant therapy: 12 months follow-up of two randomized exercise intervention trials. Acta Oncologica, 56(4), 618–627. https://doi.org/10.1080/0284186X.2016.1275776.CrossRefPubMed

52.

Schmidt, M. E., Wiskemann, J., Schneeweiss, A., Potthoff, K., Ulrich, C. M., & Steindorf, K. (2017). Determinants of physical, affective, and cognitive fatigue during breast cancer therapy and 12 months follow-up. International Journal of Cancer. https://doi.org/10.1002/ijc.31138.CrossRefPubMedPubMedCentral

Titel: Quality of life, problems, and needs of disease-free breast cancer survivors 5 years after diagnosis
Auteurs: Martina E. Schmidt
Joachim Wiskemann
Karen Steindorf
Publicatiedatum: 08-05-2018
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 8/2018
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-018-1866-8

Andere artikelen Uitgave 8/2018

Maternal quality of life in routine labor epidural analgesia versus labor analgesia on request: results of a randomized trial

Open Access

Measuring quality of life in patients with stress urinary incontinence: is the ICIQ-UI-SF adequate?

Long-term quality of life improvement for chronic intractable back and leg pain patients using spinal cord stimulation: 12-month results from the SENZA-RCT

Open Access

Systematic review of quality of life in Turner syndrome

Review

Bohn Stafleu van Loghum

Quality of life, problems, and needs of disease-free breast cancer survivors 5 years after diagnosis

Abstract

Purpose

Methods

Results

Conclusions

Andere artikelen Uitgave 8/2018

Maternal quality of life in routine labor epidural analgesia versus labor analgesia on request: results of a randomized trial

Measuring quality of life in patients with stress urinary incontinence: is the ICIQ-UI-SF adequate?

Long-term quality of life improvement for chronic intractable back and leg pain patients using spinal cord stimulation: 12-month results from the SENZA-RCT

Systematic review of quality of life in Turner syndrome

Health-related quality of life of African-American female breast cancer survivors, survivors of other cancers, and those without cancer

Executive function and quality of life in individuals with Marfan syndrome

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Purpose

Methods

Results

Conclusions

Log in om toegang te krijgen

Maternal quality of life in routine labor epidural analgesia versus labor analgesia on request: results of a randomized trial

Measuring quality of life in patients with stress urinary incontinence: is the ICIQ-UI-SF adequate?

Long-term quality of life improvement for chronic intractable back and leg pain patients using spinal cord stimulation: 12-month results from the SENZA-RCT

Systematic review of quality of life in Turner syndrome

Health-related quality of life of African-American female breast cancer survivors, survivors of other cancers, and those without cancer

Executive function and quality of life in individuals with Marfan syndrome